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RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES,
BANGALORE, KARNATAKA
ANNEXURE-11
PROFORMA FOR REGISTRATION OF SUBJECTS FOR DISSERTATION
1. NAME OF THE
CANDIDATE AND
DR. KAVYA K
POST GRADUATE
DEPT OF GENERAL MEDICINE ,
ESIC MEDICAL COLLEGE AND PGIMSR ,
RAJAJINAGAR,
BENGALURU-560010
2. NAME OF THE
INSTITUTION
3. COURSE OF THE
STUDY AND SUBJECT M.D. – GENERAL MEDICINE
4. DATE OF ADMISSION
TO COURSE 31-05-2012
5. TITLE OF TOPIC
“AN OBSERVATIONAL STUDY OF ANAEMIA AND ITS
UNDERLYING CAUSES IN MEDICAL INTENSIVE CARE UNIT.”
BRIEF RESUME OF THE INTENDED STUDY:
6.1 NEED FOR THE STUDY:
Anemia is common in critically ill patients and appears early during their intensive
care unit (ICU) course. By day 3 after ICU admission, almost 95% of patients are anemic.[1–3] The anemia in these critically ill patients persists throughout their ICU and hospital
stay, with or without red blood cell (RBC) transfusion.[3]
Delivery of oxygen to tissues depends upon hemoglobin level and tissue perfusion
by oxygenated blood; anemia will lead to a decreased capacity of oxygen transport, which
is compensated by cardiac compensatory mechanisms. In critically ill patients these
mechanisms might not be sufficient eventually resulting in tissue hypoxia and progression
to multiple organ dysfunction syndromes. The presence of anemia patients in ICU has been
associated with worse outcomes including increased lengths of stay and increased
mortality.[4]
Anemia is a hemoglobin concentration in blood that is below the expected value,
when age, gender, pregnancy and certain environmental factors, such as altitude, are taken
into account. The World Health Organization (WHO) defines anemia as a hemoglobin
<13 g/dl (hematocrit <39%) for adult males and <12 g/dl (hematocrit <36%) for adult non-
pregnant females. [5, 6] There are no universally agreed grades of severity for anemia during
critical illness.
Among the causes of anemia in the critically ill, important are sepsis (inflammation)
induced bone marrow suppression, blood loss especially gastrointestinal bleeding, blood
sampling, chronic renal failure, drug-induced hemolytic anemia, nutritional deficiencies
and worm infestation.[7,8] Anemia of critical illness is similar as anemia of Inflammation
and anemia of chronic disease as it develops acutely in states of inflammation. Anemia of
inflammation is the second most common cause of anemia after iron deficiency.[9]
A proper identification of anemia and its underlying causes in ICU patients is required
because various disorders may necessitate different diagnostic and therapeutic management
strategies. It will be helpful to select appropriate treatment options like blood transfusion,
erythropoietin therapy, and iron supplementation which influence the outcome in these
critically ill patients.
6.2 REVIEW OF LITERATURE Corwin et. al study in the USA examined 489 admissions to ICUs the mean hemoglobin
concentration at ICU admission was 11.0 g/dl. Almost two-thirds of patients had a
hemoglobin concentration <12 g dl at ICU admission.[3]
Vincent et. al in a cohort study of 3534 patients admitted to 146 Western European
ICUs with varying case mix found that the mean hemoglobin concentration at ICU
admission was 11.3 g/dl. Sixty-three per cent of patients had a hemoglobin concentration
<12 g/dl on ICU admission and 29% of patients had an admission hemoglobin
concentration <10 g/dl.[4]
A cohort study by Bahlas S et. al., out of the 100 patients, 82% (82 patients) were
anemic with Hb average of 10.06 + 0.28, 48 of whom had blood transfusion. Sepsis was
the most common clinical setting associated with anemia in 72% of the patients followed
by Chronic Renal Failure in 56% of the patients. The others being gastrointestinal
bleeding, hemolysis and internal hemorrhage. [9]
Anemia is common in heart failure populations, with the majority of studies indicating
prevalence >20%. In most reported studies anemia is an independent predictor of increased
mortality risk and increased risk of hospitalization for heart failure.[10]
In a prospective cohort study by N Manchal, S Jayaram causes identified for anemia in
ICU were 33% due to sepsis, 9% due to chronic kidney disease,8% each for GI bleed,
internal bleed and protozoa infections.[11]
Tanne D et. al concluded in a cohort study as WHO-defined anemia was common in both
men and women among patients with acute stroke and predicted poor outcome.[12]
Hebert et al. studied 4,470 patients Critically ill patients admitted to ICU; survivors:
(n = 3,469), non-survivors: (n = 1,001) Survivors had higher Hb levels than non-survivors.[13]
6.3 OBJECTIVES OF THE STUDY1. To study occurrence of anemia among critically ill patients and its contribution to ICU
related morbidity.
2. To study the etiological factors that contributes to anemia in critically ill patients.
7 MATERIALS AND METHODS
7.1 SOURCE OF THE DATA The study includes patient selected from ICU at Employees State Insurance Corporation-
Medical Collage- Post Graduate Institute of Medical Sciences and Research [ESIC-MC-
PGIMSR] over a period of 18 months.
7.2 METHOD OF COLLECTION OF DATA Patients satisfying inclusion criteria are enrolled within 24 hours of admission to ICU
after informed consent.
Complete hemogram noted on first day, third day and at the time of discharge or transfer
from ICU.C-reactive protein measured on first day and at the time of discharge or transfer
Other investigations as advised by attending physician based on primary diagnosis are
noted as relevant to the study.
Sample size: 60
Study design: observational study
Statistical analysis: The data collected in this study will be analyzed statistically using
descriptive statistics.
INCLUSION CRITERIA:1. Patients aged above 18 years admitted under medicine department.[11]
2. Males with hemoglobin <13 g/dl (hematocrit <39%) and females with<12g/dl
(hematocrit <36%) [5,6]
3. APACHE II SCORE ≥ 20 on the day of admission[4,12] or Patient on mechanical
ventilator[13]
EXCLUSION CRITERIA:1. Patient under age 18 years
2. Patient with known congenital anaemias
3. HIV positive patients
4. Patient with known malignancy and on chemotherapy
5. Pregnant patients
7.3 DOES THE STUDY REQUIRE ANY INVESTIGATIONS OR
INTERVENTIONS TO BE CONDUCTED IN PATIENTS OR OTHER
7.4 HAS ETHICAL CLEARANCE BEEN OBTAINED FROM YOUR
INSTITUTION :YES
8. REFERENCES:
1. Corwin HL, Gettinger A, Rodriguez RM, Pearl RG, Gubler KD, Enny C, Colton T,
Corwin MJ: Efficacy of recombinant human erythropoietin in the critically ill patient: a
randomized, double-blind, placebo-controlled trial. Crit Care Med 1999; 27:2346-2350.
2. Rodriguez RM, Corwin HL, Gettinger A, Corwin MJ, Gubler D, Pearl RG. Nutritional
deficiencies and blunted erythropoietin response as causes of the anemia of critical illness.
J Crit Care 2001; 16:36-41.
3. Corwin HL, Gettinger A, Pearl RG, Fink MP, Levy AM, Abraham E, MacIntyre NR,
Shabot M, Dun MS, Shapiro MJ. The CRIT study: Anemia and blood transfusion in the
critically ill: current clinical practice in the United States. Crit Care Med 2004; 32:39-52.
4. Vincent JL, Baron JF, Reinhart K, et al. Anaemia and blood transfusions in critically ill
patients. JAMA 2002; 288:1499–507.
5. Longo D L et al. Harrison´s Principles of Internal Medicine. 18 th edition. Vol.I. New
York: McGraw-Hill; 2012: 448-9.
6. Nutritional anaemia’s. Report of WHO scientific group. World Health Organ Tech Rep
Ser1968; 405:5-37.
7. Walsh T.S, Ezz-El-Din Saleh. Anaemia during critical illness. British Journal of
Anaesthesia 2006; 97 (3): 278–91.
8. Irwin, Richard S., Rippe, James M. Irwin and Rippe's Intensive Care Medicine. 7th
Edition. Lippincott Williams & Wilkins: 2011; Sec IX Chap 112:1253-4.
9. Bahlas S, Faydhi A , Ahmed M.A. Prospective Study on Anemia and Blood Transfusion
in Critically ill Patients.WebmedCentral GENERAL MEDICINE 2011; 2(4):WMC001836.
10. Tang Y, Katz SD. The prevalence of anemia in chronic heart failure and its impact on
the clinical outcomes. Heart Fail Rev. 2008 Dec; 13(4):387-92
11. Manchal N, Jayaram S. A prospective cohort study on anemia and blood transfusion in
critically ill patients. Indian J Crit Care Med 2007; 11:182-5.
12. Tanne D, Molshatzki N, Merzeliak O, Tsabari R, Toashi M, Schwammenthal Y.
Anaemia status, haemoglobin concentration and outcome after acute stroke: a cohort study.
BMC Neurol 2010; 10:22.
13. Hebert PC, Wells G, Tweeddale M, et al. Does transfusion practice affect mortality in
critically ill patients? Transfusion Requirements in Critical Care (TRICC) Investigators and
the Canadian Critical Care Trials Group. Am J Resp Crit Care Med 1997; 155:1618–1623.
14. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. "APACHE II: a severity of
disease classification system". Critical Care Medicine 1985; 13 (10): 818–29.
15. Wang MP, Jiang L, Zhu B, Jiang Q, Xi XM. Clinical observational study of anemia in
mechanically ventilated patients. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2012 Feb;
24(2): 70-3.
9. SIGNATURE OF CANDIDATE
10.REMARKS OF THE GUIDE:
Anemia in ICU has diagnostic and therapeutic implications. Hence study is relevant with practical implications.
11. 11.1 NAME AND DESIGNATION( IN BLOCK LETTERS) OFGUIDE
DR.T.ANIL KUMAR, MDPROFESSOR AND HEAD OF THE DEPARTMENT,DEPARTMENT OF GENERAL MEDICINE,ESIC-MC PGIMSR,RAJAJINAGAR,BENGALURU-560010
11.2 CO-GUIDE ( if any ) DR.V.SRINIVASA MURTHY, MDPROFESSOR AND HEAD OF THE DEPARTMENT,DEPARTMENT OF PATHOLOGY,ESIC-MC PGIMSR,RAJAJINAGAR,BENGALURU-560010
11.3 HEAD OF THE DEPARTMENT
11.4 SIGNATURE
11.5 REMARKS OF THE CHAIRMAN & PRINCIPAL
11.6 SIGNATURE
11.7 PRINCIPAL OF THE INSTITUTTION
Dr. B. RAJEEVA SHETTY, MSDEAN, ESIC MEDICAL COLLEGE & POSTGRADUATE INSTITUTE OF MEDICAL SCIENCE AND RESEARCH, RAJAJINAGAR, BENGALURU-560010
Case No: Hospital- IP / OP No:
Address: Occupation:
History of fever – type Duration Degree Associated factors History of cough –productive Non – productive History of burning micturition History of pain abdomen/ vomiting/loose stoolsHistory of blood in vomitus / stools / black tarry stoolsHistory of recent bleeding from any orifices- menstrual, gum bleeding or othersHistory of headache / altered sensorium
Co-morbidities- Hypertension/ diabetes/ chronic renal failure/ chronic obstructive pulmonary disease/ ischemic heart disease/ tuberculosis/ epilepsy/ cirrhosis of liver
PAST HISTORY -
GPE- General Physical Examination:
General appearance:
Height / weight Temperature
Pallor: Clubbing: Icterus: Cyanosis: Edema:
Pulse: BP: Respiratory rate: Saturation:
Systemic examination:
Investigations:
APACHE II score-Arterial blood gas analysis-
Mechanical ventilation-
1. Complete Hemogram:On day 1On day 3On day of discharge or transfer
On day 1On day of discharge or transfer
Other investigations as ordered by attending physician based on primary diagnosis:
PT, aPTT, INR Smear for MP, Serological tests for dengue, leptospirosis Liver function tests Renal function tests Thyroid function tests Iron studies Serum B12, Folic acid levels Bone marrow aspiration & biopsy Blood culture & sensitivity Urine routine analysis Urine culture & sensitivity Sputum gram stains & culture sensitivity Chest x ray Ultra sonogram
Other relevant investigations as required;
TREATMENT GIVEN;
Number of units of blood transfused:
CONSENT FORM
Participant’s name: Age: Sex:
Title of the study: AN OBSERVATIONAL STUDY OF ANAEMIA AND ITS ETIOLOGICAL PROFILE IN MEDICAL INTENSIVE CARE UNIT.
The details of the study have been provided to me in writing and explained to me/us in my/our own language. I/we confirm that I have understood the above study and had the
opportunity to ask questions. I/we understand that my participation in the study is voluntary and that I/we am free to withdraw at any time, without giving any reason, without the medical care that will normally be provided by the hospital being affected. I/we agree not to restrict the use of any data or results that arise from this study provided such a use is only for scientific purpose(s). I/we have been given an information sheet giving details of the study. I/we fully consent for detailed examination, investigations and to participate in the above study.
Signature of the participant/ next of kin: ______________________ Date: _____________
Signature of the witness ________________________ Date: _____________
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RJNS Vol No: 14 Issue No: 1 eISSN: pISSN:
Dear Authors, We invite you to watch this comprehensive video guide on the process of submitting your article online. This video will provide you with step-by-step instructions to ensure a smooth and successful submission. Thank you for your attention and cooperation.
Welcome To RGUHS National Journal of Nursing Sciences
The RGUHS Journal of Nursing Sciences (RJNS) is the official publication of Rajiv Gandhi University of Health Sciences. The journal considers for publication original articles (research) dealing with different fields such as Medical-Surgical, Mental Health, Community Health, Maternal and Child Health Nursing, as well as Nursing Education and Administration; case reports related to any of these fields; review articles and columns (short communications pertaining to any discipline in nursing practice, education and administration).
Only papers that are likely to make a significant contribution to the existing state of knowledge in nursing practice, education and administration will be published.
With profound pleasure, we release the upcoming issue of RGUHS Journal of Nursing Sciences.
RGUHS Journal is a showcase of ingenuity, innovation and constructive research of faculty and students of this university. Journal publication is expected to benefit the university in many ways it brings scholarly recognition and credibility to the university, it would also contribute for the career development of faculty and researchers. These new ideas, research and development activities finally translate into overall development of community and society at large.
I whole heartedly appreciate the efforts of the Editors in Chief and Editorial board members.
I would also like to congratulate and thank all the authors who have contributed towards this Journal
Dr. M. K. Ramesh
Vice Chancellor
We acknowledge HealthMinds Consulting Pvt. Ltd. for constant support and assistance in managing the journal to reach our goals.
© 2024 HealthMinds Consulting Pvt. Ltd. unless otherwise stated.
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Rajiv Gandhi University of Health Sciences, Karnataka; Curriculum Development Cell: Online Registration of Subjects for Synopsis: Message for Reviewers: Synopsis Review
Although your thesis or dissertation may be prepared on a computer, consider the following requirements for meeting the standards. Paper Use only one side of high-quality, plain white (unlined in any way) bond paper, minimum 20-lb weight, and 8-1/2" x 11" in size. Erasable paper should not be used. Type Size and Print
Rajiv Gandhi University of Health Sciences, Karnataka; Curriculum Development Cell: Synopsis Titles
Note:-. * Thesis Online submission cut of date limit is exceeded. Please check mentioned circular document. * Students/Candidates who have not been allotted register number may contact the office of Registrar/Registrar (RE)
Rguhs Thesis Synopsis - Free download as PDF File (.pdf), Text File (.txt) or read online for free. This document discusses writing a thesis synopsis for the Rajiv Gandhi University of Health Sciences program. It notes that crafting a thesis synopsis is an overwhelming task that requires meticulous research, organization, and analysis. It states that seeking professional assistance can help ...
Thesis Submission . If you're New User ? Enter the Synopsis. No: Enter the Password: Enter the Captcha * Forgot Password ?? Note:- Students/Candidates who have not been allotted register number may contact the office of Registrar/Registrar (RE) Designed and Developed with the technical support of NIC - KSU, Bangalore.
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Fetch Student Details. Student Registration Number *. Student Mobile Number *. Student Email Address *. Date Of Birth *.
Rguhs Dissertation Synopsis Format - Free download as PDF File (.pdf), Text File (.txt) or read online for free. - Writing a dissertation is an extremely challenging task that requires extensive research, analysis, and clear writing abilities. Students often feel overwhelmed by the large scope of the work. - The company understands the difficulties students face in writing dissertations.
Synopsis Number Verification. Synopsis Registration Number: Designed and Developed with the technical support of NIC - KSU, Bangalore. Version - 1.0.0.3-28 1.0.0.3-28
The Digital Library initiative at RGUHS is first of its kind in the country in promoting e-learning culture and e-readiness preparedness for accessing huge amount of scholarly international Medical e-journals and e-books. With the State-of-the-art infrastructures, RGUHS developed the Digital Library and information centre for identifying ...
Last date for submission of Medical Synopsis was 23/03/2024 and AHS 30/06/2024: DENTAL: Last Date for Submission of Dental Synopsis is extended to 15/05/2024: AYURVEDA: Last date for submission Ayurveda Synopsis is 31/05/2024. Ref RGUHS/ADM/PG AYUSH/COE/2023-24 Dt. 16/11/2023: NURSING: Last Date for Submission of Nursing Synopsis is extended to ...
THESIS SYNOPSIS RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES, BANGALORE, KARNATAKA ANNEXURE-11 PROFORMA FOR REGISTRATION OF SUBJECTS FOR DISSERTATION 1. NAME OF THE CANDIDATE…
Effectiveness of self-instructional module regarding prevention of ventilator associated pneumonia among paediatric staff nurses in selected hospitals at Bangalore. Ventilator Associated Pneumonia (VAP) is one of the most common hospitals acquired infection and is associated with increased mortality rate. Prevention of VAP is very important ...
Guide Recognition letter issued by the RGUHS Synopsis registration form ( when the student submit the Intended work and take a print out ) - which should have been signed by the student, Guide , co-guide, HOD, Principal etc Institutional Ethical Clearance certificate - which should have been counter signed by the Guide with seal.
No. RGUHS/Ph.D/ORD-UGC/2017-18 NOTIFICATION Date: 14.05.2019 Sub: Ref: ... Proforma for Registration of topic for Ph.D Thesis (Preliminary Synopsis) Note: Candidate can only register through RGUHS recognized Ph.D Department. 1. 2. 3. Name of the Candidate and Address (in block letters)
Dissertation Guidelines Rguhs - Free download as PDF File (.pdf), Text File (.txt) or read online for free. The document provides guidance on navigating the challenges of dissertation writing according to Rguhs (Rajiv Gandhi University of Health Sciences) guidelines. It notes that dissertation writing requires extensive research, adherence to formatting guidelines, and synthesizing information ...
Title: The Technical Perspectives of Electronic Information Resources and its Use Pattern among Users of Medical College Libraries Affiliated to Rajiv Gandhi University of Health Sciences Karnataka A Case Study
The RGUHS Journal of Nursing Sciences (RJNS) is the official publication of Rajiv Gandhi University of Health Sciences. The journal considers for publication original articles (research) dealing with different fields such as Medical-Surgical, Mental Health, Community Health, Maternal and Child Health Nursing, as well as Nursing Education and ...
Rguhs Dissertation Topics in Nursing - Free download as PDF File (.pdf), Text File (.txt) or read online for free.
Rajiv Gandhi University of Health Sciences, Karnataka: Curriculum Development Cell: Instructions: View Registered Entries: Synopsis Review
Hard Copies of Ph.D Thesis; Extension of submission of Preliminary Synopsis for Registration to Ph.D Courses for the academic year 2023-24; ... RGUHS Scientific Publications; MSc Nursing Log Book; Research Grants for the year 2010-11 : Rajiv Gandhi University of Health Sciences, 4th 'T' Block, Jayanagar,Bengaluru - 560 041,Karnataka,India ...
Rguhs Dissertation Synopsis Proforma - Free download as PDF File (.pdf), Text File (.txt) or read online for free. The document discusses the challenges of writing a dissertation synopsis for RGUHS, including the extensive research, analysis, and writing required. It notes that many students feel overwhelmed by the large scope of the project and pressure to meet deadlines.