examples of research topics in biology

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Published by Robert Bruce at August 29th, 2023 , Revised On September 5, 2023

Biology Research Topics

Are you in need of captivating and achievable research topics within the field of biology? Your quest for the best biology topics ends right here as this article furnishes you with 100 distinctive and original concepts for biology research, laying the groundwork for your research endeavor.

Table of Contents

Our proficient researchers have thoughtfully curated these biology research themes, considering the substantial body of literature accessible and the prevailing gaps in research.

Should none of these topics elicit enthusiasm, our specialists are equally capable of proposing tailor-made research ideas in biology, finely tuned to cater to your requirements. 

Thus, without further delay, we present our compilation of biology research topics crafted to accommodate students and researchers.

Research Topics in Marine Biology

• Impact of climate change on coral reef ecosystems.
• Biodiversity and adaptation of deep-sea organisms.
• Effects of pollution on marine life and ecosystems.
• Role of marine protected areas in conserving biodiversity.
• Microplastics in marine environments: sources, impacts, and mitigation.

Biological Anthropology Research Topics

• Evolutionary implications of early human migration patterns.
• Genetic and environmental factors influencing human height variation.
• Cultural evolution and its impact on human societies.
• Paleoanthropological insights into human dietary adaptations.
• Genetic diversity and population history of indigenous communities.

Biological Psychology Research Topics 

• Neurobiological basis of addiction and its treatment.
• Impact of stress on brain structure and function.
• Genetic and environmental influences on mental health disorders.
• Neural mechanisms underlying emotions and emotional regulation.
• Role of the gut-brain axis in psychological well-being.

Cancer Biology Research Topics 

• Targeted therapies in precision cancer medicine.
• Tumor microenvironment and its influence on cancer progression.
• Epigenetic modifications in cancer development and therapy.
• Immune checkpoint inhibitors and their role in cancer immunotherapy.
• Early detection and diagnosis strategies for various types of cancer.

Also read: Cancer research topics

Cell Biology Research Topics

• Mechanisms of autophagy and its implications in health and disease.
• Intracellular transport and organelle dynamics in cell function.
• Role of cell signaling pathways in cellular response to external stimuli.
• Cell cycle regulation and its relevance to cancer development.
• Cellular mechanisms of apoptosis and programmed cell death.

Developmental Biology Research Topics 

• Genetic and molecular basis of limb development in vertebrates.
• Evolution of embryonic development and its impact on morphological diversity.
• Stem cell therapy and regenerative medicine approaches.
• Mechanisms of organogenesis and tissue regeneration in animals.
• Role of non-coding RNAs in developmental processes.

Also read: Education research topics

Human Biology Research Topics

• Genetic factors influencing susceptibility to infectious diseases.
• Human microbiome and its impact on health and disease.
• Genetic basis of rare and common human diseases.
• Genetic and environmental factors contributing to aging.
• Impact of lifestyle and diet on human health and longevity.

Molecular Biology Research Topics 

• CRISPR-Cas gene editing technology and its applications.
• Non-coding RNAs as regulators of gene expression.
• Role of epigenetics in gene regulation and disease.
• Mechanisms of DNA repair and genome stability.
• Molecular basis of cellular metabolism and energy production.

Research Topics in Biology for Undergraduates

• 41. Investigating the effects of pollutants on local plant species.
• Microbial diversity and ecosystem functioning in a specific habitat.
• Understanding the genetics of antibiotic resistance in bacteria.
• Impact of urbanization on bird populations and biodiversity.
• Investigating the role of pheromones in insect communication.

Synthetic Biology Research Topics 

• Design and construction of synthetic biological circuits.
• Synthetic biology applications in biofuel production.
• Ethical considerations in synthetic biology research and applications.
• Synthetic biology approaches to engineering novel enzymes.
• Creating synthetic organisms with modified functions and capabilities.

Animal Biology Research Topics 

• Evolution of mating behaviors in animal species.
• Genetic basis of color variation in butterfly wings.
• Impact of habitat fragmentation on amphibian populations.
• Behavior and communication in social insect colonies.
• Adaptations of marine mammals to aquatic environments.

Also read: Nursing research topics

Best Biology Research Topics 

• Unraveling the mysteries of circadian rhythms in organisms.
• Investigating the ecological significance of cryptic coloration.
• Evolution of venomous animals and their prey.
• The role of endosymbiosis in the evolution of eukaryotic cells.
• Exploring the potential of extremophiles in biotechnology.

Biological Psychology Research Paper Topics

• Neurobiological mechanisms underlying memory formation.
• Impact of sleep disorders on cognitive function and mental health.
• Biological basis of personality traits and behavior.
• Neural correlates of emotions and emotional disorders.
• Role of neuroplasticity in brain recovery after injury.

Biological Science Research Topics: 

• Role of gut microbiota in immune system development.
• Molecular mechanisms of gene regulation during development.
• Impact of climate change on insect population dynamics.
• Genetic basis of neurodegenerative diseases like Alzheimer’s.
• Evolutionary relationships among vertebrate species based on DNA analysis.

Biology Education Research Topics 

• Effectiveness of inquiry-based learning in biology classrooms.
• Assessing the impact of virtual labs on student understanding of biology concepts.
• Gender disparities in science education and strategies for closing the gap.
• Role of outdoor education in enhancing students’ ecological awareness.
• Integrating technology in biology education: challenges and opportunities.

Biology-Related Research Topics

• The intersection of ecology and economics in conservation planning.
• Molecular basis of antibiotic resistance in pathogenic bacteria.
• Implications of genetic modification of crops for food security.
• Evolutionary perspectives on cooperation and altruism in animal behavior.
• Environmental impacts of genetically modified organisms (GMOs).

Biology Research Proposal Topics

• Investigating the role of microRNAs in cancer progression.
• Exploring the effects of pollution on aquatic biodiversity.
• Developing a gene therapy approach for a genetic disorder.
• Assessing the potential of natural compounds as anti-inflammatory agents.
• Studying the molecular basis of cellular senescence and aging.

Biology Research Topic Ideas

• Role of pheromones in insect mate selection and behavior.
• Investigating the molecular basis of neurodevelopmental disorders.
• Impact of climate change on plant-pollinator interactions.
• Genetic diversity and conservation of endangered species.
• Evolutionary patterns in mimicry and camouflage in organisms.

Biology Research Topics for Undergraduates 

• Effects of different fertilizers on plant growth and soil health.
• Investigating the biodiversity of a local freshwater ecosystem.
• Evolutionary origins of a specific animal adaptation.
• Genetic diversity and disease susceptibility in human populations.
• Role of specific genes in regulating the immune response.

Cell and Molecular Biology Research Topics 

• Molecular mechanisms of DNA replication and repair.
• Role of microRNAs in post-transcriptional gene regulation.
• Investigating the cell cycle and its control mechanisms.
• Molecular basis of mitochondrial diseases and therapies.
• Cellular responses to oxidative stress and their implications in ageing.

These topics cover a broad range of subjects within biology, offering plenty of options for research projects. Remember that you can further refine these topics based on your specific interests and research goals.

Frequently Asked Questions 

What are some good research topics in biology?

A good research topic in biology will address a specific problem in any of the several areas of biology, such as marine biology, molecular biology, cellular biology, animal biology, or cancer biology.

A topic that enables you to investigate a problem in any area of biology will help you make a meaningful contribution. 

How to choose a research topic in biology?

Choosing a research topic in biology is simple. 

Follow the steps:

• Generate potential topics. 
• Consider your areas of knowledge and personal passions. 
• Conduct a thorough review of existing literature.
•  Evaluate the practicality and viability. 
• Narrow down and refine your research query. 
• Remain receptive to new ideas and suggestions.

Who Are We?

For several years, Research Prospect has been offering students around the globe complimentary research topic suggestions. We aim to assist students in choosing a research topic that is both suitable and feasible for their project, leading to the attainment of their desired grades. Explore how our services, including research proposal writing , dissertation outline creation, and comprehensive thesis writing , can contribute to your college’s success.

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49 Most Interesting Biology Research Topics

August 21, 2023

In need of the perfect biology research topics—ideas that can both showcase your intellect and fuel your academic success? Lost in the boundless landscape of possible biology topics to research? And afraid you’ll never get a chance to begin writing your paper, let alone finish writing? Whether you’re a budding biologist hoping for a challenge or a novice seeking easy biology research topics to wade into, this blog offers curated and comprehensible options.

And if you’re a high school or transfer student looking for opportunities to immerse yourself in biology, consider learning more about research opportunities for high school students , top summer programs for high school students , best colleges for studying biomedical engineering , and best colleges for studying biology .

What is biology?

Well, biology explores the web of life that envelops our planet, from the teeny-tiny microbes to the big complex ecosystems. Biology investigates the molecular processes that define existence, deciphers the interplay of genes, and examines all the dynamic ways organisms interact with their environments. And through biology, you can gain not only knowledge, but a deeper appreciation for the interconnectedness of all living things. Pretty cool!

There are lots and lots of sub-disciplines within biology, branching out in all directions. Throughout this list, we won’t follow all of those branches, but we will follow many. And while none of these branches are truly simple or easy, some might be easier than others. Now we’ll take a look at a few various biology research topics and example questions that could pique your curiosity.

Climate change and ecosystems

The first of our potentially easy biology research topics: climate change and ecosystems. Investigate how ecosystems respond and adapt to the changing climate. And learn about shifts in species distributions , phenology , and ecological interactions .

1) How are different ecosystems responding to temperature changes and altered precipitation patterns?2) What are the implications of shifts in species distributions for ecosystem stability and functioning?

2) Or how does phenology change in response to climate shifts? And how do those changes impact species interactions?

3) Which underlying genetic and physiological mechanisms enable certain species to adapt to changing climate conditions?

4) And how do changing climate conditions affect species’ abilities to interact and form mutualistic relationships within ecosystems?

Microbiome and human health

Intrigued by the relationship between the gut and the rest of the body? Study the complex microbiome . You could learn how gut microbes influence digestion, immunity, and even mental health.

5) How do specific gut microbial communities impact nutrient absorption?

6) What are the connections between the gut microbiome, immune system development, and susceptibility to autoimmune diseases?

7) What ethical considerations need to be addressed when developing personalized microbiome-based therapies? And how can these therapies be safely and equitably integrated into clinical practice?

8) Or how do variations in the gut microbiome contribute to mental health conditions such as anxiety and depression?

9) How do changes in diet and lifestyle affect the composition and function of the gut microbiome? And what are the subsequent health implications?

Urban biodiversity conservation

Next, here’s another one of the potentially easy biology research topics. Examine the challenges and strategies for conserving biodiversity in urban environments. Consider the impact of urbanization on native species and ecosystem services. Then investigate the decline of pollinators and its implications for food security or ecosystem health.

10) How does urbanization influence the abundance and diversity of native plant and animal species in cities?

11) Or what are effective strategies for creating and maintaining green spaces that support urban biodiversity and ecosystem services?

12) How do different urban design and planning approaches impact the distribution of wildlife species and their interactions?

13) What are the best practices for engaging urban communities in biodiversity conservation efforts?

14) And how can urban agriculture and rooftop gardens contribute to urban biodiversity conservation while also addressing food security challenges?

Bioengineering

Are you a problem solver at heart? Then try approaching the intersection of engineering, biology, and medicine. Delve into the field of synthetic biology , where researchers engineer biological systems to create novel organisms with useful applications.

15) How can synthetic biology be harnessed to develop new, sustainable sources of biofuels from engineered microorganisms?

16) And what ethical considerations arise when creating genetically modified organisms for bioremediation purposes?

17) Can synthetic biology techniques be used to design plants that are more efficient at withdrawing carbon dioxide from the atmosphere?

18) How can bioengineering create organisms capable of producing valuable pharmaceutical compounds in a controlled and sustainable manner?

19) But what are the potential risks and benefits of using engineered organisms for large-scale environmental cleanup projects?

Neurobiology

Interested in learning more about what makes creatures tick? Then this might be one of your favorite biology topics to research. Explore the neural mechanisms that underlie complex behaviors in animals and humans. Shed light on topics like decision-making, social interactions, and addiction. And investigate how brain plasticity and neurogenesis help the brain adapt to learning, injury, and aging.

20) How does the brain’s reward circuitry influence decision-making processes in situations involving risk and reward?

21) What neural mechanisms underlie empathy and social interactions in both humans and animals?

22) Or how do changes in neural plasticity contribute to age-related cognitive decline and neurodegenerative diseases?

23) Can insights from neurobiology inform the development of more effective treatments for addiction and substance abuse?

24) What are the neural correlates of learning and memory? And how can our understanding of these processes be applied to educational strategies?

Plant epigenomics

While this might not be one of the easy biology research topics, it will appeal to plant enthusiasts. Explore how epigenetic modifications in plants affect their ability to respond and adapt to changing environmental conditions.

25) How do epigenetic modifications influence the expression of stress-related genes in plants exposed to temperature fluctuations?

26) Or what role do epigenetic changes play in plants’ abilities to acclimate to changing levels of air pollution?

27) Can certain epigenetic modifications be used as indicators of a plant’s adaptability to new environments?

28) How do epigenetic modifications contribute to the transgenerational inheritance of traits related to stress resistance?

29) And can targeted manipulation of epigenetic marks enhance crop plants’ ability to withstand changing environmental conditions?

Conservation genomics

Motivated to save the planet? Conservation genomics stands at the forefront of modern biology, merging the power of genetics with the urgent need to protect Earth’s biodiversity. Study genetic diversity, population dynamics, and how endangered species adapt in response to environmental changes.

30) How does genetic diversity within endangered species influence their ability to adapt to changing environmental conditions?

31) What genetic factors contribute to the susceptibility of certain populations to diseases, and how can this knowledge inform conservation strategies?

32) How can genomic data be used to inform captive breeding and reintroduction programs for endangered species?

33) And what are the genomic signatures of adaptation in response to human-induced environmental changes, such as habitat fragmentation and pollution?

34) Or how can genomics help identify “hotspots” of biodiversity that are particularly important for conservation efforts?

Zoonotic disease transmission

And here’s one of the biology research topics that’s been on all our minds in recent years. Investigate the factors contributing to the transmission of zoonotic diseases , like COVID-19. Then posit strategies for prevention and early detection.

35) What are the ecological and genetic factors that facilitate the spillover of zoonotic pathogens from animals to humans?

36) Or how do changes in land use, deforestation, and urbanization impact the risk of zoonotic disease emergence?

37) Can early detection and surveillance systems be developed to predict and mitigate the spread of zoonotic diseases?

38) How do social and cultural factors influence human behaviors that contribute to zoonotic disease transmission?

39) And can strategies be implemented to improve global pandemic preparedness?

Bioinformatics

Are you a data fanatic? Bioinformatics involves developing computational tools and techniques to analyze and interpret large biological datasets. This enables advancements in genomics, proteomics, and systems biology. So delve into the world of bioinformatics to learn how large-scale genomic and molecular data are revolutionizing biological research.

40) How can machine learning algorithms predict the function of genes based on their DNA sequences?

41) And what computational methods can identify potential drug targets by analyzing protein-protein interactions in large biological datasets?

42) Can bioinformatics tools be used to identify potential disease-causing mutations in human genomes and guide personalized medicine approaches?

43) What are the challenges and opportunities in analyzing “omics” data (genomics, proteomics, transcriptomics) to uncover novel biological insights?

44) Or how can bioinformatics contribute to our understanding of microbial diversity, evolution, and interactions within ecosystems?

Regenerative medicine

While definitely not one of the easy biology research topics, regenerative medicine will appeal to those interested in healthcare. Research innovative approaches to stimulate tissue and organ regeneration, using stem cells, tissue engineering, and biotechnology. And while you’re at it, discover the next potential medical breakthrough.

45) How can stem cells be directed to differentiate into specific cell types for tissue regeneration, and what factors influence this process?

46) Or what are the potential applications of 3D bioprinting in creating functional tissues and organs for transplantation?

47) How can bioengineered scaffolds enhance tissue regeneration and integration with host tissues?

48) What are the ethical considerations surrounding the use of stem cells and regenerative therapies in medical treatments?

49) And can regenerative medicine approaches be used to treat neurodegenerative disorders and restore brain function?

Biology Research Topics – Final thoughts

So as you take your next steps, try not to feel overwhelmed. And instead, appreciate the vast realm of possibilities that biology research topics offer. Because the array of biology topics to research is as diverse as the ecosystems it seeks to understand. And no matter if you’re only looking for easy biology research topics, or you’re itching to unravel the mysteries of plant-microbe interactions, your exploration will continue to deepen what we know of the world around us.

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150 Actual Biology Research Paper Topics

Table of contents

• 1 What Is Biology? What Topics Might Biologists Study?
• 2 How to Choose a Topic for Biology Research Paper?
• 3.1 15 Developmental Biology Topics For Research
• 3.2 15 Immune System Biology Research Topics
• 3.3 15 Cell Biology Research Topics
• 3.4 15 DNA Research Topics
• 3.5 15 Molecular Biology Research Topics
• 3.6 15 Neurobiology Research Topics
• 3.7 15 Abortion, Human cloning, and Genetic Researches Topics
• 3.8 15 Environmental and Ecology Topics for Your Research
• 3.9 15 Plant Pathology Biology Research Topics
• 3.10 15 Animals Biology Research Topics
• 3.11 15 Marine Biology Research Topics
• 3.12 15 Zoology Research Topics
• 3.13 15 Genetics Research Topics
• 3.14 15 Biotechnology Research Topics
• 3.15 15 Evolutionary Biology Research Topics

Biology is one of the most magnetic fields of study these days. If you want to be a biologist or scientist in the future, there is no better time to start than right now. Biology research topics covered in this article will keep you busy and interested. Writing a research paper is one of the best ways to dip your toes into the field. Before doing that, you need to know some good topics for the research paper . They should be suitable for biology students rather than cutting-edge researchers. On Papersowl.com , we provide as many biology research paper examples as possible so that you have a huge choice.

What Is Biology? What Topics Might Biologists Study?

Biology is simply the study of everything that has a form of life. It includes investigations on plants, animals, and everything found in the environment. It is about studying how life forms grow, develop, and interact with each other. Biology essay topics for research encompass all these and more.

This science uncovers many fields where various life forms are studied. It makes sense to look through these fields to help you decide which suits you the best.

Plant Biology research topics are about studying the plants around us. They disclose information about their existence as a part of the ecosystem, their life cycle, resources they can give us, their ability to preserve them from climate changes, and so on. There are many ideas to choose from, but you must focus on a specific one.

Human Biology research topics are all about us. These topics focus on different body parts, such as the human brain, the human immunological system, the nervous system, etc. In addition, you can discuss DNA modifications in humans and explain why genetic disorders occur in your research projects. Various cell research is also common today.

Biology research topics on the environment are in great demand too. For example, climate change is becoming a more significant threat every day. By studying environmental topics in biology for projects and research, we can come up with ways to combat them and preserve ecosystems.

Microbiology research topics delve into things we can’t see. There are trillions of microbes and bacteria all around us. Knowing about them is essential to understanding what makes us sick and how to fight against them. All microbiology research paper topics are pretty complicated yet very engaging to include in your paper research.

Molecular biology topics dive even deeper into the level of atoms and molecules. The various medicines and drugs we take were all created through molecular-biology research. It is one of the areas full of ideas, but there is yet to be much evidence. Science is advancing in this realm but still needs a lot of time. Topics of molecular biology will need days for research only.

Keep in mind that there are more ideas and variations of this science. We offer more examples in further sections of the article about developmental biology, marine biology, evolutionary biology, etc. Explore them and make your writing appealing and meaningful in the eyes of a professor.

How to Choose a Topic for Biology Research Paper?

When choosing a biology project topic, you must be aware of one or more fields of science. Biology research is critical to the present world. By doing research, we can learn more about genetic disorders, immune disorders, mental health, natural disease resistance, etc. Knowing about each of these could save lives in the future.

For those who may not have the time or resources to do their own research, there are research paper writing services that can provide assistance with the project. And we are always here to help you find your own topic among interesting biology research topics. Here we prepared some useful tips to follow.

• Tip 1: The level of interest matters Pay attention to one that interests you, and you might have ideas on how to develop the topic. Passion is fundamental in research, after all.
• Tip 2: Explore the topic Try to narrow things down a bit. If the topic is too broad, you may not be able to cover all aspects of it in one research paper. If it is too narrow, the paper could end up too short. Analyze the topic and the ways to approach it. By doing so, you can strike a balance between the two.
• Tip 3: Discover the recent developments To make your research paper touchable with the present day, you must explore the latest developments in the field. You can find out what kind of research has been done recently by looking at journals. Check out research papers, topics, research articles, and other sources.
• Tip 4: Ensure to get enough resources When choosing a topic, make sure it has plenty of resources available. For example, a research paper on xenobiology or cutting-edge nanobiology might sound attractive. Still, you might have difficulties getting data and resources for those unless you are a researcher at a government lab. Data, resources, complex numbers, and statistics are all invaluable to writing a paper about these topics.

That is why we have selected a range of biological topics. The topics on this list are all hopefully exciting topics for research you could write an excellent paper on. We should also add that easy biology topics to research are rare, and a writer usually needs days to prepare and start writing. Yes, biology research topics for high school students are a bit easier, but still, they need time to explore them.

On the other hand, biology research topics for college students are far more complex and detailed. Some people prefer evolutionary biology research paper topics, and we can agree with this claim. These research areas do have a lot of potential and a lot of data to support the claims. Others prefer cell biology research topics that are a bit specific and fun. Anyway, with this article’s list of easy biology research topics, you will surely find the one matching your interest.

For those who may not have the time or resources to do their own research, there are provide assistance with the project.

Top Research Biology Paper Topics

This section contains a large selection of research biology paper topics. You will be able to find one that will suit you the best. The only thing left is to decide what variation of science you prefer. Whether you’re interested in microbiology, genetics, or any other type of science, you’ll find a topic to get you started. If you’re ever stuck or need some extra help, you can always pay someone to write your paper for you. So, take a look, and choose the perfect topic for your project!

15 Developmental Biology Topics For Research

Exploring the processes of how cells grow and develop is exciting. The human body contains millions of cells, and it’s interesting to research their behavior under different conditions. If you feel like writing about it, you can find some interesting biology topics below.

• How do stem cells form different tissues?
• How are tumors formed?
• Duplication of genomes
• Plasticity of development
• Different birth defects
• Interactions between genes and the environment
• Anticancer drugs mixtures
• Developmental diseases: Origin
• Drosophila Oogenesis
• Most deadly viruses
• Most deadly bacteria in the world
• How do germs affect cells?
• How does leukemia start?
• Development of the cardiovascular system in children
• How do autoimmune diseases start and affect the human body?

15 Immune System Biology Research Topics

For decades, many scientists and immunologists have studied the human immune system and tried to explain its reaction to various pathogens. This area allows you to deepen into it and reveal how a body protects itself from harmful impact. Look over the biology research questions below and find your match-up.

• How does the human body’s immune system work?
• The human immune system: How to strengthen it?
• What makes the immunological system weaker?
• The notion of auto-immune diseases and their effect on the body’s immune system
• The global HIV/aids epidemic
• What methods are used to prevent the spread of hives?
• Living with auto-immune diseases
• Genetics and the immune system: effects and consequences
• How do immune disorders affect the body, and what causes them?
• Are allergies signs of worrying about an immune disorder?
• DNA modification in solving immune disorders
• Stress as the biggest ruiner of the immunological system
• Vaccines as strong supporters of the immunological system
• The perception of vaccines in society
• Why do some people refuse vaccines and put others around them in danger?

15 Cell Biology Research Topics

Cell study might seem challenging yet very engaging. It will be a good idea to compare various types of cells and compare them in animals and plants. Make your choice from the list of cell biology research topics below.

• The structure of an animal cell
• Mitochondria and its meaning in cell development
• Cells classification and their functions
• Red blood cells and their function in transporting oxygen
• White blood cells and their responsibility to fight diseases
• How are plant cells different from animal cells?
• What would it be if animals had a function to photosynthesize?
• Single-celled organisms: What is it, and how do they work?
• What processes do cells go through in division?
• Invasion of bacteria into the body
• Viruses – alive or not?
• Fungi: their reproduction and distribution
• Cancer cells: Why are they so dangerous?
• What methods are used to kill cancer cells?
• The role of stem cells and their potential in a body

15 DNA Research Topics

The variety of biology research topics for college students might impress you a lot. This is a science with a large field of investigation, disclosing much scientific information to use in your project. The notion of DNA and its gist are also excellent options to write about.

• The structure of the human DNA
• The main components of a DNA chain
• Why does DNA have a double-helix spiral structure?
• The purpose of chromosomes
• MRNA and its relation to DNA
• Do single-celled organisms have DNA?
• Do viruses have DNA?
• What happens if you have too many or too few chromosomes?
• Analyzing the structure of DNA using computers
• Uses for the DNA of extinct organisms like mammoths and dinosaurs
• Storing non-genetic information in DNA
• Can you write a computer program into human DNA?
• How does radiation affect DNA?
• Modifying DNA to treat aids
• Can we fight cancer through DNA modification?

15 Molecular Biology Research Topics

Do you prefer to research molecules’ chemical and physical composition? We gathered some molecular biology research topics to make your choice easier.

• The structure and components of a gene
• How do molecules move in and out of a cell?
• The basic building blocks of life
• How are drugs designed for humans?
• How is a vaccine designed to target a specific disease?
• Dominant genes vs. recessive genes
• Prion disease – why is it so dangerous?
• Hormones and their function in the body
• Developing artificial hormones from other animals
• How to carry out a western blot?
• Testing and analyzing DNA using PCR
• The three-dimensional structure of a molecule
• What is DNA transcription, and how is it used?
• The structure of a prion
• What is the central dogma of molecular biology?

15 Neurobiology Research Topics

The more you dive into science, the more exciting things you find. That’s about biology. Here, you can choose biology research topics for high school and try to reveal more simply.

• Nervous system: its structure and function
• Neurons as unique cells playing a central role in the nervous system
• What is the maximum reaction speed in a human?
• Reaction speed: how to improve it?
• Research on Organic Farming
• What are the symptoms of Alzheimer’s disease?
• Why do we feel happy or sad?
• Headaches in terms of Neurobiology
• What are the reasons for neurobiological degeneration?
• Myths and reality of Amnesia
• What causes Alzheimer’s Disease, and what are the consequences of the disease?
• What is the treatment for Spinal Cord Injury?
• Studies on Narcolepsy and Insomnia: What are the causes?
• Is there a connection between Mental Health and Neurobiology?
• Emotions in terms of their reflection in the brain

15 Abortion, Human cloning, and Genetic Researches Topics

There are so many scientific researches and theories that society accepts or neglects. You can operate different notions and try to explain them, reflecting their advantages and downsides for a human being. We gathered some enticing life science research topics for high school students that might interest you.

• The controversy around abortion: legal or not?
• Can abortion be safe?
• Human cloning – reality vs. science-fiction
• The goals of cloning humans
• Are human cloning and transplantation ethical?
• Having a “perfect child” through gene therapy: Is it a myth?
• How far has gene therapy gone in genetic research?
• Advantages and disadvantages of gene therapy
• How gene therapy can help beat cancer
• How gene therapy can eliminate diabetes
• The opportunity to edit genes by CRISPR
• DNA modifications in humans to enhance our abilities – an ethical dilemma
• Will expensive gene therapy widen the gap between the rich and the poor?
• Cloning: the good and the Bad for a Generation
• The disadvantages of cloning
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15 Environmental and Ecology Topics for Your Research

The nature around us is so enormous and includes many branches to investigate. If you are keen on the environment and how ecology affects it, the list of follow-up biology paper topics might be helpful to you.

• The theory of evolution
• How does natural selection work?
• How do living organisms adapt to their environment?
• The concept of divergent and convergent evolution
• Building a sustainable environment
• Development of environment-friendly cities
• How to control population growth?
• Why have recycling resources become so essential in the modern world?
• The effect of plastic on the environment
• What are the global consequences of deforestation?
• What can we expect when losing biodiversity?
• Ecological damage: How to prevent it?
• How can GMO products affect ecology?
• Cloning endangered or extinct species: Is it a good idea?
• Is climate change the main reason for disrupting ecology?

15 Plant Pathology Biology Research Topics

Many factors impact human health and the quality of food products matters. These easy biology research topics will be useful if you want to describe the connection between those two concepts.

• How do plants protect themselves from diseases?
• How to increase the plant’s resistance to diseases?
• Diseases distribution among plants
• The banana pandemic
• How do herbicides influence plants?
• Corn blight
• Can any plant diseases affect humans?
• The issue of stem rust and its impact on wheat
• What approaches are used to struggle against invasive plants and affected weeds?
• Fertilizers: their pros and cons on plants
• Plant disease genetics: its system and structure
• What is the connection between ecological changes and plant diseases?
• Modifications on food production because of plant diseases
• How do fungal and viral diseases appear in plants?
• The sweet potato virus

15 Animals Biology Research Topics

It’s hard to find someone who doesn’t like animals. If you are curious about animals scientifically, here you are with biology research paper topics in this field.

• Classification of animals
• Land-based life: its evolution history
• Controversies about keeping animals as pets
• Is it ethical to test drugs and products on animals?
• Why do nature reserves against zoos?
• Evidence on prehistoric aquatic animals growing giant
• What species of animals are vegan?
• Animals and their social behavior
• Primate behavior
• How intelligent can other primates be?
• Are wolves and dogs intelligent?
• Domesticating animals
• Hibernation in animals
• Why animals migrate
• Should we bring back extinct animals?

15 Marine Biology Research Topics

The marine theme is engaging as it reveals so many interesting facts about life forms dwelling under the water. You can make your paper look captivating using biology topics in marine below.

• How acidification affects aquatic environments
• Evolution in the deep sea
• What’s the meaning of camouflage mechanism in sea life?
• Consequences of oil spills on marine life
• Oldest marine species
• How do whales communicate with each other?
• How blind fish navigate
• Are marine shows and aquariums ethical?
• The biology and life cycle of seabirds
• How jellyfish are immortal
• Plankton ecology
• Difference between freshwater and seawater marine life
• Coral reefs: their importance and evolution
• Saving and restoring coral reefs
• Life in the deep-sea ocean trenches

15 Zoology Research Topics

Zoology can be an excellent choice to write about if you are close to animal studies. Look at biology topics to research and choose the one that fits your interest most.

• Asian elephants and human speech patterns
• Oyster genomes and adaptation
• Darwin’s work in the Galápagos Islands
• Asian carp: Invasive species analysis
• Giant squids: Fact vs. fiction
• Coyote and wolf hybrid species in the United States
• Parasites and disease
• Migration patterns of killer bees
• The treatment of species in Melville’s Moby Dick
• Biodiversity and plankton
• The role of camels and the development of Africa and the Middle East
• Muskellunge and adaptive creek mechanisms to small water
• Ants and cooperative behavior among species
• Animal communication and the origin of language
• Speech in African Gray Parrots

15 Genetics Research Topics

Writing about modifications caused on the gene level is pretty challenging but very fascinating. You can select one among the biological questions for research and bring up a meaningful paper.

• Genetics and its role in cancer studies
• Can genetic code be confidential?
• Is it possible to choose the sex of a person before birth?
• Genetics as a ray of hope for children with an intellectual disability
• What factors in human genetics affect behavior?
• Is it somehow possible to improve human personality through genetics?
• Are there any living cells in the gene?
• Fighting HIV with gene mutations
• Genetic mutations
• How addictive substances affect genes
• Genetic testing: is it necessary?
• Cloning: positive or negative outcome for future generations
• Pros and cons of genetic engineering
• Is the world ready for the bioethics revolution?
• The linkage between genetics and obesity

15 Biotechnology Research Topics

The way scientists conduct research today is magnificent. Implementing high-tech innovations in biology research brings new opportunities to study the world. What are these opportunities? Explore biotechnology research topics for college students and disclose the best options for you.

• Biotechnology used in plant research
• What is the contribution of biotechnology to food?
• Pharmacogenetics: What is it, and how it works?
• How are anti-cancer drugs produced to be effective?
• Nanotechnology in DNA: How to isolate it?
• Recent nanotechnology used in HIV treatment
• What biotech apps are used to detect foodborne pathogens in food systems?
• Genotypes research: Why are they tolerant and sensitive to heavy metal?
• High-tech solutions in diagnosing cancer
• Forensic DNA and its latest developments
• Metabolic changes at the level of cells
• Nanotechnology in improving treatments for respiratory viruses
• The latest biotech discoveries
• Digital evolution: bioresearch and its transformation
• The concept of vaccine development

15 Evolutionary Biology Research Topics

Knowing how life forms started their existence is fundamental. And more interesting is to look through the evolution of many processes. If you find this trend of research more engaging, we outlined evolutionary biology research paper topics to diversify your choice.

• Darwin’s concept’s impact on science
• The evolution concept by Lamarck
• Origins of the evolutionary theory
• Evolution acceptance: a belief vs. a theory?
• Evolutionary in microbiology
• Development of robotics
• Revealing differences: human brain & animal brain
• Preservation of biological resources
• Transformations in aging
• Adaptive genetic system
• Morphometrics’ history
• Developmental theory and population genomics
• Bacteria ecology’s evolution
• Biological changes: impact and evolution
• Infectious diseases and their profession

The world of science and biology is vast, making research tedious. Use our list of interesting biology research topics to choose the best issue to write your own paper.

However, it is still hard to prepare a high-quality biology research paper, even with a brilliant topic. Not all college students can do it. Do you feel like you need some help? Then buy biology paper from our professional writers! Our experts will choose the best biology experimental research topics for you and can bring up top-level papers within the shortest time. Additionally, if you need help with a statistics project related to biology, our team of experienced professionals is equipped to provide you with the utmost quality of research and analysis.

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212 Unique Biology Research Topics For Students And Researchers

Every student studying something related to biology — botany, marine, animal, medicine, molecular or physical biology, is in an interesting field. It’s a subject that explores how animate and inanimate objects relate to themselves. The field unveils the past, the present, and what lies in the future of the relationship between the living and nonliving things.

This is precisely why you need custom and quality biology topics for your college and university essay or project. It’ll make it easy to brainstorm, research, and get to writing straight away. Before the deep dive, what is biology?

What Is Biology?

Everyone knows it’s the scientific study of life, but beyond that, biology facilitates the comprehension of living and nonliving things. It’s a branch that explores their anatomy, behavior, distribution, morphology, and physiology.

For example, it understands how genes are classified and constituted into generations. It encompasses various branches, including botany, medicine, genetics, ecology, marine biology, zoology, and molecular biology.

Here are what some of these mean:

Botany: This study of plants examines their structure, physiology, ecology, economic importance, and distribution, among others. It also deals with their biochemical processes, properties, and social interactions between plants. It extends to how plants are vital for human life, survival, and growth and how they play a significant role in stabilizing environmental health. Zoology: Zoology studies animal behavior, brain, structure, physiology, class, and distribution. It’s the general study of the lives of both living and extinct animals. It explains animal classification, the animal kingdom, evolution, habitat, embryology, and life span. Physiology: Physiology deals with the daily functions of the human body: How it works and the factors that make it work. It examines molecular behavior, the chemistry and physics behind locomotion, and how the cells in the living organisms’ body function. It helps understand how humans and animals get sick and what can be done to alleviate pain. Microbiology: Dealing with microorganisms, it examined how viruses, algae, fungi, bacteria, protozoa, and slime molds become parts of human life. They’re regarded as microbes, which play substantial roles in the human biochemical processes, including climate change, biodegradation, biodeterioration, food spoilage, biotech, and epidemiology. Marine Biology: This is the scientific study of organs in the sea. It understands their family classification, how they survive, and what makes wild marine animals different from domesticated and consumable ones. It also explores their interaction with the environment through several processes. The marine biologist studies marines in their natural environment, collects data on their characteristics, human impact on their living, and how they relate with themselves.

Now that you know all these, here are some custom biology topics to research for your university or college essay and paper.

Controversial Biology Topics

There are many controversial subjects in every field, and biology isn’t exempt from controversy. If you’d like to create an original essay through diverse opinions, here are biology topics for you:

• What are your thoughts on the post-Roe V Wade world?
• How can the post-Roe V Wade policy affect developing countries looking up to America for their laws?
• Abortion and feminism: discuss
• Does saving life justify cloning?
• Explain the principle of abortion in medical practice
• The effects of cloning in medicine
• How does genetics contribute to obesity?
• Explain why a parent could have Hepatitis B virus and only one of five offspring have the virus
• Is homosexuality really in the gene?
• How does depression correlate with genetics?
• Additives and how they affect the genes
• Examine how genetic mutations work
• Discuss the grounds that you could prove for legalizing human cloning
• Which is more immoral: Human or animal cloning?
• How is nanotechnology different from biotechnology?
• Discuss the manifestation of nanotechnology in science
• Explain three instances where public opinion has held back scientific inventions
• How does transgenic crop work?
• Would you say genetically modified food is safe for consumption?
• Explain why sexual abuse leads to trauma.

Biology Research Paper Topics

You’d need to write an extensive paper on biology one day. This could be when you’re in your final year in college or the university or submitting to a competition. You’d need Biology topics to research for brainstorming, and here are 30 of them:

• Stem cells and tissue formation processes
• Why are there different congenital disabilities?
• Mixtures in anticancer drugs?
• What are the complexities of existing HIV drugs?
• What is the contribution of chemotherapy to cancer?
• Examine the chemotherapy process and why it doesn’t work for some patients.
• Explain the origin of developmental diseases
• How do germs affect the cells?
• What are the consequences of the sun on the white person’s and black person’s skin?
• Why are some diseases treatable through drugs while some are not?
• Scientific lessons learned from COVID-19 and ideas to tackle the next virus
• If animals are carriers of the virus, what should be done to them?
• Examine five animals in extinction and what led to it
• Discuss the subject of endangered species and why people should care
• Is a plant-based diet sustainable for human health?
• Account for the consequence of living on Mars on human health
• Discuss the inconveniences involved in space travel
• How does space flight contribute to environmental disasters
• Discuss the emergence of leukemia
• Explain how the immune systems in humans work
• Evaluate the factors that weaken the immunological system
• What would you consider the deadliest virus?
• Autoimmune: what is it, origin and consequences
• Immune disorder: origin and how it affects the body
• Does stress affect the ability to have sex?
• Contribution of vaccine to eradicating disease: Discuss
• What are the complexities in taking the Hepatitis B vaccine while being positive?
• Allergies: why do humans have them?
• DNA modification: how does it work?
• Explain the misconceptions about the COVID-19 vaccines.

Interesting Biology Topics

Biology doesn’t have to be boring. Different aspects of biology could be fun to explore, especially if you’ve had a flair for the study since your elementary school classes.

You can either write an essay or paper with the following interesting biology research topics:

• Human emotions and conflicts with their intellectual intelligence
• Emotions: Its influence on art and music and how the perception of art influences the world
• The consequences of marijuana and alcohol on teenagers
• Compare and contrast how alcohol affects teenagers and adults
• Discuss the contributions of neuroscience to the subject of emotional pain
• Explain how the brain process speech
• Discuss the factors that cause autism
• Explain what is meant when people say humans are animals
• Why do scientists say humans are pessimists?
• Factors contributing to the dopamine levels human experience
• How does isolation affect the human brain?
• What factors contribute to instinctive responses?
• Noise pollution: how it affects living organisms
• Fire ecology: The contributions of plants to fire outbreak
• Explain the science behind how hot temperature, soil, and dry grass start a fire
• Microbes: what do you understand by bioremediation?
• Explain urban ecology and the challenges it pokes to solve
• Discuss how excessive internet usage affects the human memory
• Evaluate how conservation biology contributes to the extinction prevention efforts
• Discuss the role of satellites and drones in understanding the natural world
• Why do we need space travel and studies?
• Explain the limitations of limnology studies
• What are infectious-disease-causing agents all about?
• Discuss what epigenetics studies encompass
• Why is cancer research essential to the world?
• Discuss climate change: Governments are not interested, and there is no alternative
• How is behavioral science studies a core part of the understanding of the world?
• Discuss the issues with genetic engineering and why it’s a challenge
• Evaluate the strengths and weaknesses in the arguments for a plant-based diet
• Create a survey amongst students of biology asking why they chose to study the course.

Biology Research Topics For College Students

If you find any of the above beyond your intellectual and Research capacity, here are some topics you can handle. You can use these for your essays, projects, quizzes, or competitions.

These custom yet popular biology research topics will examine famous personalities and other discourse in biology:

• Effects of the human hormone on the mind
• Why do men get erect even when they’re absentminded?
• How does women’s arousal work?
• How can melatonin be valuable for therapy?
• Risky behavior: Hormones responsible for the risk
• Stem and cloning: what is the latest research on the subject?
• Hormones: changes in pregnancy
• Why do pregnant women have an appetite for random and remote things?
• The role of physical activities in hormone development
• Examine the benefits and threats of transgenic crops
• The fight against COVID-19: assess current successes
• The fight against smallpox: assess current successes
• The fight against HIV: history, trends, and present research
• Discuss the future of prosthetic appliances
• Examine the research and the future of mind-controlled limbs
• What does cosmetic surgery mean, and why is it needed?
• Analyze the meaning and process of vascular surgery
• Discuss the debate around changes in genital organs for males and females in transgender bodies
• How do donors and organ transplants work?
• Account for the work of Dr. Malcom E Miller
• Discuss the contribution of Charles Darwin to human evolution
• Explain the trends in biomedicine
• Discuss the functions of x-rays in botany
• Assess the most efficient systems for wildlife preservation
• Examine how poverty contributes to climate hazards
• Discuss the process involved in plant metabolism
• The transformation of energy into a living thing: discuss
• Prevention for sexually transmitted disease: What are the misconceptions?
• Analyze how the human body reacts to poison
• Russian Poisoning: What are the lessons scientists must learn?
• COVID-19: Discuss the efforts by two or three governments to prevent the spread
• Discuss the contributions of Pfizer during the pandemic.

Marine Biology Research Topics

This subject explains orgasms in the sea, how they survive, and their interaction with their environment. If you have a flair for this field, the following Biology research topics may interest you:

• Discuss what quantitative ecology through modeling means
• Smallest diatoms and marine logistics: discuss
• How is the shark studied?
• Acidification of seas: Causes and consequences
• Discuss the concept of the immortality of Jellyfishes
• Discuss the differences between seawater and freshwater in marine study
• Account for some of the oldest marine species
• Discuss the evolution of the deep sea
• Explain whales’ communication techniques
• What does plankton ecology encompass?
• The importance of coral reefs to seawater
• Challenges that encompass geological oceanography
• How tourism affects natural animal habitat
• Discuss some instances of the domestication of wild marine animals
• Coastal zone: pros and cons of living in such areas
• How do sharks perceive enemies?
• Analyze why some animals can live in water but can’t live on land
• Explain how plants survive in the sea
• Compare and contrast the different two species of animals in the water
• How can marine energy be generated, stored, and used?

Molecular Biology Research Topics

Focusing on the construct of cells and analysis of their composition, it understands the alteration and maintenance of cellular processes. If you’d like to focus on molecular biology, here are 15 good biology research topics for you:

• Ethical considerations in molecular genetics
• Discuss the structure and component of the gene
• Examine the restrictions in DNA
• What are the peculiarities in modern nucleic acid analysis
• What goes into the Pharmaceutical production of drugs
• Evaluate the building blocks of life
• Discuss the systems of RNA translation to protein
• PCR: How DNA is tested and analyzed
• Why is prion disease so dangerous?
• Compare and contrast recessive genes vs. dominant genes
• Can there be damage to the human DNA, and can it be repaired?
• Constraints in the research of microarray data analysis
• Protein purification: How it evolves
• Objectives of nucleic acid
• Explain the structure of a prion.

Biology Research Topics For High School

Your teachers and professors will be awed if you create impeccable essays for your next report. You need to secure the best grades as you move closer to graduation, and brainstorming any of these popular biology research topics will help:

• Identify the most endangered species
• The challenges to animal extinction
• What are the things everyone should know about sea life?
• Discuss the history of genetics
• Explain the biological theory of Charles Darwin
• How did the lockdown affect social interaction?
• Why do some people refuse the vaccine?
• Origin of genetics
• What is animal hunting, and why is it fashionable
• Explain the evolution of a virus
• Role of lockdown in preventing deaths and illnesses
• Invasive species: What does it mean?
• Endangered animals: How do they survive in the face of their hazards?
• Lockdown and their role in reducing coronavirus transmission
• Vaccine distribution: Ideas for global distribution
• Why can viruses become less virulent?
• Discuss the evolution of the world
• Explain the evolution of the planet
• Explain what Elon Musk means when he says life on Mars is possible
• What does herd immunity mean?
• Flu: why is there a low incidence in 2020?
• Relationship between archaeology and biology
• Antiviral drug: What it means
• Factors leading to the evolution of humans
• Give instances of what natural selection means
• What is considered the dead branches of evolution
• Whale hunting: What it means and the present trends
• Who is Stephen Jay, and what is his role in paleontology?
• Origin of diseases: why must humans fall sick?
• Why are humans called higher animals?

Human Biology Research Topics

Human biology understands humans and their relationship between themselves and their environment. It also studies how the body works and the impediments to health. Here are some easy biology research topics to explore on the subject:

• How do gut bacteria affect the brain?
• What are the ethical concerns around organ transplants?
• The consequence of alcohol on the liver
• The consequences of extreme salt on the human body
• Why do humans need to deworm regularly?
• The relationship between obesity and genetics
• Genetically modified foods: Why are they needed?
• How sun exposure affects human skin
• Latest trends: Depression is hereditary
• Influence of music on the human brain
• What are the stages of lung cancer
• Forensic DNA: latest trends
• How visual consumptions affect how humans think
• What is the process that leads to pregnancy?
• Explain the role of nanotechnology in HIV research
•  Discuss any experiment with stem cells you know about
• Explain how humans consume food
• Discuss the process of metabolism as well as its criticality to human health
• Explore the consistent challenges technology poses to human health
• Explain the process of body decay to a skeleton.

Cell Biology Research Topics

There are many evolutionary biology research paper topics formed not by the nomenclature but for what they stand for. Cell biology is one of the most complex branches of the field.

It examines minor units and the living organisms that make them up. The focus is on the relationship between the cytoplasm, membrane, and parts of the cell. Here are some topics to explore for your scientific dissertation writing :

• How does chromatin engage in the alterations of gene expression?
• What are the usual cell infections, and why does the body have immunity defections?
• Identify and account for the heritage of Robert Brown in his core career focus
• Explain the structure of the animal cell and why It’s what it is
• Identify the cells in the human body as well as their functions
• Explain a scenario and justify the context of animals photosynthesizing like plants
• Why do bacteria invade the body, and how do they do it?
• Why are mitochondria considered the powerhouse of the cell
• Use the molecular analysis tool to explain multicellular organisms
• Examine how the White blood cells fight disease
• What do you understand about the role of cell biology in the treatment of Alzheimer’s Disease
• What are the latest research methods in cell biology?
• Identify the characteristics of viruses and why they threaten human existence.
• Discuss the differences between DNA and RNA
• What part of the body is responsible for human functionality for as long as the individual wants?

Get Biology Research Help As Soon As Possible

Creating the best essays or papers is easier now that you have custom biology research topics. However, you may still need support writing your paper beyond these topic ideas. After all, the first stage of writing like experts is brainstorming ideas and researching which is most feasible to write about.

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Home » 350+ Biology Research Topics

350+ Biology Research Topics

Biology is a vast field of study that explores the diverse aspects of life, from the smallest organisms to the complex ecosystems they inhabit. With new discoveries being made every day, the field of biology is constantly evolving and expanding. As a result, there are numerous research topics within biology that can capture the imagination of students, researchers , and professionals alike. Whether you’re interested in genetics, ecology, microbiology, or any other subfield of biology, there is no shortage of fascinating topics to explore. In this post, we will discuss some of the most compelling biology research topics that you can delve into.

Biology Research Topics

Biology Research Topics are as follows:

• The role of gut microbiota in human health and disease.
• The effects of climate change on animal behavior and physiology.
• The molecular mechanisms of cancer development and progression.
• The evolutionary origins of human language.
• The impact of pesticides on insect populations and ecosystems.
• The genetic basis of aging and longevity.
• The ecological importance of microbial communities in soil.
• The physiology and behavior of marine mammals.
• The molecular mechanisms of viral infections.
• The evolutionary history of flowering plants.
• The ecological impacts of invasive species.
• The role of epigenetics in gene regulation and disease.
• The evolution of social behavior in animals.
• The physiology and ecology of birdsong.
• The impact of antibiotics on gut microbiota and human health.
• The role of the microbiome in psychiatric disorders.
• The evolutionary history of human migrations.
• The ecological and physiological effects of light pollution on animals.
• The mechanisms of cell division and differentiation.
• The ecological impacts of deforestation.
• The molecular mechanisms of drug addiction.
• The genetic basis of plant resistance to pests and diseases.
• The evolutionary history of human diet and nutrition.
• The molecular mechanisms of neurodegenerative diseases.
• The ecology and evolution of sexual selection.
• The physiological and behavioral effects of air pollution on animals.
• The role of epigenetics in plant development and stress response.
• The evolutionary history of animal domestication.
• The molecular mechanisms of genetic diseases.
• The ecological impacts of climate change on plants.
• The evolutionary history of human mating systems.
• The physiological and behavioral effects of noise pollution on animals.
• The genetic basis of intelligence and cognitive abilities.
• The ecological and physiological effects of ocean acidification on marine organisms.
• The molecular mechanisms of immune system function and dysfunction.
• The evolutionary history of human social structures.
• The ecological impacts of plastic pollution on marine ecosystems.
• The genetic basis of animal migration.
• The physiological and behavioral effects of light and dark cycles on animals.
• The ecological and evolutionary dynamics of symbiosis.
• The molecular mechanisms of gene regulation and expression.
• The evolutionary history of human disease resistance.
• The ecological impacts of overfishing on marine ecosystems.
• The genetic basis of animal communication.
• The physiological and behavioral effects of temperature changes on animals.
• The ecological and evolutionary dynamics of parasitism.
• The molecular mechanisms of circadian rhythms.
• The evolutionary history of human social cognition.
• The ecological impacts of urbanization on wildlife.
• The genetic basis of antibiotic resistance in bacteria.
• The impact of climate change on insect population dynamics.
• The role of the microbiome in the development of autoimmune diseases.
• The genetic basis of complex human diseases such as diabetes and heart disease.
• The evolution of plant secondary metabolites and their ecological functions.
• The effects of anthropogenic noise on animal communication and behavior.
• The molecular mechanisms of protein synthesis and folding.
• The role of RNA in gene expression and regulation.
• The ecology and evolution of microbial symbioses in plants.
• The physiological and behavioral effects of air temperature changes on animals.
• The genetic basis of crop domestication and improvement.
• The evolution of reproductive strategies in animals.
• The impacts of plastic pollution on terrestrial ecosystems.
• The molecular mechanisms of stem cell differentiation and regeneration.
• The ecological dynamics of predator-prey interactions.
• The role of gut microbiota in the regulation of host metabolism.
• The genetic basis of host-pathogen coevolution.
• The evolution of social cognition and cooperation in animals.
• The ecological and physiological effects of wildfires on ecosystems.
• The molecular mechanisms of transcriptional regulation in eukaryotic cells.
• The role of microorganisms in soil nutrient cycling and ecosystem functioning.
• The genetic basis of plant-pathogen interactions.
• The ecology and evolution of microbial communities in the ocean.
• The physiological and behavioral effects of water pollution on aquatic organisms.
• The molecular mechanisms of protein degradation and turnover.
• The impact of urbanization on pollinator populations and plant-pollinator interactions.
• The genetic basis of insecticide resistance in pests.
• The evolution of animal cognition and perception.
• The ecological and evolutionary dynamics of host-parasite interactions.
• The role of epigenetic modifications in plant adaptation to environmental stress.
• The physiological and behavioral effects of endocrine disruptors on animals.
• The molecular mechanisms of DNA replication and repair.
• The impact of ocean warming on coral reef ecosystems.
• The genetic basis of animal personality traits.
• The ecology and evolution of microbial symbioses in animals.
• The physiological and behavioral effects of light quality on plants.
• The molecular mechanisms of RNA editing and splicing.
• The role of microbial communities in plant-pathogen interactions.
• The ecological and evolutionary dynamics of seed dispersal.
• The genetic basis of animal coloration and pattern.
• The impact of climate change on plant phenology and productivity.
• The molecular mechanisms of signal transduction in cells.
• The role of microbial communities in the human gut-brain axis.
• The ecology and evolution of animal migrations.
• The physiological and behavioral effects of chemical pollution on animals.
• The genetic basis of animal development and morphogenesis.
• The evolution of animal social behavior and communication.
• The ecological dynamics of plant-pollinator networks.
• The molecular mechanisms of intracellular trafficking and transport.
• The role of microbial communities in the degradation of pollutants.
• The ecological and evolutionary dynamics of species interactions in ecological communities.
• The role of epigenetics in cancer development and progression.
• The molecular basis of antibiotic resistance in bacteria.
• The impact of climate change on biodiversity and ecosystem functioning.
• The genetic basis of aging and age-related diseases.
• The evolution of social organization in primates.
• The ecological dynamics of plant-fungal interactions.
• The role of microbiota in immune system development and function.
• The molecular mechanisms of DNA damage and repair.
• The physiological and behavioral effects of climate change on marine organisms.
• The genetic basis of human variation and diversity.
• The evolution of sexual selection and mate choice in animals.
• The ecological and evolutionary dynamics of species invasions.
• The role of microbiota in brain function and behavior.
• The molecular mechanisms of immune system activation and regulation.
• The physiological and behavioral effects of pollution on wildlife.
• The genetic basis of behavioral disorders and mental illness.
• The evolution of plant-pollinator mutualisms.
• The ecological dynamics of predator-prey coevolution.
• The role of microbiota in metabolic diseases such as obesity and diabetes.
• The molecular mechanisms of protein-protein interactions and signaling.
• The genetic basis of complex traits such as intelligence and personality.
• The evolution of animal communication and language.
• The ecological and evolutionary dynamics of mutualistic interactions in ecological communities.
• The role of microbiota in the development and maintenance of gut homeostasis.
• The molecular mechanisms of neurotransmitter synthesis and release.
• The physiological and behavioral effects of artificial light at night on wildlife.
• The genetic basis of developmental disorders such as autism and ADHD.
• The evolution of host-parasite coevolution and adaptation.
• The ecological dynamics of plant-herbivore interactions.
• The role of microbiota in the regulation of metabolism and energy balance.
• The molecular mechanisms of membrane transport and signaling.
• The physiological and behavioral effects of habitat fragmentation on wildlife.
• The genetic basis of circadian rhythms and sleep disorders.
• The evolution of animal cognition and decision-making.
• The ecological and evolutionary dynamics of trophic cascades.
• The role of microbiota in the development and function of the respiratory system.
• The molecular mechanisms of epigenetic inheritance.
• The physiological and behavioral effects of endocrine disruptors on wildlife.
• The genetic basis of developmental plasticity and adaptation.
• The evolution of animal social learning and culture.
• The ecological dynamics of predator-prey interactions in aquatic systems.
• The role of microbiota in the regulation of host immunity and inflammation.
• The molecular mechanisms of RNA interference and gene silencing.
• The physiological and behavioral effects of climate change on migratory animals.
• The genetic basis of drug addiction and substance abuse disorders.
• The evolution of animal cooperation and conflict resolution.
• The ecological and evolutionary dynamics of niche construction.
• The role of microbiota in the regulation of host-microbe interactions.
• The molecular mechanisms of gene regulation by non-coding RNAs.
• The role of epigenetics in gene expression and regulation.
• The molecular mechanisms of DNA damage response and repair.
• The impact of environmental toxins on human health.
• The evolutionary origins of viruses and their impact on hosts.
• The genetics of aging and age-related diseases.
• The impact of ocean acidification on marine organisms.
• The molecular basis of cancer development and progression.
• The genetic basis of behavior in animals.
• The impact of environmental stressors on plant growth and productivity.
• The evolution of sex determination and sexual selection.
• The role of the immune system in host-microbe interactions.
• The molecular mechanisms of circadian rhythms and sleep.
• The impact of air pollution on respiratory health.
• The genetic basis of speciation and hybridization.
• The role of neurotransmitters in brain function and behavior.
• The ecological dynamics of microbial communities in soil.
• The impact of climate change on biodiversity and ecosystem services.
• The molecular mechanisms of viral entry, replication, and release.
• The genetics of plant domestication and diversification.
• The role of mitochondrial DNA in aging and disease.
• The impact of deforestation on ecosystem functioning.
• The molecular basis of drug addiction and treatment.
• The genetic basis of adaptation and evolution in response to environmental change.
• The role of gut-brain signaling in behavior and disease.
• The impact of noise pollution on wildlife populations.
• The genetic basis of plant morphology and development.
• The role of the microbiome in disease susceptibility and resistance.
• The ecological dynamics of plant-insect interactions.
• The impact of agricultural practices on soil health and biodiversity.
• The molecular mechanisms of gene regulation in development and disease.
• The genetic basis of complex traits in humans and animals.
• The role of cytokines in immune response and inflammation.
• The ecological dynamics of microbial communities in aquatic ecosystems.
• The impact of plastic waste on marine ecosystems.
• The molecular mechanisms of genome stability and repair.
• The genetics of rare and common genetic diseases.
• The role of the endocannabinoid system in health and disease.
• The ecological dynamics of competition and cooperation in populations.
• The impact of light pollution on wildlife behavior and ecology.
• The genetic basis of animal migration and navigation.
• The role of the microbiome in host metabolism and energy balance.
• The impact of climate change on agricultural productivity and food security.
• The molecular mechanisms of epigenetic inheritance and transmission.
• The genetics of human brain development and disorders.
• The role of pheromones in animal communication and behavior.
• The ecological dynamics of host-microbe-pathogen interactions.
• The effect of diet and nutrition on gut microbiome diversity and composition.
• The ecology and evolution of microbial interactions in the soil.
• The role of epigenetic modifications in cancer development and progression.
• The impact of climate change on marine biodiversity and ecosystem functioning.
• The molecular mechanisms of mitochondrial respiration and ATP synthesis.
• The role of non-coding RNAs in gene regulation and disease.
• The evolution and diversification of flowering plants.
• The effects of artificial light at night on animal behavior and physiology.
• The genetic basis of adaptation to extreme environments.
• The ecology and evolution of plant-microbe interactions.
• The physiological and behavioral effects of noise pollution on wildlife.
• The molecular mechanisms of DNA methylation and histone modification.
• The role of microbial communities in the cycling of nutrients in aquatic ecosystems.
• The evolution of animal color vision and perception.
• The ecological and evolutionary dynamics of mutualistic interactions.
• The impact of deforestation on soil fertility and carbon storage.
• The molecular mechanisms of viral replication and pathogenesis.
• The role of microorganisms in the biodegradation of plastics.
• The ecology and evolution of microbial communities in the human gut.
• The physiological and behavioral effects of climate change on birds.
• The impact of invasive species on native ecosystems.
• The genetic basis of developmental disorders and intellectual disabilities.
• The evolution of animal behavior and communication in response to anthropogenic change.
• The ecological dynamics of soil carbon sequestration and storage.
• The role of microbial communities in the decomposition of organic matter.
• The physiological and behavioral effects of air pollution on plants.
• The molecular mechanisms of cellular differentiation and tissue development.
• The ecology and evolution of plant-animal interactions.
• The genetic basis of resistance to herbicides and pesticides in crops.
• The impact of urbanization on bird diversity and distribution.
• The role of microorganisms in the cycling of carbon and nitrogen in soil.
• The ecological and evolutionary dynamics of invasive species interactions.
• The physiological and behavioral effects of climate change on reptiles and amphibians.
• The role of microbial communities in the degradation of petroleum hydrocarbons.
• The genetic basis of plant development and growth.
• The evolution of animal migration and dispersal.
• The impact of land use change on freshwater biodiversity.
• The molecular mechanisms of membrane transport and ion channels.
• The role of microorganisms in the cycling of sulfur and phosphorus in soil.
• The physiological and behavioral effects of ocean acidification on marine organisms.
• The genetic basis of behavior and personality traits in humans.
• The evolution of plant reproductive strategies and pollination systems.
• The ecological and evolutionary dynamics of predator-prey coevolution.
• The impact of environmental stressors on gene expression and epigenetics.
• The evolution of sexual reproduction and mating systems in plants.
• The role of microorganisms in bioremediation of contaminated sites.
• The physiological and behavioral effects of climate change on fish.
• The molecular mechanisms of chromatin remodeling and gene regulation.
• The genetic basis of adaptation to high altitude environments.
• The ecology and evolution of plant-insect interactions.
• The impact of pesticide use on insect biodiversity and ecosystem functioning.
• The role of microorganisms in nitrogen fixation and cycling.
• The genetic basis of neurodegenerative diseases and cognitive decline.
• The evolution of social behavior and cooperation in animals.
• The ecological and evolutionary dynamics of plant invasions.
• The physiological and behavioral effects of noise pollution on humans.
• The molecular mechanisms of RNA splicing and alternative splicing.
• The role of microorganisms in biogeochemical cycling of trace elements.
• The genetic basis of adaptation to extreme temperatures.
• The ecology and evolution of microbial communities in soil and water.
• The impact of climate change on insect phenology and distribution.
• The molecular mechanisms of protein folding and misfolding.
• The role of microorganisms in biodegradation of environmental pollutants.
• The evolution of animal cognition and intelligence.
• The ecological and evolutionary dynamics of predator-prey interactions.
• The impact of anthropogenic noise on marine mammals.
• The role of microorganisms in biofilm formation and quorum sensing.
• The genetic basis of speciation and hybridization in plants.
• The evolution of parental care and offspring development in animals.
• The ecological and evolutionary dynamics of food web interactions.
• The physiological and behavioral effects of air pollution on human health.
• The molecular mechanisms of transcriptional regulation and gene expression.
• The role of microorganisms in plant growth promotion and disease suppression.
• The genetic basis of adaptation to drought stress in crops.
• The ecology and evolution of microbial interactions in the ocean.
• The impact of land use change on soil erosion and nutrient cycling.
• The molecular mechanisms of autophagy and programmed cell death.
• The role of microorganisms in biodegradation of pharmaceuticals.
• The genetic basis of immune system variation and disease susceptibility.
• The evolution of animal social networks and communication systems.
• The ecological and evolutionary dynamics of biodiversity loss.
• The physiological and behavioral effects of light pollution on nocturnal animals.
• The molecular mechanisms of DNA repair and genome stability.
• The role of microorganisms in the production of biofuels and bioplastics.
• The genetic basis of adaptation to salinity stress in plants.
• The ecology and evolution of microbial symbioses with plants and animals.
• The impact of climate change on plant-pollinator interactions.
• The molecular mechanisms of cellular senescence and aging.
• The role of microorganisms in biodegradation of synthetic organic compounds.
• The genetic basis of variation in complex traits in humans.
• The evolution of animal social behavior and cultural transmission
• The genetic basis of cancer development and progression.
• The role of microorganisms in the gut microbiome and human health.
• The genetic basis of phenotypic plasticity and adaptation in plants.
• The evolution of animal migration and navigation.
• The ecological and evolutionary dynamics of community assembly.
• The physiological and behavioral effects of light and dark cycles on circadian rhythms.
• The molecular mechanisms of protein synthesis and degradation.
• The role of microorganisms in nitrogen and carbon cycling in aquatic ecosystems.
• The genetic basis of sex determination and differentiation in animals.
• The ecology and evolution of predator-prey coevolution.
• The impact of anthropogenic activities on marine biodiversity and ecosystems.
• The role of microorganisms in bioleaching and biomining of metals.
• The genetic basis of inherited disorders and genetic diseases.
• The evolution of animal social behavior and communication systems.
• The ecological and evolutionary dynamics of competition and coexistence.
• The physiological and behavioral effects of endocrine disruptors on human health.
• The molecular mechanisms of cell division and mitosis.
• The role of microorganisms in biodegradation of plastics and synthetic materials.
• The genetic basis of epigenetic inheritance and regulation.
• The ecology and evolution of mutualistic symbioses in plants and animals.
• The impact of habitat fragmentation on species diversity and ecosystem functioning.
• The role of microorganisms in bioremediation of oil spills.
• The genetic basis of drug resistance in pathogens and cancer cells.
• The evolution of animal personality and individual variation.
• The ecological and evolutionary dynamics of biotic interactions in freshwater ecosystems.
• The physiological and behavioral effects of artificial sweeteners on human health.
• The molecular mechanisms of intracellular trafficking and secretion.
• The role of microorganisms in biocontrol of plant pathogens and pests.
• The genetic basis of hybridization and introgression in animals and plants.
• The ecology and evolution of plant-pollinator mutualisms.
• The impact of climate change on marine ecosystems and fisheries.
• The molecular mechanisms of genome editing and gene therapy.
• The role of microorganisms in biogas production and carbon capture.
• The genetic basis of developmental disorders and birth defects.
• The evolution of animal coloration and camouflage.
• The ecological and evolutionary dynamics of invasive species.
• The physiological and behavioral effects of air pollution on wildlife.
• The molecular mechanisms of signal transduction and cell signaling.
• The role of microorganisms in biodegradation of pharmaceuticals and personal care products.
• The genetic basis of reproductive isolation and speciation.
• The ecology and evolution of microbial interactions with plants and insects.
• The impact of climate change on bird migration and breeding patterns.
• The molecular mechanisms of protein-protein interactions and protein complexes.
• The role of microorganisms in bioremediation of heavy metals.
• The evolution of animal cognition and learning.
• The ecological and evolutionary dynamics of biodiversity hotspots.
• The impact of ocean acidification on marine ecosystems.
• The genetics of complex diseases and personalized medicine.
• The evolution of plant defense mechanisms against herbivores.
• The role of microorganisms in soil carbon sequestration.
• The physiological and behavioral effects of light on plant growth and development.
• The molecular mechanisms of cancer metastasis and invasion.
• The ecology and evolution of microbial communities in the human body.
• The impact of climate change on migratory bird populations.

About the author

Muhammad Hassan

Researcher, Academic Writer, Web developer

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Top 100 biology research topics for high school and college.

Writing a biology essay may not sound like a very difficult thing to do. In fact, most students really like this subject. The problem is not that you can’t write a good paper on a topic in biology. The problem is with finding excellent biology research topics. Now, you may be wondering why you would want to invest so much time into finding great biology research paper topics. After all, what you write in the essay matters more than the topic, right? Wrong! We are here to tell you that professors really appreciate interesting and unique topics.

And it makes a lot of sense, if you think about it. If you simply pick one of the most popular biology research topics, you will never be able to pique the interest of your teacher. He has read dozens, if not hundreds, or papers on that exact same topic. What you want to do is come up with interesting biology research topics. You want to find topics that none of your classmates are thinking of writing an academic paper about. You will shortly see why this is important. And we will also give you 100 biology topics for research projects that you can use for free – right now!

Biology Research Paper Topics Really Are Important!

It doesn’t matter what area of biology you need to write about. This information applies to everything from zoology and botany to anatomy. The reality is that your professor will really appreciate good topics. And you can rest assured that he or she knows how to spot them. The moment the professor starts to read your paper, he or she will immediately realize that you really did your best to find an excellent topic. And if you write a good introduction paragraph (which contains a captivating thesis statement as well), you are in the best position to earn bonus points.

You may not be aware of it, but teachers are willing to treat great papers with more leniency. This means that you will not get penalized for minor mistakes if you come up with a great topic. In other words, you will get a better grade on your papers if you manage to come up with good research topics for biology. This is a fact and it is based on thousands of pieces of feedback from our readers.

How Do You Choose Good Biology Research Topics?

Choosing research topics for biology can be a daunting task. Frankly, the research paper topics biology students are looking for are not easy to come by. The first thing you want to avoid is going to the first website that pops up in Google and getting your ideas from there. Most of your peers will do the same. Also, avoid topics that are extremely simple. You will simply not have enough ideas to write about. Of course, you should avoid overly complex topics because finding information about them may be extremely difficult.

The best way to find a good topic, in our opinion, is to get in touch with an academic writing company. You will get access to a professional writer who knows exactly what professors are looking for. A writer will quickly give you an amazing research topic in biology.

Eloquent Examples of Popular Biology Research Topics

To make things as simple as possible for you, we’ve put together a list of biology research project ideas. You will find 100 topics on various subjects below. Of course, you can use any of our topics for free. However, keep in mind that even though we are doing our best to maintain this list fresh, other students will find it as well. If you need new topics for your next biology essay, we recommend you to get in touch with us. We monitor our email address, so we can help you right away. Also, you can buy a research paper from our service.

Biology Research Topics for High School

Are you looking for biology research topics for high school? These are relatively simple when compared to college-level topics. Here are a couple of topic ideas that high school students will surely appreciate:

• Identifying Three Dead Branches of Evolution.
• What Is Sleep?
• How Does Physical Exercise Affect the Metabolism?
• A Behavioral Study of Birds.
• How Does Music Affect Your Brain?
• Climate Change and Biodiversity.
• Are Bees Really Becoming Extinct?
• Rainforest Extinction Is Dangerous.
• The Benefits of Organic Farming.
• Can the Brain Repair Itself?
• The Effect of Bacteria on Depression.
• How Do Sea Animals Camouflage?

Research Topics in Biology for Undergraduates

Research topics in biology for undergraduates are more complex than high school or college topics. Our researchers did their best to find topics that are relatively complex. However, each one of the following topics has plenty of information about it online:

• What Is the Mechanism of Metastasis in Cancer Patients?
• How Do Tumor Suppressor Genes Appear?
• How Can We Destroy Cancer Cells Without Damaging Other Cells?
• The Benefits of Gene Therapy.
• Analyzing the Huntington’s Disease (the HTT Gene).
• How Does the down Syndrome (Trisomy of 21st Chromosome) Appear?
• Analyzing the Brain Activity During an Epileptic Seizure.
• How Are Our Memories Formed and Preserved?
• The Effect of Probiotics on Infections.
• Analyzing Primate Language.
• Analyzing Primate Cognitive Functions.
• The Link Between Darwin’s Theory and Biology.

Biology Research Topics for College Students

Biology research topics for college students are of moderate difficulty. They are easier than undergrad topics and more complex than high school topics. While compiling this list, we made sure you have more than enough information online to write the paper quickly:

• Using DNA Technology in the Field of Medical Genetics.
• The Effect of Drinking on Embryonic Development.
• How Are Genes Mapped and Cloned?
• Explain What Genetic Polymorphism Is.
• What Is a Hereditary Disease?
• The Effect of Drugs on Embryonic Development.
• Describing Oligogenic Diseases (like Hirschsprung Disease)
• What Is the Mendelian Inheritance?
• How Transcriptomics and Proteomics Changed Modern Medicine.
• The Risk Factors of Infertility Explained.
• How Does Aging Effect Infertility?
• What Do Ash Elements Do in a Plant?
• Explaining the Pigments in a Plant Cell.
• How Is Photosynthesis Done?
• The Role of Fats in Plant Cells.
• The Effect of Smoking on Embryonic Development.

Cell Biology Research Topics

Some of the best biology topics are cell biology research topics. The scientific community is constantly making progress in this area, so there is always something new to write about. Here are some of the best examples:

• What Is Regenerative Medicine?
• A Closer Look at Tissue Engineering.
• Discuss the Future of Regenerative Medicine.
• Analyzing Therapeutic Cloning.
• The Pros and Cons of Creating Artificial Organs.
• How Do Cell Age?
• Can We Reverse Cell Aging?
• Advances in Cell Therapy.
• What Is Cell Adhesion?
• Explaining Cell Division.
• What Is Cellular Metabolism?
• Describe Active and Passive Transport in Cells.
• What Are Cell Plastids?

Evolutionary Biology Research Paper Topics

If you want something more complex, you can try your hand at writing on evolutionary biology research paper topics. As with all our topics, you will be able to find a lot of ideas and information online. Here are our picks:

• Where Did Plants Come From? (The Evolutionary Theory)
• Explaining the Host-parasite Coevolution.
• How Did Parasites Evolve over Time?
• What Is Natural Selection and How Does It Work?
• Explain Sexual Selection.
• Explain Sexual Conflict.
• How Did Our Immune Systems Evolve?
• How Do New Species Appear in the Wild?
• The Evolution of Cell Respiration.
• What Is the Hippo Pathway? (Developmental Biology)

Various Topics

Antibiotics resistance, agriculture and cloning are hot subjects nowadays. Your professor will surely be interested to learn more about biology research topics. Here is a mix of topic ideas from our established community of academic writers:

• The Problem of Using Antibiotics on Large Scale.
• Examining the Effects of Salt on Plants.
• What Is DNA Technology?
• The Effects of GMOs on the Human Body.
• How Is the Quality of Antibiotics Controlled?
• How Are GMO Food Crops Created?
• The Effect of Veterinary Antibiotics on Humans.
• The Allergic Reactions to Specific Antibiotics.
• A Look at How Penicillin Works in the Human Body.
• How Are Antibiotics Obtained?
• What Are Natural Biochemicals with Pest-repellent Properties?
• The 3 Most Toxic Effects of Antibiotics
• How the Human Body Develops Resistance to Antibiotics.
• The Impact of Biology on the Us Agriculture.
• What Is the Green Revolution?
• Analyzing the Minerals in the Plant Cell.
• Analyzing Muscle Development and Regeneration
• The Uses of Cancer Stem Cells.

Marine Biology Research Topics

There is a lot of talk about global warming, about microplastics in our oceans, and about endangered marine species. This means that marine biology research topics are a very hot topic today. Here are some of our best ideas:

• Can GMO Organisms Break down Oil after Maritime Accidents?
• Pollution-absorbing Bio-films.
• Microbes That Can Absorb Toxic Compounds in the Water.
• Can We Really Use Bioluminescence?
• How Is Bio-diesel Created?
• Analyzing the Coral Reef Biology.
• Why Is the Lobster Population Dwindling?
• The Effect of Mass Fishing on the World’s Oceans.
• Global Warming and Its Effect on Marine Microorganisms.

Molecular Biology Research Topics

Writing about molecular biology research topics is not easy. However, it’s a foolproof way to get a top grade. Your professor will really appreciate your willingness to write an essay about a complex topic. Just make sure you know what you are talking about. Below you can find some of the best topics:

• How Is Insulin Produced?
• How Is the Growth Hormone Produced?
• Analyzing the Repropagation of Translation.
• What Is DNA-telomerase?
• The Process of Sequencing Nucleotides in DNA.
• What Is Telomerase?
• The Link Between Telomerase and Cancer.
• The Link Between Telomerase and Aging.
• How Does DNA Forensics Work?
• Describe the Process of Protein Metabolism.

There is no such thing as easy biology research topics. When the topic is too simple, you end up getting penalized. You can’t write 500 words about it without straying away from the subject. Also, no matter how interesting the topic may be, you should make sure that the essay is written perfectly. This means that not even interesting biology research topics can save you from a bad grade if you fail to follow all applicable academic writing standards.

Find it hard to cope with your college paper? Great news! Use promo “ mypaper20 ” and enjoy 20% discount on a biology writing assignment from our profs!

Biology Research Projects for High School Students: 20 Ideas To Try This Summer

By János Perczel

Co-founder of Polygence, PhD from MIT

16 minute read

Biology and biomedical research are two of the most popular academic disciplines among high schoolers. If you’re someone who’s interested in those fields and you’re looking for research opportunities this summer, you’ve come to the right place! With the study of biology, not only can you gain a better understanding of the natural world, but your research can have practical applications in fields like medicine, agriculture, and environmental science. Whether you’re just starting out in your exploration of biology, have taken a biology class in school, or you’re looking to do some advanced research to submit to your state’s science fair , we have level-appropriate ideas for you!

With a variety of topics like cancer treatment, genetics, neurodegenerative diseases, and marine life, we’ve got you covered. Here is a curated list of 20 different research project ideas to get those creative juices flowing. If you’re hungry for more, head over to our comprehensive Project Ideas database here and browse over 2800 more ideas!  

Research YOUR fave areas of Biology and Medicine

Polygence pairs you with an expert mentor in to create a passion project around biology and medicine. Together, you work to create a high quality research project that is uniquely your own. We also offer options to explore multiple topics, or to showcase your final product!

Human Body Project Ideas

Rate of cognitive decline in different elevations.

Oxygen partial pressure decreases with altitude, challenging blood oxygenation which may affect brain function. If you’ve ever felt some altitude sickness, then this is exactly what’s happening. This is because the atmospheric pressure decreases at higher elevations, leading to a decrease in the partial pressures of the gasses in the air, including oxygen. And of course, oxygen is needed for us to function. What is the effect on brain health/ cognition in sudden increased elevation: say, climbing Mount Everest? Does chronic exposure to high elevations increase the likelihood of dementia? In this project, a meta-analysis of published works examining the effects of altitude on cognition would be conducted.

Idea by mentor Alyssa

Building a Blood Vessel

Use online graphics to illustrate how a blood vessel forms. Blood vessels are structures that carry blood and are responsible for transporting nutrients and oxygen throughout the body. There are three main types of blood vessels: arteries, veins, and capillaries. For this project, complete a literature search to understand what is known about blood vessel growth. Then, utilize this information to generate a graphic with no words to demonstrate how the vasculature (network of blood vessels) forms. The goal of this project is to explain science without using text and therefore make it more available to a larger community.

Idea by mentor Natalie

Examining the bacterial profile of various households

As of late, bacterial microbiomes have been a huge and interesting topic in the field of bacteriology as they play an important role in human health. Bacterial microbiomes are communities of bacteria that live on or outside organisms. They’re found in various parts of the human body, and help us to digest food and regulate our immune system. In this project, you will seek to understand how skin microbiomes can differ between different  individuals of different households. This project will require making different bacterial media that can be made at home selecting for various microorganisms. If you’re new to preparing bacterial media, check out this resource here!

Idea by mentor Hamilton

Regulation of Circadian Clocks

Sleep is known to be governed by two distinct processes: a circadian clock that aligns sleep and wakefulness to the solar day and the sleep homeostat that encodes for sleep debt as a compensatory mechanism against sleep loss. You’ve most likely heard about circadian rhythm and our body’s internal clock, and circadian regulation of sleep is a fundamental process that allows animals to anticipate sleepiness or wakefulness consistently every day. These mechanisms can be regulated in multiple ways: at the gene, protein, gene, and clock neuronal level. In this project, we will focus on 1) how to efficiently digest primary and review articles to compile and condense information, 2) investigate how circadian clocks are regulated at these different genetic levels, and 3) try to effectively summarize the information we've gathered. We can present this information in a variety of ways, and what the final product looks like is up to you.

Idea by mentor Oscar

The Biology of Aging

Aging is the number one risk factor for a variety of diseases including cancer, neurodegenerative disease, and loss of hearing/sight. We are only now beginning to truly understand the process of aging and have even started to uncover ways that we could stop, or potentially reverse, the effects of aging. What are the hallmarks/signs of aging? How do researchers study 'aging'? How does human lifespan and aging compare to the rest of the animal kingdom? Is it possible to stop or reverse the effects of aging? What advancements are being made related to this? We could explore these questions or brainstorm others you might have about the biology of aging.

Idea by mentor Emily

Animals, Plants, and Nature Project Ideas

How genetically engineered mosquitoes are reducing rates of vector-borne diseases such as zika.

Many countries are already releasing millions of genetically engineered mosquitoes into the wild every week. These mosquitoes have been modified to reduce their ability to transmit disease-causing pathogens like dengue fever, Zika, and malaria, and are sent into the wild to mate with disease-carrying mosquitoes. However, this is still controversial as some people are concerned about the unintended consequences on the environment. What could be the potential pros and cons for this? The project will mainly focus on doing meta analysis of articles and watching informative videos to understand how/why genetically engineered mosquitoes can be used to reduce rates of different diseases. Students will have the chance to use critical thinking and do in-depth research on genetic engineering techniques, how scientists determine breeding rates and number of insects released, and epidemiology of different bloodborne diseases.

Idea by mentor Vanessa

Efficacy of Marine Protected Areas

Marine protected areas (MPAs) are areas of ocean or coastal waters that are set aside for the conservation and sustainable use of marine resources. These areas are established by governments, NGOs, or other organizations, and they can take different forms, from fully protected "no-take" zones to areas with regulated fishing or other activities. Marine protected areas have the potential to guide sustainable resource management and protect biodiversity, but have a host of reasons for why they are not currently effective. Explore reasons for why MPAs may not be effective. Then develop a framework for mapping, modeling, and implementing an effective Marine Protected Area.

Bioinspiration: Do animals hold the answers?

Can the toxins produced by frogs help us fight antibiotic resistant bacteria strains? How can understanding how lizards and newts regrow their limbs help us improve wound treatment? Why do tilapia skins help with burns? Discover the role of animals in the development of modern medicine as well as its potential. Are there any ethical concerns with these developments and findings? If so, what are they and do they matter? Share your findings in a research proposal, article, or presentation.

Idea by mentor Cheyenne

How Climate Change Can Affect Future Distributions of Rare Species

Climate change, such as global warming and longer drought, can threaten the existence of some of the rarest plants on earth. It is important to understand how future suitable habitats will change for these rare species so that we can target our conservation efforts in specific areas. In this project, you will identify a rare species that you like (it can be animals, plants, or fungi!), and gather the data online on its current occurrences. Then you will learn how to perform species distribution modeling to map its current and future suitable habitat areas. To get you started on learning species distribution modeling, check out this Youtube resource here. The changes in the amount or location of future suitable habitats can significantly affect the destiny of a rare species. By doing this project, you will not only learn skills in data analyses but also become the best ambassador for this rare species that you love. 

Idea by mentor Yingtong

A Reef’s Best Frenemies

Coral reefs are in global decline. A primary cause of this is "coral bleaching" which results in the white reefs we often see in the news. Coral bleaching is actually the breakdown in the partnership between the coral animal and tiny, symbiotic algae that live within its cells. Corals and algae have a variety of thermal tolerances which are likely decided by genetic and environmental factors. However, despite how important this relationship is, it's currently very poorly understood. This project would review existing literature on the symbiotic partnernship and try to identify factors that predict bleaching and thermal resilience.

Idea by mentor Carly

Dive in to BioMed NOW!

Register to get paired with one of our expert mentors and to get started on exploring your passions today! You have agency in setting up your schedule for this research. Dive in now!

Diseases and Treatments Project Ideas

The understanding of a new and upcoming treatment: immunotherapy.

Immunotherapies have been growing in the past few years as alternative treatments for many types of cancer. These treatments work by boosting the patient's immune system to fight the disease, however it is not always effective. There are many types of immunotherapies with various nuances, but they all work to attack specific cells that are causing the disease. For this project, pick one of a few types of immunotherapy and deeply understand the mechanism of action and what is the current effectiveness against the cancer it treats.

Idea by mentor Hannah

Exploring The Cancer Genome Atlas data 

There has been an explosion of publicly available data for cancer. The Cancer Genome Atlas was a research program with the purpose of creating a comprehensive catalog of genomic and molecular information about different types of cancer, with the aim of improving our understanding of the disease and developing new treatments. The dataset has been used to identify new cancer subtypes, develop diagnostic tests, and discover potential targets for new cancer therapies. Explore the implications and impact of The Cancer Genome Atlas data, and why it’s become so important.

Idea by mentor Hersh

Systematic Review and Meta-Analysis of Physiological Benefits of Fasting-induced Autophagy

Autophagy, meaning "self-eating", is a cellular process where damaged or unwanted components are disposed. Autophagy has been linked to various diseased pathologies, including cancer and heart disease. Fasting or specific dietary lifestyles may induce levels of autophagy in the human body. In this project, we will perform and systematic review and meta-analysis of fasting or diet-induced autophagy and its benefits on the body. You will gain skills in 1) searching and reviewing primary literature, 2) computational skills for performing data analysis (R language), and 3) writing your scientific findings.

Idea by mentor Jose 

The Amyloid Hypothesis: Sifting through the controversy

For many years, scientists have thought that amyloid beta was the protein responsible for a patient developing Alzheimer's Disease symptoms. This "Amyloid Hypothesis" is now being questioned in light of current clinical data. Recently, drugs have been developed that reduce amyloid beta in patients. Surprisingly, the drugs worked in reducing amyloid beta, but it did not result in the slowing of disease pathology. Does this mean that the amyloid hypothesis is incorrect? Is amyloid beta less important in the progression of disease then what we once thought? This research project aims to explore the issues with the amyloid hypothesis and to assess where we stand in our understanding of amyloid beta's contribution to Alzheimer’s.

Idea by mentor Patrick

How do vaccines work?

During the COVID pandemic, vaccines have been all over the news! But how do they actually work? What’s the science behind them? Through this project, you will explore how vaccines work and the history of science behind vaccine development. While the final product of the projectwill be up to you, the ultimate goal of this project is for you to be a true public health advocate for vaccines and to be able to communicate why vaccines are so important in a way that the general public can understand.

Idea by mentor Helen

Sleep Disruption Profiles in Various Mouse Models of Alzheimer’s

Alzheimer's disease (AD) has been studied for decades but we are no closer to understanding the mechanisms of the disease. Because of the vast number of researchers studying AD, there are numerous models used to study the disease. All these models have different sleep profiles, phenotypes, disease onsets, sex differences etc. Therefore, in this project we will compile a document based on extensive literature review about the various models there are. We will focus on sleep profiles in these animals with an emphasis on male and female differences. This information is valuable because it is important to know which model is best to use to answer your scientific questions and there is a lot of criticism (by other scientists) that can be brought on by the model chosen so you need to be able to justify your choice. This project will also introduce you to the world of AD research and some of the gaps in knowledge in the field.

Idea by mentor Shenee

Rethinking The Treatment Of Neurodegenerative Diseases

Neurodegenerative diseases affect millions of people worldwide. They are conditions that affect the nervous system, particularly the brain and spinal cord, and examples include Alzheimer’s and Parkinson’s. While billions of dollars have been spent trying to find treatments for the disease, very few drugs and therapies have had a meaningful impact on slowing down disease progression. This is often because by the time someone is diagnosed with a disease, it has progressed too far for a treatment to have a substantial effect. Some recent approaches to treatment have turned to looking for early indications of the disease (termed "biomarkers") that can occur before the onset of symptoms. By diagnosing disease and beginning treatment before symptoms arise, these treatments could have a more profound effect in slowing down the progression of disease. Students could review the recent progress being made on identifying biomarkers for neurodegenerative diseases, and either write a paper or even record a podcast on their findings!

Idea by mentor David

Genetics Project Ideas

Height and genetics: nature or nurture.

How much do your genes determine your height? How much do nutrition and environmental factors play a role? What gene variants are implicated in height differences and what is the role of epigenetics? Epigenetics is the study of heritable changes in gene expression or cellular phenotype that occur without changes to the underlying DNA sequence. These changes can be influenced by diet and lifestyle. We will access and analyze an open dataset on twins to estimate the correlation between monozygotic twins (who have the exact same DNA) and height. You will learn to use R to open a dataset, analyze data with statistical methods such the student’s t-test, and display your data as graphs and charts. Finally, you will learn how to make a research presentation on height and genetics, describe the research methods, and present the data in a compelling and thorough way.

Idea by mentor Adeoluwa

The World of Personalized Medicine

Similar to our fingerprints, our genetic code is also unique to each individual person. Our genetic code is what determines our hair color, height, eye color, skin tone...just about everything! For those that develop diseases such as cancer, their genetic code found inside the malignant cells that comprise a tumor may also be unique to them or to certain groups of people with similar mutations (the drivers of disease). So why is it that we treat each person the same way even though the genetic drivers of that disease may be disparate? The world of Personalized Medicine is new and exciting and looks to circumvent this problem. Personalized Medicine (also known as precision medicine) uses the genetic code of a patients disease to guide treatment options that prove to be highly efficacious. Together, lets write a review on a disease of your choice that could benefit from Personalized Medicine based on current literature and research.

Idea by mentor Somer

General Biology Project Ideas

Teach a biology concept two ways: to your fellow students and to the general public.

One of the best ways to learn is to teach. Choose a biological concept that interests you and prepare a lesson and or demo on it. The format should be a video recording of yourself teaching (a la Khan Academy or a Zoom class), but the other details are up to you. Consider incorporating a demonstration (e.g. how can you use items from your kitchen to illustrate properties of mixtures?) or animation (e.g. to illustrate molecular motion). Also consider how you will check that your students understand the concept(s) and/or skill(s) you have taught them. Prepare and record two versions of your lesson: one intended for your peers and one for the general public. How will the versions differ to reflect these different audiences? You will learn what it's like to teach, gain a much greater understanding of your chosen concept(s)/skill(s), and learn how to communicate science to different audiences.

Idea by mentor Alexa

Once you’ve picked a project idea, check out some of our resources to help you progress with your project! Whether you’re stuck on how to cite sources , how to come up with a great thesis statement , or how to showcase your work once it’s finished , we’ve created blog posts to help you out. If you’re interested in doing one of the biology research projects with the help of an amazing mentor at Polygence, apply now ! If you would like some help with coming up with your own idea, book a complimentary consultation call with our admissions team here ! For more biology and science research information, check out our comprehensive list of research opportunities for high school students .

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List of Biology Research Topics

Best Biology Research Topics For University Students

What is biology research paper, how to write interesting biology research paper topics, list of action research topics in biology, developmental research topics in biology for undergraduates, biology research topics for high school, biological anthropology research topics, biology education research topics, human biology eesearch topics, computational biology presentation ideas, interesting biology research topics, marine biology research proposal topics, research topics in mathematical biology, forensic biology research topics for college students, plant biology topics to write about, how can we help you to find biology research proposal topics.

Hello, learners! Hope you are doing well! Today, we get back to another most demanding topic on biology research papers. It has been seen so far that students often topic Students often complications while writing their academic research-based assignments. The reasons might be many, but the difficulties are the same for almost every student. Writing a biology research paper, first, you have to find some good biology research topics that aim to highlights providing helpful information on specific biology research papers. Writing research assignments requires good writing skills, a lot of time, and knowledge. Second, you have to be very precise with your research findings and analysis that presents your biological explanations and theories. We have analyzed that students search for good topics for biology research papers online and find it very difficult to choose the best. Therefore, we are here with a long list of biology research topics for students, which every student can use to write their biology research papers.

A biology research paper is an expanded form of essay that students are required to write at University. This research paper aims to showcase the interpretation, data collection or evaluation, or arguments that students learn throughout their academic tenures. Your biological research topics highlight your understanding and knowledge of the subject. A research paper includes surveying a field of your expertise, researching methods, and finding the best possible response to information in that field.

Writing research topics for biology, you must select a topic of your interests. You are the only one who is going to be working on that topic, so choose a topic that amazes you. Brainstorm your ideas and your class discussions and reading assignments; did anything spark your curiosity? Choose a facet of the topic that makes you attentive and your audience. Ask for suggestions from your professors and try to fulfill those expectations for the assignment. However, you can choose traditional biology subfields like plant and animal biology, ecology, or popular biology research topics related to humans: neurobiology, recent discoveries on diseases, etc.

Here is a list of biology research topics for college students that students can consider as a guide:

• The action of viruses on red blood cells
• The action of dynamic property of the genotype; environment interaction propositions for biotechnology
• Conservation biology in action
• An incorporative biological approach for investigation of drug action in models of human vascular inflammation
• Biological cohesion as the architect of bed movement under wave action
• illuminating drug mechanism and target biology of action across human cell-based model systems
• Adults' and children models for expecting teleological action: the development of a biology-based model

These examples of biology research topics are perfect for learners and researchers who want to leave a lasting impression on the reader:

• The role of the spliceosome protein PRPF8 in embryonic development
• long noncoding RNA control of drosophila hox gene expression
• The role of gene regulation in stem cell biology & brain development
• To discover novel proteins regulating gene expression development of a reverse chip-sequencing (Rchips) technology Advancing evolutionary developmental biology
• Bioimaging in developmental biology
• Developmental biology: mathematical modeling of development
• Define neurological disorders and early life perturbations in later life

Writing a biology research paper requires high-level responses on a variety of interesting biological topics. Check these out:

• Is it moral to trial cosmetic products on animals?
• What are the troubling impacts of invasive plants on earth?
• What is the significance of genomic fingerprinting?
• Explain the function and implications of biology in daily life.
• Explain the hypothesis and observations on animal cloning.
• Does Biochemical diagnostics an exhaustion method?
• Explain the effects of cellular communication in humans.
• Does the administration permit genetically engineered groceries?
• Define cloning of organs and tissues.

Listed below are undergraduate research ideas biology for students: have a look:

• Understanding racism in physical (biological) anthropology
• Power analysis in biological anthropology
• Are careers in biological anthropology sustainable?
• Geostatistics and spatial analysis in biological anthropology
• Morphometrics and biological anthropology in the postgenomic age
• Continuity and change in biocultural anthropology

The following sample of biology research topics for students that do not have the time to conduct in-depth research:

• Effects of conservation biology education: an approach toward nature
• Surging interest in biology education reform: how scientists play a crucial role?
• Classroom VS outdoor biology education: Identification of digital dichotomous key
• Molecular biology and Biochemistry education in a transforming academy and a molecular world
• Augmenting student's memory for learning: designing a contextual awareness capture system for biology education

Here are several biology research projects for college students concerning human biology:

• Human biology: an evolutionary and biocultural perspective
• Expanded immunotherapy, regenerative medicine, and biotechnology for potential stem cells.
• Single-cell biology of hematopoietic stem- and aging and progenitor cells in blood cancer
• Systematic and quantitative characterization of viral-host interaction for rational therapeutic and vaccine designs
• Applying the community partnership method to human biology research
• Engineering human tissue in vitro: description, development, and application.
• Microbiome analysis for human biology applications.

Here's your cart that contains a list of good research topics for biology:

• Parallel and evolutionary approaches to computational biology
• Models for collaborations and computational biology
• Define deep learning and Kernel methods: Computational biology perspective
• To understand neurodevelopmental disorders using CRISPR single-cell genomic screens
• Special issue: high-performance computational biology
• From genetics to cellular function, the use of computational biology
• Pragmatic computational biology: biological systems explanation and sequence analysis
• Computational biology of RNA interactions

Need interesting biology research topics? Let's have a look at below:

• Abortion and society: Why is this a controversial topic in most countries?
• The relationship between genetics and obesity.
• Epidemiology and coronavirus
• Does the covid-19 pandemic affect medical funding?
• Fast food factory danger activity and outcomes
• Do the techniques of human cloning can change medicine?
• The trend of DNA-modified organisms
• The reason for environmental changes
• Genetics, biology, and race: understanding human difference

This is the list of biology research project topics, will help you:

• In silico techniques used in marine biology research: an overview
• Recent innovations in marine biology
• Evolutionary aspects of marine biology
• From marine biology to biological oceanography
• Automated image processing in marine biology
• Developing marine education tools to promote ocean sustainability
• Bioaccumulation and synergistic effects of chronic pesticide pollution on aquatic organisms - impact on the community structure.

These good biology research topics cover the most interesting ideas in this growing area of science.

• What is contemporary historiography in the context of mathematical biology?
• Measuring cancer evolution in an altering tumor microenvironment
• Mathematical biology, social science and nonlinear dynamics,
• Some problems of mathematical biology
• Mathematical biology models of Parkinson's disease
• Learnings in mathematical biology: population and communities and cellular behavior and the development of the pattern.
• An integral equation comes up from a setback in mathematical biology.

This is a list of the research paper topics biology will undoubtedly capture your audience's attention:

• Evaluation of RNA stability to determine the age of body fluid stains in forensic biology
• Evaluating forensic DNA evidence: connecting the dots
• Conventional technologies in forensic science
• From a forensic perspective, insects as vectors of DNA
• A direct polymerase chain reaction of RNA and DNA for forensic purposes
• Forensic presumption of biogeographical ancestry from genotype

If you are looking for assignment help on biology topics , these ideas will meet most requirements without causing too much stress:

• Developing yield stability in wheat: Latest tools for analyzing and understanding
• Integration of development, photosynthesis, and anxiety as a prospect for plant biology
• understanding Ralstonia solanacearum plant pathogen evolution in environmental reservoirs
• Genetic interactions and novel genes that regulate lignin biosynthesis and straw quality in barley
• Investigating the biology and significance of microbial symbiosis in the plant pest, empoasca decipiens.
• Stress responses in crops and sustainable production of biomass and chemicals
• Plant and crop fertility: the impact and evolution of gene control networks
• Applications of genomics in plant biology
• Examination of a novel regulator of plant yield and health in plants

Still confuses? Are you looking for an expert who can give you the best Biology research paper topics? Then choose Australian assignment help from us; our experts will assist you in climbing the stepladder of victory. We have a team of Ph.D. experts and biology researchers who have years of expertise in writing flawless biology assignments. They will aid you in solving your complex research-based tasks and provide you good topics for biology research papers according to the specified academic guidelines. Let's see how our experts can help you:

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Nick is a multi-faceted individual with diverse interests. I love teaching young students through coaching or writing who always gathered praise for a sharp calculative mind. I own a positive outlook towards life and also give motivational speeches for young kids and college students.

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Department of Biological Sciences

Examples of Undergraduate Research Projects

Fall 2021 projects, previous projects.

• Foundations
• Write Paper

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• Experiments
• Anthropology
• Self-Esteem
• Social Anxiety

Biology research have provided great insights to the field and to the society by understanding the relationship between living organisms and nature.

This article is a part of the guide:

• Law Of Segregation
• Darwin’s Finches
• Transforming Principle
• Red Queen Hypothesis
• Industrial Melanism

Browse Full Outline

• 1 Biology Experiments
• 2 Law Of Segregation
• 3 Darwin’s Finches
• 4 Industrial Melanism
• 5 Red Queen Hypothesis
• 6 Transforming Principle

Here are some examples of biology research and discoveries which was important to biology as a branch.

Many of the examples are from evolutionary biology, but we are planning to add more biology experiments later on.

Biology Experiments and Discoveries

Law Of Segregation - The Mendel Pea Plant Experiment

Mendel noticed that certain characteristics appeared to be passed on from parents to offspring, in many species, and wondered why this was so. He tested his ideas, using pea plants.

Darwin's Finches - How the Natural Selection Was Discovered

Darwin brought back many samples from the Galapagos, and thought that the finches found across the different islands making up the group, were all different species. Then he made a remarkable discovery.

Industrial Melanism - How Human Contamination Evolved the Peppered Moth

The industrial revolution across Europe and North America, and the burning of coal, led to every surface, in certain areas, being covered with black soot. So animals evolved to get camouflage from the contamination.

Red Queen Hypothesis - The Evolutionary Arms Race between Prey and Predator

The basis for the entire theory is down to 'the evolutionary arms race', where prey and predator constantly evolve together to reach some sort of uneasy balance.

Transforming Principle - Griffith's Experiment About Genetics

Long before DNA was known, Frederick Griffith, established that there was a transforming principle in bacterial genetics in a ground-breaking experiment. He postulated that information could somehow be transferred between different strains of bacteria.

Identical Twins Study - Measuring Effects from Environment and Genetics

Identical twins studies has been used for a long time, to study the effects of environment and genetics on human development. Genetics and environmental factors contribute to intelligence, aggression or substance addictions are some subjects.

History of Biology

• Aristotle's Zoology
• Islamic Scholars and Biology

Basic Concepts

• Biodiversity & Extinction
• Population Biology
• Animals Behavior

Aspects of Zoology

• Predator-Prey Relationships
• Reproduction - Sexual
• Reproduction - Asexual
• The Selfish Gene & Altruism
• Social Insects & Animals
• Animal Intelligence & Learning
• Unique Skills (Radar, Infrared senors, etc.)
• Camouflage & Mimicry
• Specialization
• Defense Mechanisms
• Unique Adaptations

The Animals

• Invertebrates
• Vertebrates
• Ornithology
• Mammalology
• Marine Mammals
• Primitive Animals
• Rarest Animals
• Surprisingly Dangerous Animals
• Poisonous Animals
• Psychology 101
• Flags and Countries
• Capitals and Countries

Oskar Blakstad (Feb 18, 2009). Biology. Retrieved May 17, 2024 from Explorable.com: https://explorable.com/biology

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Biology library

Course: biology library   >   unit 1, the scientific method.

• Controlled experiments
• The scientific method and experimental design

Introduction

• Make an observation.
• Ask a question.
• Form a hypothesis , or testable explanation.
• Make a prediction based on the hypothesis.
• Test the prediction.
• Iterate: use the results to make new hypotheses or predictions.

Scientific method example: Failure to toast

1. make an observation..

• Observation: the toaster won't toast.

2. Ask a question.

• Question: Why won't my toaster toast?

3. Propose a hypothesis.

• Hypothesis: Maybe the outlet is broken.

4. Make predictions.

• Prediction: If I plug the toaster into a different outlet, then it will toast the bread.

5. Test the predictions.

• Test of prediction: Plug the toaster into a different outlet and try again.
• If the toaster does toast, then the hypothesis is supported—likely correct.
• If the toaster doesn't toast, then the hypothesis is not supported—likely wrong.

Logical possibility

Practical possibility, building a body of evidence, 6. iterate..

• Iteration time!
• If the hypothesis was supported, we might do additional tests to confirm it, or revise it to be more specific. For instance, we might investigate why the outlet is broken.
• If the hypothesis was not supported, we would come up with a new hypothesis. For instance, the next hypothesis might be that there's a broken wire in the toaster.

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IDH1 mutation produces R-2-hydroxyglutarate (R-2HG) and induces mir-182-5p expression to regulate cell cycle and tumor formation in glioma

Mutations in isocitrate dehydrogenase 1 and 2 ( IDH1 and IDH2 ), are present in most gliomas. IDH1 mutation is an important prognostic marker in glioma. However, its regulatory mechanism in glioma remains incomplet...

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Therapeutic potential of oleic acid supplementation in myotonic dystrophy muscle cell models

We recently reported that upregulation of Musashi 2 (MSI2) protein in the rare neuromuscular disease myotonic dystrophy type 1 contributes to the hyperactivation of the muscle catabolic processes autophagy and...

Dorsal root ganglion-derived exosomes deteriorate neuropathic pain by activating microglia via the microRNA-16-5p/HECTD1/HSP90 axis

The activated microglia have been reported as pillar factors in neuropathic pain (NP) pathology, but the molecules driving pain-inducible microglial activation require further exploration. In this study, we in...

MicroRNA-721 regulates gluconeogenesis via KDM2A-mediated epigenetic modulation in diet-induced insulin resistance in C57BL/6J mice

Aberrant gluconeogenesis is considered among primary drivers of hyperglycemia under insulin resistant conditions, with multiple studies pointing towards epigenetic dysregulation. Here we examine the role of mi...

Combined transcriptomics and proteomics unveil the impact of vitamin C in modulating specific protein abundance in the mouse liver

Vitamin C (ascorbate) is a water-soluble antioxidant and an important cofactor for various biosynthetic and regulatory enzymes. Mice can synthesize vitamin C thanks to the key enzyme gulonolactone oxidase (Gul...

Novel role of LLGL2 silencing in autophagy: reversing epithelial-mesenchymal transition in prostate cancer

Prostate cancer (PCa) is a major urological disease that is associated with significant morbidity and mortality in men. LLGL2 is the mammalian homolog of Lgl. It acts as a tumor suppressor in breast and hepati...

Rapid development and mass production of SARS-CoV-2 neutralizing chicken egg yolk antibodies with protective efficacy in hamsters

Despite the record speed of developing vaccines and therapeutics against the SARS-CoV-2 virus, it is not a given that such success can be secured in future pandemics. In addition, COVID-19 vaccination and appl...

High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats

Obesity, associated with the intake of a high-fat diet (HFD), and anxiety are common among those living in modern urban societies. Recent studies suggest a role of microbiome-gut-brain axis signaling, includin...

General regulatory factors exert differential effects on nucleosome sliding activity of the ISW1a complex

Chromatin dynamics is deeply involved in processes that require access to DNA, such as transcriptional regulation. Among the factors involved in chromatin dynamics at gene regulatory regions are general regula...

Establishment of primary prostate epithelial and tumorigenic cell lines using a non-viral immortalization approach

Research on prostate cancer is mostly performed using cell lines derived from metastatic disease, not reflecting stages of tumor initiation or early progression. Establishment of cancer cell lines derived from...

The effect of diabetes mellitus on differentiation of mesenchymal stem cells into insulin-producing cells

Diabetes mellitus (DM) is a global epidemic with increasing incidences. DM is a metabolic disease associated with chronic hyperglycemia. Aside from conventional treatments, there is no clinically approved cure...

Control of astrocytic Ca 2+ signaling by nitric oxide-dependent S-nitrosylation of Ca 2+ homeostasis modulator 1 channels

Astrocytes Ca 2+ signaling play a central role in the modulation of neuronal function. Activation of metabotropic glutamate receptors (mGluR) by glutamate released during an increase in synaptic activity triggers ...

Increased levels and activation of the IL-17 receptor in microglia contribute to enhanced neuroinflammation in cerebellum of hyperammonemic rats

Patients with liver cirrhosis may show minimal hepatic encephalopathy (MHE) with mild cognitive impairment and motor incoordination. Rats with chronic hyperammonemia reproduce these alterations. Motor incoordi...

Identification and expression analysis of two steamer-like retrotransposons in the Chilean blue mussel ( Mytilus chilensis )

Disseminated neoplasia (DN) is a proliferative cell disorder of the circulatory system of bivalve mollusks. The disease is transmitted between individuals and can also be induced by external chemical agents su...

Noncoding RNAs in skeletal development and disorders

Protein-encoding genes only constitute less than 2% of total human genomic sequences, and 98% of genetic information was previously referred to as “junk DNA”. Meanwhile, non-coding RNAs (ncRNAs) consist of app...

Cx43 hemichannels and panx1 channels contribute to ethanol-induced astrocyte dysfunction and damage

Alcohol, a widely abused drug, significantly diminishes life quality, causing chronic diseases and psychiatric issues, with severe health, societal, and economic repercussions. Previously, we demonstrated that...

Galectins in epithelial-mesenchymal transition: roles and mechanisms contributing to tissue repair, fibrosis and cancer metastasis

Galectins are soluble glycan-binding proteins that interact with a wide range of glycoproteins and glycolipids and modulate a broad spectrum of physiological and pathological processes. The expression and subc...

Glutaminolysis regulates endometrial fibrosis in intrauterine adhesion via modulating mitochondrial function

Endometrial fibrosis, a significant characteristic of intrauterine adhesion (IUA), is caused by the excessive differentiation and activation of endometrial stromal cells (ESCs). Glutaminolysis is the metabolic...

The long-chain flavodoxin FldX1 improves the biodegradation of 4-hydroxyphenylacetate and 3-hydroxyphenylacetate and counteracts the oxidative stress associated to aromatic catabolism in Paraburkholderia xenovorans

Bacterial aromatic degradation may cause oxidative stress. The long-chain flavodoxin FldX1 of Paraburkholderia xenovorans LB400 counteracts reactive oxygen species (ROS). The aim of this study was to evaluate the...

MicroRNA-148b secreted by bovine oviductal extracellular vesicles enhance embryo quality through BPM/TGF-beta pathway

Extracellular vesicles (EVs) and their cargoes, including MicroRNAs (miRNAs) play a crucial role in cell-to-cell communication. We previously demonstrated the upregulation of bta-mir-148b in EVs from oviductal...

YME1L-mediated mitophagy protects renal tubular cells against cellular senescence under diabetic conditions

The senescence of renal tubular epithelial cells (RTECs) is crucial in the progression of diabetic kidney disease (DKD). Accumulating evidence suggests a close association between insufficient mitophagy and RT...

Effects of latroeggtoxin-VI on dopamine and α-synuclein in PC12 cells and the implications for Parkinson’s disease

Parkinson’s disease (PD) is characterized by death of dopaminergic neurons leading to dopamine deficiency, excessive α-synuclein facilitating Lewy body formation, etc. Latroeggtoxin-VI (LETX-VI), a proteinaceo...

Glial-restricted progenitor cells: a cure for diseased brain?

The central nervous system (CNS) is home to neuronal and glial cells. Traditionally, glia was disregarded as just the structural support across the brain and spinal cord, in striking contrast to neurons, alway...

Carbapenem-resistant hypervirulent ST23 Klebsiella pneumoniae with a highly transmissible dual-carbapenemase plasmid in Chile

The convergence of hypervirulence and carbapenem resistance in the bacterial pathogen Klebsiella pneumoniae represents a critical global health concern. Hypervirulent K. pneumoniae (hvKp) strains, frequently from...

Endometrial mesenchymal stromal/stem cells improve regeneration of injured endometrium in mice

The monthly regeneration of human endometrial tissue is maintained by the presence of human endometrial mesenchymal stromal/stem cells (eMSC), a cell population co-expressing the perivascular markers CD140b an...

Embryo development is impaired by sperm mitochondrial-derived ROS

Basal energetic metabolism in sperm, particularly oxidative phosphorylation, is known to condition not only their oocyte fertilising ability, but also the subsequent embryo development. While the molecular pat...

Fibroblasts inhibit osteogenesis by regulating nuclear-cytoplasmic shuttling of YAP in mesenchymal stem cells and secreting DKK1

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MSC-derived exosomes protect auditory hair cells from neomycin-induced damage via autophagy regulation

Sensorineural hearing loss (SNHL) poses a major threat to both physical and mental health; however, there is still a lack of effective drugs to treat the disease. Recently, novel biological therapies, such as ...

Alpha-synuclein dynamics bridge Type-I Interferon response and SARS-CoV-2 replication in peripheral cells

Increasing evidence suggests a double-faceted role of alpha-synuclein (α-syn) following infection by a variety of viruses, including SARS-CoV-2. Although α-syn accumulation is known to contribute to cell toxic...

Lactadherin immunoblockade in small extracellular vesicles inhibits sEV-mediated increase of pro-metastatic capacities

Tumor-derived small extracellular vesicles (sEVs) can promote tumorigenic and metastatic capacities in less aggressive recipient cells mainly through the biomolecules in their cargo. However, despite recent ad...

Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome

Growing evidence has suggested that Type I Interferon (I-IFN) plays a potential role in the pathogenesis of Down Syndrome (DS). This work investigates the underlying function of MX1, an effector gene of I-IFN,...

The novel roles of YULINK in the migration, proliferation and glycolysis of pulmonary arterial smooth muscle cells: implications for pulmonary arterial hypertension

Abnormal remodeling of the pulmonary vasculature, characterized by the proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) along with dysregulated glycolysis, is a pathognomonic feat...

Electroacupuncture promotes neurogenesis in the dentate gyrus and improves pattern separation in an early Alzheimer's disease mouse model

Impaired pattern separation occurs in the early stage of Alzheimer’s disease (AD), and hippocampal dentate gyrus (DG) neurogenesis participates in pattern separation. Here, we investigated whether spatial memo...

Role of SYVN1 in the control of airway remodeling in asthma protection by promoting SIRT2 ubiquitination and degradation

Asthma is a heterogenous disease that characterized by airway remodeling. SYVN1 (Synoviolin 1) acts as an E3 ligase to mediate the suppression of endoplasmic reticulum (ER) stress through ubiquitination and de...

Advances towards the use of gastrointestinal tumor patient-derived organoids as a therapeutic decision-making tool

In December 2022 the US Food and Drug Administration (FDA) removed the requirement that drugs in development must undergo animal testing before clinical evaluation, a declaration that now demands the establish...

Melatonin alleviates pyroptosis by regulating the SIRT3/FOXO3α/ROS axis and interacting with apoptosis in Atherosclerosis progression

Atherosclerosis (AS), a significant contributor to cardiovascular disease (CVD), is steadily rising with the aging of the global population. Pyroptosis and apoptosis, both caspase-mediated cell death mechanism...

Prenatal ethanol exposure and changes in fetal neuroendocrine metabolic programming

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100 Fascinating Biology Research Paper Topics for Students

15 January, 2021

11 minutes read

Author:  Elizabeth Brown

Biology research is a serious analytical task that usually contains scientific findings, debatable questions, and detailed explanations. Students who are studying biology may get an assignment to find some interesting biological topics to do research for essays, term papers, and scientific reports.

It is quite a challenging and overwhelming task that takes pretty much time and effort. If your topic is not relevant, you won’t be able to include a scientific argument and proceed with further discussion. In this article, you will discover some topics for biology projects that will help you gain attention in a rapidly evolving field like this.

How to Choose Topic for Biology Research Paper?

Well, you’ve been researching for a while now, and you are ready to focus on a particular topic. Professors often ask students to write about something that has not been researched for a hundred times. Among all topics in biology, you should choose the one you are actually interested in. There are certain tips you need to follow before opting for your topic:

• Narrow down the subject matter. Before choosing an interesting biology topic for your research paper, you first need to identify a particular aspect of biology that interests you.
• Examine the existing research papers. You should conduct thorough research on the existing scholarly articles in order to gain a better idea about recent trends in the particular sphere of Biology.
• Brainstorm a particular area . By brainstorming ideas and thoughts, you may find the ideal research topic for biology to focus on.
• Conduct a preliminary research . By conducting preliminary research, you will check the amount of materials covering the selected topic. If you fail to find any information, you should choose another topic.
• Have a look at relevant examples . Checking credible examples is important for biology topics selection. This way, you will learn how to structure your research paper and go about the selected topic.

History of Biology

Do you consider covering the history of Biology in your research? Then, you may refer to the history of all life forms on the planet and explore how they have been researched over time. Here are some topics to dwell on:

• How archeology influences animal biology?
• The latest explanation of Darwin’s theory in modern science
• Edward Jenner and his contribution to the fight against epidemics
• The dead branches of evolution
• Exploring the importance of evolution factors
• Study of modern theories related to the origins of humankind
• The contribution of Antonie van Leeuwenhoek to the science of Biology
• The most significant milestones in the development of behavioral mechanisms in the late XIX – early XX centuries
• Can we trust the Natural Selection Theory? Does it work in the human world?
• The development of genetics over the last century

Immune System Biology Research Topics

The immune system, as our main defense against different diseases and infections, is one of the most important topics for discussion in Biology. Take a look at the following topic examples:

• The resistance capacity of the human immune system
• Why is vaccination important and what are its benefits?
• Problems caused by immunotherapy
• Effects of probiotics on  the prevention of infections
• How poor immunity leads to fatal diseases
• The functions of immune system agents
• The resistance of the human immune system
• Medical conditions caused by immune system malfunction
• How does insomnia influence the human immune system?
• Molecular biology of Human Immunodeficiency Virus

Molecular Biology Topics

Are you looking for a molecular biology issue to cover in your research paper? The following topics represent the latest research on this subject matter.

• The effective ways and tools for effective lifetime prolongation
• The role of genetically modified crops for the national economy
• Molecular biology research in the United States
• Can Ebola be viewed as a biological weapon?
• The effect on antibiotics on cells
• Challenges caused by diseases to molecular biology
• Does molecular biological research of rare genetic disorders provide us with the keys to understanding cancer and other diseases?
• What are the biological reasons behind food intolerances?
• Production of growth hormone and insulin in genetic engineering
• Molecular chaperones and their role in polypeptides folding

Genetic Researches Biology Topics

Research on genetic concepts can reveal intriguing insights into human nature and potential. The variety of options here is unlimited. Some of them include the following:

• How to solve the ethical dilemma of human cloning?
• The recent implementation of genetic disorders treatment
• Modern technology in  DNA analysis
• The process of DNA modification on smoking females
• Methods of the sequencing of nucleotide sequences of DNA
• DNA Modifications and its Effects on Humans
• Genetics of chromosomal diseases related to structural chromosome rearrangements
• Genetics behind human physical features
• DNA diagnosis of hereditary and infectious diseases
• Can DNA influence the process of aging?

Neurobiology Research Topics

The human brain is intriguing, as there are always some new things to learn. The following topics have a great study potential:

• The improvement of brain activities with the most advanced neurobiology aids
• The innovative technologies in neurobiology
• Does gut bacteria lead to depression?
• Genetic defects that cause schizophrenia
• The molecular and gene regulatory signature of a neuron
• The influence of music on cognitive processes in a human brain
• What are the negative consequences associated with neurosurgery?
• Formation of thinking, speech, and consciousness of an average person
• Neurobiological Explanation of Sleep
• The role of neuroscience in the development of robotic technologies

Plant Research Topics

Are you interested in writing a paper about plants? Here are some of the latest ideas in botany to get inspiration by: 

• How does climate change affect biodiversity in Australia?
• The evolutionary factors that affect plant growth
• A comparative analysis of invasive plants in New Zealand
• Friction in the plant world
• How modern technology can facilitate plant disease treatment
• Disease resistance mechanism in plants
• An extensive research on plant-associated microbes and available genomic tools
• Feature and functions of photosynthesis
• Impact of electric current on plant cells
• Plant cells plastids structure and function

Ecological Subjects

Ecology-concerning subjects are becoming more and more popular as society has to deal with the results of human behavior all the time. In your biology research study, you can offer some new solutions to ecological problems in order to turn the world into a better place. Let’s review some popular topic examples:

• Exploring the relevance of chemical ecology in the context of Oceania
• The impact of Ecological factors on animal behavior
• Ways animals and plants adapt to fast-changing environment
• Explore the ecological footprint of cotton production
• The ecological approach to sustainable marine research
• Why does biodiversity need to be conserved?
• Consequences of building the Hetch Hetchy valley dam
• What causes toxic algae bloom?
• Indoor air pollution: causes and risks
• The devastating impact of deforestation in Amazon forests

If you are interested in the animal world , feel free to write about it in your research paper. By conducting a deep analysis of one phenomenon or species, you may shed light on the growing problems. Some of the burning topics to consider include the following:

• How the mechanism of camouflage is used by sea animals?
• How does veganism affect meat production?
• How do humans influence the diversity of animal species?
• The mechanism of resistance in animals
• Domestication: can foxes become domestic animals?
• Possibility of homosexual connections in the world of animals
• The future of the planet through the prism of Species Extinction
• Can beauty products testing on animals be viewed as ethical?
• Evolutionary connections between moths and butterflies
• The importance of home diet for dogs

Behavior and Hormones

You can also share ideas on how human hormones influence their mood and well-being. A short list of topic samples covers the following: 

• How hormones affect women’s behavior during pregnancy
• Psychopathic Disorders: Are They Hormone-Specific?
• The hormones disorder and constant depression
• How does your brain control your behavior?
• The three main psychopathic disorders influenced by hormones
• Analyze the features of oxytocin that turn this hormone into a love drug
• How to generate growth hormone by means of genetic engineering methods?
• Biologic basis of the bipolar disorder
• The influence of diabetes and its potential threats
• The role of hormones in women’s health

Easy Biology Research Topics

If you don’t know what to write about in your biology research paper, you can use one of the most common topics. Although they have been widely covered by scientists, it doesn’t mean they are not suitable for further research. These topic ideas might come in handy:

• How to prevent the risks related to global warming?
• The future prospects of molecular biology in Europe
• Is growing organs for transplantation in laboratories ethical?
• How is melatonin used for therapy purposes?
• What is the value of sustainability in Biology?
• Explore the effects of marijuana on the human brain. Should the use of marijuana become legal?
• Accuracy of DNA testing in the modern medical environment
• Different ecological pyramids and the ratio of organisms at each of their levels
• The positive and negative aspects of transgenic crops
• Various means of wildlife protection

Biology research is one of the most complicated academic assignments that needs to be written according to strict requirements. While checking the variety of biology research topics, you should be ready to deal with certain problems, such as a poor understanding of the subject matter, its value for society, etc. Try to select a brief and concise topic that can be supported with relevant and up-to-date evidence. Make sure to conduct thorough research by using all the available tools and methods you know. Remember that the importance and timely revelation of the topic increases your chances to get an excellent grade eventually.

If you are still unsure on whether you can cope with your task – you are in the right place to get help. Our essay writers know the perfect answer to the question “Who can write my paper?”

A life lesson in Romeo and Juliet taught by death

Due to human nature, we draw conclusions only when life gives us a lesson since the experience of others is not so effective and powerful. Therefore, when analyzing and sorting out common problems we face, we may trace a parallel with well-known book characters or real historical figures. Moreover, we often compare our situations with […]

Ethical Research Paper Topics

Writing a research paper on ethics is not an easy task, especially if you do not possess excellent writing skills and do not like to contemplate controversial questions. But an ethics course is obligatory in all higher education institutions, and students have to look for a way out and be creative. When you find an […]

Art Research Paper Topics

Students obtaining degrees in fine art and art & design programs most commonly need to write a paper on art topics. However, this subject is becoming more popular in educational institutions for expanding students’ horizons. Thus, both groups of receivers of education: those who are into arts and those who only get acquainted with art […]

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Biological sciences encompasses all the divisions of natural sciences examining various aspects of vital processes. The concept includes anatomy, physiology, cell biology, biochemistry and biophysics, and covers all organisms from microorganisms, animals to plants.

Decoding gene regulation with CRISPR perturbations

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Rules of selective condensation in cells

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Quantifying stochasticity in the aging DNA methylome

Aging-related DNA methylation changes are numerous. Their precise measurement has opened new avenues to explore aging-related disease pathology, including the construction of chronological and biological age predictors (termed DNA methylation ‘clocks’). Three studies investigate the substantial stochastic contribution to these epigenetic changes and further our understanding of aging biology, as well as of these predictors.

• Christopher G. Bell

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Recruitment of plasma cells from IL-21-dependent and IL-21-independent immune reactions to the bone marrow

The mechanisms driving B cell differentiation into resident bone marrow plasma cells (BMPC) remain unclear. Here the authors use single cell sequencing and BMPC phenotyping to infer developmental pathways and regulation by IL-21 in germinal centres to promote maintenance of BMPC after vaccination in humans.

• Marta Ferreira-Gomes
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Cingulate microstimulation induces negative decision-making via reduced top-down influence on primate fronto-cingulo-striatal network

The neuronal mechanism of how the prefrontal cortex exerts top-down influence on the cingulo-striatal network during decision-making in depressive states is not fully understood. Here authors showed that negative bias in decision-making can be artificially induced via stimulating such neural network and they observed diminished top-down influences correlating with the depressive state.

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News and Comment

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Brain functional networks and psychiatric disorders

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PARP1-DNA co-condensation: the driver of broken DNA repair

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Solving the Wnt nuclear puzzle

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Example hatchery research

Preparation of Primary Myogenic Precursor Cell/Myoblast Cultures from Basal Vertebrate Lineages  by: Jacob Michael Froehlich, Iban Seiliez, Jean-Charles Gabillard, Peggy R. Biga Department of Biology, University of Alabama at Birmingham

Full Abstract:

Due to the inherent difficulty and time involved with studying the myogenic program in vivo, primary culture systems derived from the resident adult stem cells of skeletal muscle, the myogenic precursor cells (MPCs), have proven indispensable to our understanding of mammalian skeletal muscle development and growth. Particularly among the basal taxa of Vertebrata, however, data are limited describing the molecular mechanisms controlling the self-renewal, proliferation, and differentiation of MPCs. Of particular interest are potential mechanisms that underlie the ability of basal vertebrates to undergo considerable post larval skeletal myofiber hyperplasia (i.e. teleost fish) and full regeneration following appendage loss (i.e. urodele amphibians). Additionally, the use of cultured myoblasts could aid in the understanding of regeneration and the recapitulation of the myogenic program and the differences between them. To this end, we describe in detail a robust and efficient protocol (and variations therein) for isolating and maintaining MPCs and their progeny, myoblasts and immature myotubes, in cell culture as a platform for understanding the evolution of the myogenic program, beginning with the more basal vertebrates. Capitalizing on the model organism status of the zebrafish (Danio rerio), we report on the application of this protocol to small fishes of the cyprinid clade Danioninae. In tandem, this protocol can be utilized to realize a broader comparative approach by isolating MPCs from the Mexican axolotl (Ambystomamexicanum) and even laboratory rodents. This protocol is now widely used in studying myogenesis in several fish species, including rainbow trout, salmon, and sea bream.

Introduction

This research is being used to provide "understanding whether MPC cell fate choice plays a role in skeletal muscle hyperplasia versus hypertrophy"

Outside of the class Mammalia, however, the conservation and/or divergence of mechanisms controlling myogenesis are poorly understood, largely due to the difficulty in culturing myogenic precursor cells (MPCs) and myoblasts from various taxa. Indeed, primary myoblast cultures have only been described in three birds, one reptile, a few amphibians, and some fishes. Continuous myogenic cell lines from vertebrates other than rodents are even more rare, with the only non-mammalian myogenic cell line being derived from Japanese quail (Cortunix japonica). Despite many attempts at immortalization, a teleost myogenic cell line remains elusive and a protocol for efficient transfection of these cells was only published this year. Thus, clear and well-optimized protocols for culturing primary MPCs and myoblasts from a variety of vertebrates are very much needed to not only further expand our knowledge of the evolution of the myogenic program, but to employ the power of comparative physiology to make breakthroughs in the treatment of human skeletal muscle diseases and disorders.

Dale Hollow NFH is able to provide any size of juvenile trout for UAB research, but they consistently request 2.5-3” fingerlings.

The age of the fish to be used is of critical importance. While fish of two different species may be of similar weights, a younger fish of one species will possess more MPCs than an older fish of another species. As a general rule, younger fish, especially when working with  salmonids, are best.

Description of a blender as an electric tissue homogenizer:

Poor dissociation will hinder enzymatic digestion and decrease cell yield. Although it may be tempting to consider, the use of electric tissue homogenizers dramatically lowers cell viability despite its obvious convenience, at least with piscine MPCs.

Average number of myogenic precursor cells isolated from 1 gram of muscle tissue from  teleost species: Oncorhynchus mykiss (rainbow trout).

The myogenic program, in whichever species examined, can be most easily studied through an in vitro system. Indeed, upon isolation, myogenic precursor cells (MPCs) in fish or myosatellite cells (MSCs) in mammals readily enter this highly regulated process involving the proliferation, cell cycle withdrawal, and terminal differentiation of myoblasts and the fusion of those myoblasts into nascent myotubes. The general lack of transgenic gene reporter strains of piscine species (with the possible exception of the zebrafish and rainbow trout) constrains in vivo work of MPC/MSC activation, proliferation, and differentiation, and thus the in vitro system presented here is an attractive platform for studies in fish species.

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