research paper guidelines middle school

Scaffolding Methods for Research Paper Writing

• Resources & Preparation
• Instructional Plan
• Related Resources

Students will use scaffolding to research and organize information for writing a research paper. A research paper scaffold provides students with clear support for writing expository papers that include a question (problem), literature review, analysis, methodology for original research, results, conclusion, and references. Students examine informational text, use an inquiry-based approach, and practice genre-specific strategies for expository writing. Depending on the goals of the assignment, students may work collaboratively or as individuals. A student-written paper about color psychology provides an authentic model of a scaffold and the corresponding finished paper. The research paper scaffold is designed to be completed during seven or eight sessions over the course of four to six weeks.

Featured Resources

• Research Paper Scaffold : This handout guides students in researching and organizing the information they need for writing their research paper.
• Inquiry on the Internet: Evaluating Web Pages for a Class Collection : Students use Internet search engines and Web analysis checklists to evaluate online resources then write annotations that explain how and why the resources will be valuable to the class.

From Theory to Practice

• Research paper scaffolding provides a temporary linguistic tool to assist students as they organize their expository writing. Scaffolding assists students in moving to levels of language performance they might be unable to obtain without this support.
• An instructional scaffold essentially changes the role of the teacher from that of giver of knowledge to leader in inquiry. This relationship encourages creative intelligence on the part of both teacher and student, which in turn may broaden the notion of literacy so as to include more learning styles.
• An instructional scaffold is useful for expository writing because of its basis in problem solving, ownership, appropriateness, support, collaboration, and internalization. It allows students to start where they are comfortable, and provides a genre-based structure for organizing creative ideas.
• In order for students to take ownership of knowledge, they must learn to rework raw information, use details and facts, and write.
• Teaching writing should involve direct, explicit comprehension instruction, effective instructional principles embedded in content, motivation and self-directed learning, and text-based collaborative learning to improve middle school and high school literacy.

Common Core Standards

This resource has been aligned to the Common Core State Standards for states in which they have been adopted. If a state does not appear in the drop-down, CCSS alignments are forthcoming.

State Standards

This lesson has been aligned to standards in the following states. If a state does not appear in the drop-down, standard alignments are not currently available for that state.

NCTE/IRA National Standards for the English Language Arts

• 1. Students read a wide range of print and nonprint texts to build an understanding of texts, of themselves, and of the cultures of the United States and the world; to acquire new information; to respond to the needs and demands of society and the workplace; and for personal fulfillment. Among these texts are fiction and nonfiction, classic and contemporary works.
• 2. Students read a wide range of literature from many periods in many genres to build an understanding of the many dimensions (e.g., philosophical, ethical, aesthetic) of human experience.
• 3. Students apply a wide range of strategies to comprehend, interpret, evaluate, and appreciate texts. They draw on their prior experience, their interactions with other readers and writers, their knowledge of word meaning and of other texts, their word identification strategies, and their understanding of textual features (e.g., sound-letter correspondence, sentence structure, context, graphics).
• 4. Students adjust their use of spoken, written, and visual language (e.g., conventions, style, vocabulary) to communicate effectively with a variety of audiences and for different purposes.
• 5. Students employ a wide range of strategies as they write and use different writing process elements appropriately to communicate with different audiences for a variety of purposes.
• 6. Students apply knowledge of language structure, language conventions (e.g., spelling and punctuation), media techniques, figurative language, and genre to create, critique, and discuss print and nonprint texts.
• 7. Students conduct research on issues and interests by generating ideas and questions, and by posing problems. They gather, evaluate, and synthesize data from a variety of sources (e.g., print and nonprint texts, artifacts, people) to communicate their discoveries in ways that suit their purpose and audience.
• 8. Students use a variety of technological and information resources (e.g., libraries, databases, computer networks, video) to gather and synthesize information and to create and communicate knowledge.
• 12. Students use spoken, written, and visual language to accomplish their own purposes (e.g., for learning, enjoyment, persuasion, and the exchange of information).

Materials and Technology

Computers with Internet access and printing capability

• Research Paper Scaffold
• Example Research Paper Scaffold
• Example Student Research Paper
• Internet Citation Checklist
• Research Paper Scoring Rubric
• Permission Form (optional)

Preparation

Student objectives.

Students will

• Formulate a clear thesis that conveys a perspective on the subject of their research
• Practice research skills, including evaluation of sources, paraphrasing and summarizing relevant information, and citation of sources used
• Logically group and sequence ideas in expository writing
• Organize and display information on charts, maps, and graphs

Session 1: Research Question

You should approve students’ final research questions before Session 2. You may also wish to send home the Permission Form with students, to make parents aware of their child’s research topic and the project due dates.

Session 2: Literature Review—Search

Prior to this session, you may want to introduce or review Internet search techniques using the lesson Inquiry on the Internet: Evaluating Web Pages for a Class Collection . You may also wish to consult with the school librarian regarding subscription databases designed specifically for student research, which may be available through the school or public library. Using these types of resources will help to ensure that students find relevant and appropriate information. Using Internet search engines such as Google can be overwhelming to beginning researchers.

Session 3: Literature Review—Notes

Students need to bring their articles to this session. For large classes, have students highlight relevant information (as described below) and submit the articles for assessment before beginning the session.

Checking Literature Review entries on the same day is best practice, as it gives both you and the student time to plan and address any problems before proceeding. Note that in the finished product this literature review section will be about six paragraphs, so students need to gather enough facts to fit this format.

Session 4: Analysis

Session 5: original research.

Students should design some form of original research appropriate to their topics, but they do not necessarily have to conduct the experiments or surveys they propose. Depending on the appropriateness of the original research proposals, the time involved, and the resources available, you may prefer to omit the actual research or use it as an extension activity.

Session 6: Results (optional)

Session 7: conclusion, session 8: references and writing final draft, student assessment / reflections.

• Observe students’ participation in the initial stages of the Research Paper Scaffold and promptly address any errors or misconceptions about the research process.
• Observe students and provide feedback as they complete each section of the Research Paper Scaffold.
• Provide a safe environment where students will want to take risks in exploring ideas. During collaborative work, offer feedback and guidance to those who need encouragement or require assistance in learning cooperation and tolerance.
• Involve students in using the Research Paper Scoring Rubric for final evaluation of the research paper. Go over this rubric during Session 8, before they write their final drafts.
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Simple Guideline On How To Write A Research Paper For Middle School

As a middle school student writing a research paper there are a few key things you need to know. You need to pick a topic that suits your paper requirements. If you are writing a paper for an English class, you may not be able to get away with writing on the topic of economics, unless otherwise approves by your teacher. The topic you pick must be precise. You won't get very far if you pick a large topic for a small paper.

For example, writing a history research paper on the effects of slavery on the southern states is far too broad a topic, especially for a research paper that is between two and five pages. Instead, narrow down your topic to something a bit more manageable.

After you have your topic, you should follow these rules for writing the research paper:

• The first is writing a thesis statement. The thesis explains what your paper is about and what problem you are trying to answer. You want the thesis statement to be the last sentence of your introduction.
• The introduction is the first paragraph which gives the reader background. So if your topic relates to slavery then your introduction might include a sentence about what slavery was in America and how long it lasted.
• After the introduction you want the body of the research paper. The body should be three to five paragraphs based on your requirements. Each paragraph should have a specific point made followed by evidence to back up the point. That means you need to find three points to support your thesis statement. If, for example, your thesis is that cell phones should not be permitted in classrooms, each paragraph in your body should explain one point why not with evidence to back it up.
• And speaking of evidence, what is it really? Evidence is data or facts or quotes from professionals that you include to support your statement. If you claim that teenagers cheat with their cell phones in class, you should find a quote or statistic related to the number of students who cheat.

Once you are done you need to conclude your paper with the concluding paragraph. This paragraph is where you mention your thesis statement again in a different way and mention your main reasons again. By using these tips you will be well on your way to completing a great research paper for whichever class you are in.

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MIDDLE SCHOOL MATTERS

High-quality support and resources for the middle grades

Middle School Matters Field Guide

Who should use the field guide? The field guide can be used by all middle grades educators, including principals, administrators, counselors, instructional coaches, teachers, and interventionists.

What content areas and grade levels are addressed? The field guide principles and practices apply to all content areas (including science and social studies) and apply to 6th, 7th, and 8th graders (including students who are learning English).

How do educators use the field guide? The field guide contains examples and illustrations for each recommended practice to help educators understand and then implement these practices in their classrooms and schools. Additional implementation support can be found in our Instructional Toolkits.

If you have any questions about the field guide or how to use it, please contact us at [email protected]

Acknowledgements The George W. Bush Institute and The Meadows Center for Preventing Educational Risk would like to thank the many individuals who have contributed to the development of the first field guide, which provided the basis for this updated, second edition.

Complete Field Guide

• Cover and Introduction
• Complete Chapter 1: Research-Based Instruction
• Reading and Reading Interventions
• Writing and Writing Interventions
• Mathematics and Mathematics Interventions
• Cognitive Science and Advanced Reasoning
• Complete Chapter 2: Students Supports that Enhance Learning
• Dropout Prevention
• School Climate and Culture
• Student Behavior and Motivation
• Extended Learning Time
• Complete Chapter 3: Informed Decision Making (Performance Management)
• Appendix Summary

Research-Based Practices That Matter booklet (Outline of Field Guide principles and practices) -->

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How to Teach Middle School Students to Write Research Papers

Related articles, step-by-step explanation of how to write a research paper for elementary students, the types of outlining for writing research papers, how to write a college critical thinking essay.

• Teaching Bibliography Format for 5th Graders
• How to Write a College Expository Essay

Middle school students are in the unique position of transitioning from writing simple, elementary-level pieces to fully developed essays. That said, the research paper is the most complex form of academic writing, and you'll need to walk them through the entire writing process. You should also stress how important it is that they treat writing as a process, so they understand that prewriting and revision are just as crucial as writing their actual drafts.

The Assignment

The first thing you must do is explain the mode of the essay and all its accompanying rules and procedures. Each student will use evidence to support a specific claim, which is known as a thesis. Also detail the parameters of the assignment: the expected length of the paper, its due date -- including due dates for outlines, first drafts, etc. -- as well as how many outside sources each student will have to cite. Then, discuss the format for the essay, which will probably be MLA format. If possible, distribute printouts that contain all of this information in a neat and organized manner. You can even include a sample paper for later reference.

Prewriting Procedures

Spend at least half the time allotted for the paper on prewriting. Begin with lessons on brainstorming and determining whether students' theses will work for the assignment. Then, move on to conducting research. Explain the differences between primary resources and secondary resources, and how your students can use each to strengthen their essays. Teach them how to use note cards to organize and order their information to best present their arguments. Once their ideas are in place, walk them through the process of outlining. Stress to them that outlines are blueprints for essays, and that a strong outline can reduce stress while drafting and editing.

The Drafting Process

As soon as the students have solid outlines, have them begin their first drafts. Encourage them to stick strictly to their outlines, and to focus on transitioning smoothly from each topic of discussion to the next. Once they've completed first drafts, have students work in groups to read and critique the structure of each others' arguments. Have each student make notes about what was confusing about each essay, and also what he or she found compelling. Have them evaluate introductions, bodies and conclusions. Students can then compile feedback from their peers and see if there are any consistent difficulties with the readings.

Editing and Revision

This final stage provides opportunities for collaborative learning and group work. Once students have made any structural changes to their essays, you can place them again into groups and have them proofread each others' papers. This is also the time when you want to revisit the lesson on formatting: MLA headings, citations and bibliography pages. You can even incorporate a short citation exercise to give them a slight break from the assignment. Assign very short pieces about topics of their choosing. The only requirement is they must use an outside source for the information and cite it properly both in the text and at the end of the piece.

• Common Core State Standards Initiative: English Language Arts Standards: Writing: Grade 7

Christopher Cascio is a memoirist and holds a Master of Fine Arts in creative writing and literature from Southampton Arts at Stony Brook Southampton, and a Bachelor of Arts in English with an emphasis in the rhetoric of fiction from Pennsylvania State University. His literary work has appeared in "The Southampton Review," "Feathertale," "Kalliope" and "The Rose and Thorn Journal."

5 Step Writing Process for Kids

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How to Create a Strong Research Paper: A Guide for Middle School Students

When a middle school student first begins the research paper process, he or she has a lot of writing rules to remember. And if the child has to write an APA and a MLA paper at different times, then there are even more things to remember. Use this guide as this very important foundation is built.

Step to Remember

• Pick a good topic with lots of facts
• Have 2-4 main ideas
• Use academic and credible research
• Read the teacher instructions and follow the teacher instructions
• Bookmark an APA and a MLA website for easy reference
• Learn the difference between a reference page, a works cited, and a bibliography
• Go to any extra help given
• Learn how to do an in-text citation, know the APA and the MLA way
• Write in third person

There are different tips for different styles of papers. You have to know what style your teacher wants. For example, an informative essay is composed much differently than a cause and effect paper. Know your types and ask questions if you are not sure what to do. The layout of the paper matters, too. So follow these formatting tips:

Formatting Tips

• Use size 12 font
• Use a plain font such as Times New Roman or Arial
• Double space
• Write using a formal tone
• Use correct spelling
• Use correct grammar
• Do not use slang or contractions
• Have the length that the teacher required for the paper
• Use the right number and type of sources the teacher asked for such as magazines, interviews, videos, and studies
• Your teacher will want some or all of these items to be submitted
• A rough draft
• A final draft
• Some type of reference sheet
• A possible electronic submission
• A working outline
• Hard copies of all the sources you used and a link to them if they are online
• Supplemental hard copies of materials such as an interview transcript

One of the best ways to create a successful middle school paper is to pick a topic that you like if the teacher gives you the option of selecting your own topic. You will always write a better paper on a subject that you enjoy and have an interest in. Do yourself a favor and pick a topic you love.

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10 Great Research Topics for Middle School Students

Middle school is the perfect time to start exploring the fascinating world of research, especially if you're passionate about STEM and the humanities. Engaging in research projects now not only feeds your curiosity but also develops critical thinking, problem-solving skills, and a love for learning. Whether you're intrigued by the secrets of the universe, the beauty of numbers, or the complexity of robotics, there's a research project that you can pursue to help you build your knowledge. Let's dive into some advanced yet accessible research topics that will challenge you and enhance your academic journey.

1. Program your own robot

What to do:  Start by defining the purpose of your robot. Will it be a pet robot that follows you around, or perhaps a robot that can help carry small items from one room to another? Sketch your design on paper, focusing on what sensors and motors you'll need. For instance, a robot that follows light might need light sensors, while a robot that avoids obstacles will require ultrasonic sensors. Use an Arduino or Raspberry Pi as the brain. You'll need to learn basic programming in Python (for Raspberry Pi) or C++ (for Arduino) to code your robot's behavior.

Tips to get started:  The official websites for Arduino  and Raspberry Pi  offer tutorials for beginners. For more specific projects, such as building a pet robot, search for guides on Instructables  that detail each step from hardware assembly to software programming.

2. Design a solar-powered oven

What to do:  Investigate how solar ovens work and the science behind solar cooking. Your oven can be as simple as a pizza box solar oven or more complex, like a parabolic solar cooker. Key materials include reflective surfaces (aluminum foil), clear plastic wrap to create a greenhouse effect, and black construction paper to absorb heat. Experiment with different shapes and angles to maximize the heat capture and cooking efficiency. Test your oven by trying to cook different foods and measure the temperature achieved and cooking time required.

Tips to get started:  The Solar Cooking  wiki is an excellent resource for finding different solar cooker designs and construction plans. YouTube also has numerous DIY solar oven tutorials. Document your process and results in a project journal, noting any changes in design that lead to improvements in efficiency.

3. Assess the health of a local ecosystem

What to do:  Choose a local natural area, such as a stream, pond, or forest, and plan a series of observations and tests to assess its health. Key activities could include water quality testing (for pH, nitrates, and phosphates), soil testing (for composition and contaminants), and biodiversity surveys (identifying species of plants and animals present). Compile your data to evaluate the ecosystem's health, looking for signs of pollution, habitat destruction, or invasive species.

Tips to get started:  For a comprehensive approach, NOAA’s Global Monitoring Laboratory  provides information on atmospheric and environmental monitoring techniques. Tools like iNaturalist  can assist in species identification, and water and soil testing kits are available from science education suppliers.

4. Develop an educational app

What to do:  Identify a gap in educational resources that your app could fill. Perhaps you noticed that students struggle with a particular math concept, or there's a lack of engaging resources for learning a foreign language. Outline your app’s features, design the user interface, and plan the content it will deliver. Use MIT App Inventor  for a drag-and-drop development experience, or Scratch  for a game-like educational app. Test your app with classmates or family members, and use their feedback for improvements.

Tips to get started:  Both MIT App Inventor  and Scratch  provide tutorials and community forums where you can learn from others’ projects. Begin with a simple prototype, focusing on one core feature, and expand from there.

5. Model rocketry: design, build, and launch!

What to do:  Dive into the basics of rocket science by designing your own model rocket. Understand the principles of thrust, aerodynamics, and stability as you plan your rocket. Materials can range from simple kits available online to homemade components for the body, fins, and nose cone. Educate yourself on the proper engine selection for your design and the recovery system to ensure your rocket returns safely. Conduct a launch in a safe, open area, following all safety guidelines.

Tips to get started:  The National Association of Rocketry  is a treasure trove of information on model rocket safety, design, and launch procedures. For beginners, consider starting with a kit from Estes Rockets , which includes all necessary components and instructions.

6. Create a wearable electronic device

What to do:  Envision a wearable device that solves a problem or enhances an aspect of daily life. It could be a smart bracelet that reminds you to stay hydrated or a hat with integrated LEDs for nighttime visibility. Sketch your design, listing the components you'll need, such as LEDs, sensors, a power source, and a microcontroller like the Adafruit Flora or Gemma. Plan your circuit, sew or assemble your device, and program it to function as intended.

Tips to get started:   Adafruit’s Wearables  section offers guides and tutorials for numerous wearable projects, including coding and circuit design. Start with a simple project to familiarize yourself with electronics and sewing conductive thread before moving on to more complex designs.

7. Explore the science of slime and non-Newtonian fluids

What to do:  Conduct experiments to understand how the composition of slime affects its properties. Create a standard slime recipe using glue, borax (or contact lens solution as a safer alternative), and water. Alter the recipe by varying the amounts of each ingredient or adding additives like cornstarch, shaving cream, or thermochromic pigment. Test how each variation affects the slime’s viscosity, stretchiness, and reaction to pressure.

Tips to get started:  The Science Bob  website offers a basic slime recipe and the science behind it. Document each experiment carefully, noting the recipe used and the observed properties. This will help you understand the science behind non-Newtonian fluids.

8. Extract DNA at home

What to do:  Use common household items to extract DNA from fruits or vegetables, like strawberries or onions. The basic process involves mashing the fruit, adding a mixture of water, salt, and dish soap to break down cell membranes, and then using cold alcohol to precipitate the DNA out of the solution. Observe and analyze the DNA strands.

Tips to get started:  Detailed instructions and the science explanation are available at the Genetic Science Learning Center . This project offers a tangible glimpse into the molecular basis of life and can be a springboard to more complex biotechnology experiments.

9. Investigate the efficiency of different types of solar cells

What to do:  Compare the efficiency of various solar panels, such as monocrystalline, polycrystalline, and thin-film. Design an experiment to measure the electrical output of each type under identical lighting conditions, using a multimeter to record voltage and current. Analyze how factors like angle of incidence, light intensity, and temperature affect their performance.

Tips to get started:  Introductory resources on solar energy and experiments can be found at the Energy.gov  website. Consider purchasing small solar panels of different types from electronics stores or online suppliers. Ensure that all tests are conducted under controlled conditions for accurate comparisons.

10. Study ocean acidification and its effects on marine life

What to do:  Simulate the effects of ocean acidification on marine organisms in a controlled experiment. Use vinegar to lower the pH of water in a tank and observe its impact on calcium carbonate shells or skeletons, such as seashells or coral fragments. Monitor and record changes over time, researching how acidification affects the ability of these organisms to maintain their shells and skeletons.

Tips to get started:   NOAA’s Ocean Acidification Program  offers educational materials and experiment ideas. For a simpler version of this experiment, see instructions for observing the effects of acidified water on eggshells, which are similar in composition to marine shells, at educational websites like Science Buddies .

By pursuing these projects, you will not only gain a deeper understanding of STEM principles but also develop invaluable skills in research, design, and critical analysis. These projects will teach you how to question, experiment, and innovate, laying the groundwork for future scientific inquiries and discoveries.

One other option – Lumiere’s Junior Explorer Program

The Lumiere Junior Explorer Program is a program for middle school students to work one-on-one with a mentor to explore their academic interests and build a project they are passionate about .  Our mentors are scholars from top research universities such as Harvard, MIT, Stanford, Yale, Duke and LSE.

The program was founded by a Harvard & Oxford PhD who met as undergraduates at Harvard. The program is rigorous and fully virtual. We offer need based financial aid for students who qualify. You can find the application in the brochure ! 

To learn more, you can reach out to our Head of Growth, Khushi Malde, at [email protected] or go to our website .

Multiple rolling deadlines for JEP cohorts across the year, you can apply using this application link ! If you'd like to take a look at the cohorts + deadlines for 2024, you can refer to this page!

Stephen is one of the founders of Lumiere and a Harvard College graduate. He founded Lumiere as a PhD student at Harvard Business School. Lumiere is a selective research program where students work 1-1 with a research mentor to develop an independent research paper.

• middle school students

ChatGPT for Teachers

Trauma-informed practices in schools, teacher well-being, cultivating diversity, equity, & inclusion, integrating technology in the classroom, social-emotional development, covid-19 resources, invest in resilience: summer toolkit, civics & resilience, all toolkits, degree programs, trauma-informed professional development, teacher licensure & certification, how to become - career information, classroom management, instructional design, lifestyle & self-care, online higher ed teaching, current events, how to help middle school students develop research skills.

As the research skills you teach middle school students can last them all their lives, it’s essential to help them develop good habits early in their school careers.

Research skills are useful in nearly every subject, whether it’s English, math, social studies or science, and they will continue to pay off for students every day of their schooling. Understanding the most important research skills that middle school students need will help reach these kids and make a long-term difference.

The research process

It is important for every student to understand that research is actually a process rather than something that happens naturally. The best researchers develop a process that allows them to fully comprehend the ideas they are researching and also turn the data into information that is usable for whatever the end purpose may be. Here is an example of a research process that you may consider using when teaching research skills in your middle school classroom:

• Form a question : Research should be targeted; develop a question you want to answer before progressing any further.
• Decide on resources : Not every resource is good for every question/problem. Identify the resources that will work best for you.
• Gather raw data : First, gather information in its rawest form; do not attempt to make sense of it at this point.
• Sort the data : After you have the information in front of you, decide what is important to you and how you will use it. Not all data will be reliable or worthwhile.
• Process information : Turn the data into usable information. This processing step may take longer than the rest combined. This is where you really see your data shape into something exciting.
• Create a final piece : This is where you would write a research paper, create a project or build a graph or other visual piece with your information. This may or may not be a formal document.
• Evaluate : Look back on the process. Where did you experience success and failure? Did you find an answer to your question?

This process can be adjusted to suit the needs of your particular classroom or the project you are working on. Just remember that the goal is not only to find the data for this particular project, but to teach your students research skills that will help them in the long run.

Research is a very important part of the learning process as well as being useful in real-life once the student graduates. Middle school is a great time to develop these skills as many high school teachers expect that students already have this knowledge.

Students who are well-prepared as researchers will be able to handle nearly any assignment that comes their way. Finding new ways to teach research skills to middle school students need will be a challenge, but the results are well worth it as you see your students succeed in your classroom and set the stage for further success throughout their schooling experience.

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• Building Math Skills in High School Students
• How to Help High School Students with Career Research
• Five Free Websites for Students to Build Research Skills
• Homework in Middle School: Building a Foundation for Study Skills
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iRubric: Middle School Research Paper rubric

• Research paper - emphasis on relevance of research
• Presentation

Looking in Detail at a Research Paper Grading Rubric for Middle School

A research paper grading rubric middle school is important as it guides the markers on the final marks or score to award. As a student, it lets you know how to write the paper if you want to score high grades. The exact research paper rubric for middle school may vary from one institution to the other but the example below provides useful source and guide on how it should ideally be –

• Introduction: The top grade paper has exceptional introduction which grabs the attention and interest of the reader. The second grade paper may have introduction which can be described as ‘proficient’, as it states the topic well. The third grade paper has introduction that states the topic well but is not interesting. The lowest grade paper has a weak introduction, or none to the topic.
• Thesis: A top grade paper will thesis that is exceptionally well-developed, arguable, clear and definitive statement. A paper immediately below the top grade will have thesis that is clear and provides arguable statement of position. An average paper will have thesis that is somehow clear and very arguable. A poorly written paper is one in which the purpose of the paper is not very clear, and the thesis may be missing or weak.
• Support of Thesis: In the top grade middle school paper, the support for thesis is relevant, consistent and critical, and makes connections between the evidence and the thesis. For paper just below the top grade, it makes consistent connections between the evidence and the thesis. In average grade paper, it makes some connections between the evidence and the thesis. The lowest paper in this category only makes limited connections, or none at all, between the evidence and the thesis.
• Organization and Development of Thesis: A top grade paper in this category is exceptionally logical, mature, clear, and gives thorough and clear development of thesis. It provides excellent transitions both between and within the paragraphs. In the next grade, the paper provides clear and logical order which provides support for the thesis and has good transitions both between and within the paragraphs. Next, he paper is somewhat clear, and has a logical development with only the basic transitions both between and within the paragraphs. Lowest in this category, the paper lacks development of ideas and has weak and probably, no transitions exist between and also within the paragraphs.
• Conclusion: In top grade paper, the conclusion is an excellent summary of the topic and has concluding ideas of impact to the reader. The next grade paper provides good summary of the topic and has clear concluding ideas. For paper below the top two grades, the conclusion is a basic summary of the topic and has some final concluding ideas. Lowest in this category is that has no conclusion, or it contains irrelevant information, or introduces new ideas.

This is a typical research paper rubric middle school and can be used in the grading of most papers. Each category may be out of 20. With the top paper in the category getting between 16 and 20; a paper below the top grade getting between 11 and 15; average paper getting between 6 and 10; and a low grade paper getting between 0 and 5.

• Paper writing service

How to Write a Research Paper as a High School Student

By Carly Taylor

Senior at Stanford University

6 minute read

Read our guide to learn why you should write a research paper and how to do so, from choosing the right topic to outlining and structuring your argument.

What is a research paper?

A research paper poses an answer to a specific question and defends that answer using academic sources, data, and critical reasoning. Writing a research paper is an excellent way to hone your focus during a research project , synthesize what you’re learning, and explain why your work matters to a broader audience of scholars in your field.

The types of sources and evidence you’ll see used in a research paper can vary widely based on its field of study. A history research paper might examine primary sources like journals and newspaper articles to draw conclusions about the culture of a specific time and place, whereas a biology research paper might analyze data from different published experiments and use textbook explanations of cellular pathways to identify a potential marker for breast cancer.

However, researchers across disciplines must identify and analyze credible sources, formulate a specific research question, generate a clear thesis statement, and organize their ideas in a cohesive manner to support their argument. Read on to learn how this process works and how to get started writing your own research paper.

How do I choose my topic?

Tap into your passions.

A research paper is your chance to explore what genuinely interests you and combine ideas in novel ways. So don’t choose a subject that simply sounds impressive or blindly follow what someone else wants you to do – choose something you’re really passionate about! You should be able to enjoy reading for hours and hours about your topic and feel enthusiastic about synthesizing and sharing what you learn.

We've created these helpful resources to inspire you to think about your own passion project . Polygence also offers a passion exploration experience where you can dive deep into three potential areas of study with expert mentors from those fields.

Ask a difficult question

In the traditional classroom, top students are expected to always know the answers to the questions the teacher asks. But a research paper is YOUR chance to pose a big question that no one has answered yet, and figure out how to make a contribution to answering that question. So don’t be afraid if you have no idea how to answer your question at the start of the research process — this will help you maintain a motivational sense of discovery as you dive deeper into your research. If you need inspiration, explore our database of research project ideas .

Be as specific as possible

It’s essential to be reasonable about what you can accomplish in one paper and narrow your focus down to an issue you can thoroughly address. For example, if you’re interested in the effects of invasive species on ecosystems, it’s best to focus on one invasive species and one ecosystem, such as iguanas in South Florida , or one survival mechanism, such as supercolonies in invasive ant species . If you can, get hands on with your project.

You should approach your paper with the mindset of becoming an expert in this topic. Narrowing your focus will help you achieve this goal without getting lost in the weeds and overwhelming yourself.

Would you like to write your own research paper?

Polygence mentors can help you every step of the way in writing and showcasing your research paper

How do I prepare to write a research paper?

Conduct preliminary research.

Before you dive into writing your research paper, conduct a literature review to see what’s already known about your topic. This can help you find your niche within the existing body of research and formulate your question. For example, Polygence student Jasmita found that researchers had studied the effects of background music on student test performance, but they had not taken into account the effect of a student’s familiarity with the music being played, so she decided to pose this new question in her research paper.

Pro tip: It’s a good idea to skim articles in order to decide whether they’re relevant enough to your research interest before committing to reading them in full. This can help you spend as much time as possible with the sources you’ll actually cite in your paper.

Skimming articles will help you gain a broad-strokes view of the different pockets of existing knowledge in your field and identify the most potentially useful sources. Reading articles in full will allow you to accumulate specific evidence related to your research question and begin to formulate an answer to it.

Draft a thesis statement

Your thesis statement is your succinctly-stated answer to the question you’re posing, which you’ll make your case for in the body of the paper. For example, if you’re studying the effect of K-pop on eating disorders and body image in teenagers of different races, your thesis may be that Asian teenagers who are exposed to K-pop videos experience more negative effects on their body image than Caucasian teenagers.

Pro Tip: It’s okay to refine your thesis as you continue to learn more throughout your research and writing process! A preliminary thesis will help you come up with a structure for presenting your argument, but you should absolutely change your thesis if new information you uncover changes your perspective or adds nuance to it.

Create an outline

An outline is a tool for sketching out the structure of your paper by organizing your points broadly into subheadings and more finely into individual paragraphs. Try putting your thesis at the top of your outline, then brainstorm all the points you need to convey in order to support your thesis.

Pro Tip : Your outline is just a jumping-off point – it will evolve as you gain greater clarity on your argument through your writing and continued research. Sometimes, it takes several iterations of outlining, then writing, then re-outlining, then rewriting in order to find the best structure for your paper.

What are some key tips when writing?

Introduction.

Your introduction should move the reader from your broad area of interest into your specific area of focus for the paper. It generally takes the form of one to two paragraphs that build to your thesis statement and give the reader an idea of the broad argumentative structure of your paper. After reading your introduction, your reader should know what claim you’re going to present and what kinds of evidence you’ll analyze to support it.

Topic sentences

Writing crystal clear topic sentences is a crucial aspect of a successful research paper. A topic sentence is like the thesis statement of a particular paragraph – it should clearly state the point that the paragraph will make. Writing focused topic sentences will help you remain focused while writing your paragraphs and will ensure that the reader can clearly grasp the function of each paragraph in the paper’s overall structure.

Transitions

Sophisticated research papers move beyond tacking on simple transitional phrases such as “Secondly” or “Moreover” to the start of each new paragraph. Instead, each paragraph flows naturally into the next one, with the connection between each idea made very clear. Try using specifically-crafted transitional phrases rather than stock phrases to move from one point to the next that will make your paper as cohesive as possible.

In her research paper on Pakistani youth in the U.S. , Polygence student Iba used the following specifically-crafted transition to move between two paragraphs: “Although the struggles of digital ethnography limited some data collection, there are also many advantages of digital data collection.” This sentence provides the logical link between the discussion of the limitations of digital ethnography from the prior paragraph and the upcoming discussion of this techniques’ advantages in this paragraph.

What is a research paper conclusion?

Your conclusion can have several functions:

To drive home your thesis and summarize your argument

To emphasize the broader significance of your findings and answer the “so what” question

To point out some questions raised by your thesis and/or opportunities for further research

Your conclusion can take on all three of these tasks or just one, depending on what you feel your paper is still lacking up to this point.

How do I cite my sources?

Last but not least, giving credit to your sources is extremely important. There are many different citation formats such as MLA, APA, and Chicago style. Make sure you know which one is standard in your field of interest by researching online or consulting an expert.

You have several options for keeping track of your bibliography:

Use a notebook to record the relevant information from each of your sources: title, author, date of publication, journal name, page numbers, etc.

Create a folder on your computer where you can store your electronic sources

Use an online bibliography creator such as Zotero, Easybib, or Noodletools to track sources and generate citations

You can read research papers by Polygence students under our Projects tab. You can also explore other opportunities for high school research .

If you’re interested in finding an expert mentor to guide you through the process of writing your own independent research paper, consider applying to be a Polygence scholar today!

Your research paper help even you to earn college credit , get published in an academic journal , contribute to your application for college , improve your college admissions chances !

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Interested in doing an exciting research project? Click below to get matched with one of our expert mentors!

Cultural Relativity and Acceptance of Embryonic Stem Cell Research

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Main Article Content

There is a debate about the ethical implications of using human embryos in stem cell research, which can be influenced by cultural, moral, and social values. This paper argues for an adaptable framework to accommodate diverse cultural and religious perspectives. By using an adaptive ethics model, research protections can reflect various populations and foster growth in stem cell research possibilities.

INTRODUCTION

Stem cell research combines biology, medicine, and technology, promising to alter health care and the understanding of human development. Yet, ethical contention exists because of individuals’ perceptions of using human embryos based on their various cultural, moral, and social values. While these disagreements concerning policy, use, and general acceptance have prompted the development of an international ethics policy, such a uniform approach can overlook the nuanced ethical landscapes between cultures. With diverse viewpoints in public health, a single global policy, especially one reflecting Western ethics or the ethics prevalent in high-income countries, is impractical. This paper argues for a culturally sensitive, adaptable framework for the use of embryonic stem cells. Stem cell policy should accommodate varying ethical viewpoints and promote an effective global dialogue. With an extension of an ethics model that can adapt to various cultures, we recommend localized guidelines that reflect the moral views of the people those guidelines serve.

Stem cells, characterized by their unique ability to differentiate into various cell types, enable the repair or replacement of damaged tissues. Two primary types of stem cells are somatic stem cells (adult stem cells) and embryonic stem cells. Adult stem cells exist in developed tissues and maintain the body’s repair processes. [1] Embryonic stem cells (ESC) are remarkably pluripotent or versatile, making them valuable in research. [2] However, the use of ESCs has sparked ethics debates. Considering the potential of embryonic stem cells, research guidelines are essential. The International Society for Stem Cell Research (ISSCR) provides international stem cell research guidelines. They call for “public conversations touching on the scientific significance as well as the societal and ethical issues raised by ESC research.” [3] The ISSCR also publishes updates about culturing human embryos 14 days post fertilization, suggesting local policies and regulations should continue to evolve as ESC research develops. [4]  Like the ISSCR, which calls for local law and policy to adapt to developing stem cell research given cultural acceptance, this paper highlights the importance of local social factors such as religion and culture.

I.     Global Cultural Perspective of Embryonic Stem Cells

Views on ESCs vary throughout the world. Some countries readily embrace stem cell research and therapies, while others have stricter regulations due to ethical concerns surrounding embryonic stem cells and when an embryo becomes entitled to moral consideration. The philosophical issue of when the “someone” begins to be a human after fertilization, in the morally relevant sense, [5] impacts when an embryo becomes not just worthy of protection but morally entitled to it. The process of creating embryonic stem cell lines involves the destruction of the embryos for research. [6] Consequently, global engagement in ESC research depends on social-cultural acceptability.

a.     US and Rights-Based Cultures

In the United States, attitudes toward stem cell therapies are diverse. The ethics and social approaches, which value individualism, [7] trigger debates regarding the destruction of human embryos, creating a complex regulatory environment. For example, the 1996 Dickey-Wicker Amendment prohibited federal funding for the creation of embryos for research and the destruction of embryos for “more than allowed for research on fetuses in utero.” [8] Following suit, in 2001, the Bush Administration heavily restricted stem cell lines for research. However, the Stem Cell Research Enhancement Act of 2005 was proposed to help develop ESC research but was ultimately vetoed. [9] Under the Obama administration, in 2009, an executive order lifted restrictions allowing for more development in this field. [10] The flux of research capacity and funding parallels the different cultural perceptions of human dignity of the embryo and how it is socially presented within the country’s research culture. [11]

b.     Ubuntu and Collective Cultures

African bioethics differs from Western individualism because of the different traditions and values. African traditions, as described by individuals from South Africa and supported by some studies in other African countries, including Ghana and Kenya, follow the African moral philosophies of Ubuntu or Botho and Ukama , which “advocates for a form of wholeness that comes through one’s relationship and connectedness with other people in the society,” [12] making autonomy a socially collective concept. In this context, for the community to act autonomously, individuals would come together to decide what is best for the collective. Thus, stem cell research would require examining the value of the research to society as a whole and the use of the embryos as a collective societal resource. If society views the source as part of the collective whole, and opposes using stem cells, compromising the cultural values to pursue research may cause social detachment and stunt research growth. [13] Based on local culture and moral philosophy, the permissibility of stem cell research depends on how embryo, stem cell, and cell line therapies relate to the community as a whole. Ubuntu is the expression of humanness, with the person’s identity drawn from the “’I am because we are’” value. [14] The decision in a collectivistic culture becomes one born of cultural context, and individual decisions give deference to others in the society.

Consent differs in cultures where thought and moral philosophy are based on a collective paradigm. So, applying Western bioethical concepts is unrealistic. For one, Africa is a diverse continent with many countries with different belief systems, access to health care, and reliance on traditional or Western medicines. Where traditional medicine is the primary treatment, the “’restrictive focus on biomedically-related bioethics’” [is] problematic in African contexts because it neglects bioethical issues raised by traditional systems.” [15] No single approach applies in all areas or contexts. Rather than evaluating the permissibility of ESC research according to Western concepts such as the four principles approach, different ethics approaches should prevail.

Another consideration is the socio-economic standing of countries. In parts of South Africa, researchers have not focused heavily on contributing to the stem cell discourse, either because it is not considered health care or a health science priority or because resources are unavailable. [16] Each country’s priorities differ given different social, political, and economic factors. In South Africa, for instance, areas such as maternal mortality, non-communicable diseases, telemedicine, and the strength of health systems need improvement and require more focus [17] Stem cell research could benefit the population, but it also could divert resources from basic medical care. Researchers in South Africa adhere to the National Health Act and Medicines Control Act in South Africa and international guidelines; however, the Act is not strictly enforced, and there is no clear legislation for research conduct or ethical guidelines. [18]

Some parts of Africa condemn stem cell research. For example, 98.2 percent of the Tunisian population is Muslim. [19] Tunisia does not permit stem cell research because of moral conflict with a Fatwa. Religion heavily saturates the regulation and direction of research. [20] Stem cell use became permissible for reproductive purposes only recently, with tight restrictions preventing cells from being used in any research other than procedures concerning ART/IVF.  Their use is conditioned on consent, and available only to married couples. [21] The community's receptiveness to stem cell research depends on including communitarian African ethics.

c.     Asia

Some Asian countries also have a collective model of ethics and decision making. [22] In China, the ethics model promotes a sincere respect for life or human dignity, [23] based on protective medicine. This model, influenced by Traditional Chinese Medicine (TCM), [24] recognizes Qi as the vital energy delivered via the meridians of the body; it connects illness to body systems, the body’s entire constitution, and the universe for a holistic bond of nature, health, and quality of life. [25] Following a protective ethics model, and traditional customs of wholeness, investment in stem cell research is heavily desired for its applications in regenerative therapies, disease modeling, and protective medicines. In a survey of medical students and healthcare practitioners, 30.8 percent considered stem cell research morally unacceptable while 63.5 percent accepted medical research using human embryonic stem cells. Of these individuals, 89.9 percent supported increased funding for stem cell research. [26] The scientific community might not reflect the overall population. From 1997 to 2019, China spent a total of $576 million (USD) on stem cell research at 8,050 stem cell programs, increased published presence from 0.6 percent to 14.01 percent of total global stem cell publications as of 2014, and made significant strides in cell-based therapies for various medical conditions. [27] However, while China has made substantial investments in stem cell research and achieved notable progress in clinical applications, concerns linger regarding ethical oversight and transparency. [28] For example, the China Biosecurity Law, promoted by the National Health Commission and China Hospital Association, attempted to mitigate risks by introducing an institutional review board (IRB) in the regulatory bodies. 5800 IRBs registered with the Chinese Clinical Trial Registry since 2021. [29] However, issues still need to be addressed in implementing effective IRB review and approval procedures.

The substantial government funding and focus on scientific advancement have sometimes overshadowed considerations of regional cultures, ethnic minorities, and individual perspectives, particularly evident during the one-child policy era. As government policy adapts to promote public stability, such as the change from the one-child to the two-child policy, [30] research ethics should also adapt to ensure respect for the values of its represented peoples.

Japan is also relatively supportive of stem cell research and therapies. Japan has a more transparent regulatory framework, allowing for faster approval of regenerative medicine products, which has led to several advanced clinical trials and therapies. [31] South Korea is also actively engaged in stem cell research and has a history of breakthroughs in cloning and embryonic stem cells. [32] However, the field is controversial, and there are issues of scientific integrity. For example, the Korean FDA fast-tracked products for approval, [33] and in another instance, the oocyte source was unclear and possibly violated ethical standards. [34] Trust is important in research, as it builds collaborative foundations between colleagues, trial participant comfort, open-mindedness for complicated and sensitive discussions, and supports regulatory procedures for stakeholders. There is a need to respect the culture’s interest, engagement, and for research and clinical trials to be transparent and have ethical oversight to promote global research discourse and trust.

d.     Middle East

Countries in the Middle East have varying degrees of acceptance of or restrictions to policies related to using embryonic stem cells due to cultural and religious influences. Saudi Arabia has made significant contributions to stem cell research, and conducts research based on international guidelines for ethical conduct and under strict adherence to guidelines in accordance with Islamic principles. Specifically, the Saudi government and people require ESC research to adhere to Sharia law. In addition to umbilical and placental stem cells, [35] Saudi Arabia permits the use of embryonic stem cells as long as they come from miscarriages, therapeutic abortions permissible by Sharia law, or are left over from in vitro fertilization and donated to research. [36] Laws and ethical guidelines for stem cell research allow the development of research institutions such as the King Abdullah International Medical Research Center, which has a cord blood bank and a stem cell registry with nearly 10,000 donors. [37] Such volume and acceptance are due to the ethical ‘permissibility’ of the donor sources, which do not conflict with religious pillars. However, some researchers err on the side of caution, choosing not to use embryos or fetal tissue as they feel it is unethical to do so. [38]

Jordan has a positive research ethics culture. [39] However, there is a significant issue of lack of trust in researchers, with 45.23 percent (38.66 percent agreeing and 6.57 percent strongly agreeing) of Jordanians holding a low level of trust in researchers, compared to 81.34 percent of Jordanians agreeing that they feel safe to participate in a research trial. [40] Safety testifies to the feeling of confidence that adequate measures are in place to protect participants from harm, whereas trust in researchers could represent the confidence in researchers to act in the participants’ best interests, adhere to ethical guidelines, provide accurate information, and respect participants’ rights and dignity. One method to improve trust would be to address communication issues relevant to ESC. Legislation surrounding stem cell research has adopted specific language, especially concerning clarification “between ‘stem cells’ and ‘embryonic stem cells’” in translation. [41] Furthermore, legislation “mandates the creation of a national committee… laying out specific regulations for stem-cell banking in accordance with international standards.” [42] This broad regulation opens the door for future global engagement and maintains transparency. However, these regulations may also constrain the influence of research direction, pace, and accessibility of research outcomes.

e.     Europe

In the European Union (EU), ethics is also principle-based, but the principles of autonomy, dignity, integrity, and vulnerability are interconnected. [43] As such, the opportunity for cohesion and concessions between individuals’ thoughts and ideals allows for a more adaptable ethics model due to the flexible principles that relate to the human experience The EU has put forth a framework in its Convention for the Protection of Human Rights and Dignity of the Human Being allowing member states to take different approaches. Each European state applies these principles to its specific conventions, leading to or reflecting different acceptance levels of stem cell research. [44]

For example, in Germany, Lebenzusammenhang , or the coherence of life, references integrity in the unity of human culture. Namely, the personal sphere “should not be subject to external intervention.” [45]  Stem cell interventions could affect this concept of bodily completeness, leading to heavy restrictions. Under the Grundgesetz, human dignity and the right to life with physical integrity are paramount. [46] The Embryo Protection Act of 1991 made producing cell lines illegal. Cell lines can be imported if approved by the Central Ethics Commission for Stem Cell Research only if they were derived before May 2007. [47] Stem cell research respects the integrity of life for the embryo with heavy specifications and intense oversight. This is vastly different in Finland, where the regulatory bodies find research more permissible in IVF excess, but only up to 14 days after fertilization. [48] Spain’s approach differs still, with a comprehensive regulatory framework. [49] Thus, research regulation can be culture-specific due to variations in applied principles. Diverse cultures call for various approaches to ethical permissibility. [50] Only an adaptive-deliberative model can address the cultural constructions of self and achieve positive, culturally sensitive stem cell research practices. [51]

II.     Religious Perspectives on ESC

Embryonic stem cell sources are the main consideration within religious contexts. While individuals may not regard their own religious texts as authoritative or factual, religion can shape their foundations or perspectives.

The Qur'an states:

“And indeed We created man from a quintessence of clay. Then We placed within him a small quantity of nutfa (sperm to fertilize) in a safe place. Then We have fashioned the nutfa into an ‘alaqa (clinging clot or cell cluster), then We developed the ‘alaqa into mudgha (a lump of flesh), and We made mudgha into bones, and clothed the bones with flesh, then We brought it into being as a new creation. So Blessed is Allah, the Best of Creators.” [52]

Many scholars of Islam estimate the time of soul installment, marked by the angel breathing in the soul to bring the individual into creation, as 120 days from conception. [53] Personhood begins at this point, and the value of life would prohibit research or experimentation that could harm the individual. If the fetus is more than 120 days old, the time ensoulment is interpreted to occur according to Islamic law, abortion is no longer permissible. [54] There are a few opposing opinions about early embryos in Islamic traditions. According to some Islamic theologians, there is no ensoulment of the early embryo, which is the source of stem cells for ESC research. [55]

In Buddhism, the stance on stem cell research is not settled. The main tenets, the prohibition against harming or destroying others (ahimsa) and the pursuit of knowledge (prajña) and compassion (karuna), leave Buddhist scholars and communities divided. [56] Some scholars argue stem cell research is in accordance with the Buddhist tenet of seeking knowledge and ending human suffering. Others feel it violates the principle of not harming others. Finding the balance between these two points relies on the karmic burden of Buddhist morality. In trying to prevent ahimsa towards the embryo, Buddhist scholars suggest that to comply with Buddhist tenets, research cannot be done as the embryo has personhood at the moment of conception and would reincarnate immediately, harming the individual's ability to build their karmic burden. [57] On the other hand, the Bodhisattvas, those considered to be on the path to enlightenment or Nirvana, have given organs and flesh to others to help alleviate grieving and to benefit all. [58] Acceptance varies on applied beliefs and interpretations.

Catholicism does not support embryonic stem cell research, as it entails creation or destruction of human embryos. This destruction conflicts with the belief in the sanctity of life. For example, in the Old Testament, Genesis describes humanity as being created in God’s image and multiplying on the Earth, referencing the sacred rights to human conception and the purpose of development and life. In the Ten Commandments, the tenet that one should not kill has numerous interpretations where killing could mean murder or shedding of the sanctity of life, demonstrating the high value of human personhood. In other books, the theological conception of when life begins is interpreted as in utero, [59] highlighting the inviolability of life and its formation in vivo to make a religious point for accepting such research as relatively limited, if at all. [60] The Vatican has released ethical directives to help apply a theological basis to modern-day conflicts. The Magisterium of the Church states that “unless there is a moral certainty of not causing harm,” experimentation on fetuses, fertilized cells, stem cells, or embryos constitutes a crime. [61] Such procedures would not respect the human person who exists at these stages, according to Catholicism. Damages to the embryo are considered gravely immoral and illicit. [62] Although the Catholic Church officially opposes abortion, surveys demonstrate that many Catholic people hold pro-choice views, whether due to the context of conception, stage of pregnancy, threat to the mother’s life, or for other reasons, demonstrating that practicing members can also accept some but not all tenets. [63]

Some major Jewish denominations, such as the Reform, Conservative, and Reconstructionist movements, are open to supporting ESC use or research as long as it is for saving a life. [64] Within Judaism, the Talmud, or study, gives personhood to the child at birth and emphasizes that life does not begin at conception: [65]

“If she is found pregnant, until the fortieth day it is mere fluid,” [66]

Whereas most religions prioritize the status of human embryos, the Halakah (Jewish religious law) states that to save one life, most other religious laws can be ignored because it is in pursuit of preservation. [67] Stem cell research is accepted due to application of these religious laws.

We recognize that all religions contain subsets and sects. The variety of environmental and cultural differences within religious groups requires further analysis to respect the flexibility of religious thoughts and practices. We make no presumptions that all cultures require notions of autonomy or morality as under the common morality theory , which asserts a set of universal moral norms that all individuals share provides moral reasoning and guides ethical decisions. [68] We only wish to show that the interaction with morality varies between cultures and countries.

III.     A Flexible Ethical Approach

The plurality of different moral approaches described above demonstrates that there can be no universally acceptable uniform law for ESC on a global scale. Instead of developing one standard, flexible ethical applications must be continued. We recommend local guidelines that incorporate important cultural and ethical priorities.

While the Declaration of Helsinki is more relevant to people in clinical trials receiving ESC products, in keeping with the tradition of protections for research subjects, consent of the donor is an ethical requirement for ESC donation in many jurisdictions including the US, Canada, and Europe. [69] The Declaration of Helsinki provides a reference point for regulatory standards and could potentially be used as a universal baseline for obtaining consent prior to gamete or embryo donation.

For instance, in Columbia University’s egg donor program for stem cell research, donors followed standard screening protocols and “underwent counseling sessions that included information as to the purpose of oocyte donation for research, what the oocytes would be used for, the risks and benefits of donation, and process of oocyte stimulation” to ensure transparency for consent. [70] The program helped advance stem cell research and provided clear and safe research methods with paid participants. Though paid participation or covering costs of incidental expenses may not be socially acceptable in every culture or context, [71] and creating embryos for ESC research is illegal in many jurisdictions, Columbia’s program was effective because of the clear and honest communications with donors, IRBs, and related stakeholders.  This example demonstrates that cultural acceptance of scientific research and of the idea that an egg or embryo does not have personhood is likely behind societal acceptance of donating eggs for ESC research. As noted, many countries do not permit the creation of embryos for research.

Proper communication and education regarding the process and purpose of stem cell research may bolster comprehension and garner more acceptance. “Given the sensitive subject material, a complete consent process can support voluntary participation through trust, understanding, and ethical norms from the cultures and morals participants value. This can be hard for researchers entering countries of different socioeconomic stability, with different languages and different societal values. [72]

An adequate moral foundation in medical ethics is derived from the cultural and religious basis that informs knowledge and actions. [73] Understanding local cultural and religious values and their impact on research could help researchers develop humility and promote inclusion.

IV.     Concerns

Some may argue that if researchers all adhere to one ethics standard, protection will be satisfied across all borders, and the global public will trust researchers. However, defining what needs to be protected and how to define such research standards is very specific to the people to which standards are applied. We suggest that applying one uniform guide cannot accurately protect each individual because we all possess our own perceptions and interpretations of social values. [74] Therefore, the issue of not adjusting to the moral pluralism between peoples in applying one standard of ethics can be resolved by building out ethics models that can be adapted to different cultures and religions.

Other concerns include medical tourism, which may promote health inequities. [75] Some countries may develop and approve products derived from ESC research before others, compromising research ethics or drug approval processes. There are also concerns about the sale of unauthorized stem cell treatments, for example, those without FDA approval in the United States. Countries with robust research infrastructures may be tempted to attract medical tourists, and some customers will have false hopes based on aggressive publicity of unproven treatments. [76]

For example, in China, stem cell clinics can market to foreign clients who are not protected under the regulatory regimes. Companies employ a marketing strategy of “ethically friendly” therapies. Specifically, in the case of Beike, China’s leading stem cell tourism company and sprouting network, ethical oversight of administrators or health bureaus at one site has “the unintended consequence of shifting questionable activities to another node in Beike's diffuse network.” [77] In contrast, Jordan is aware of stem cell research’s potential abuse and its own status as a “health-care hub.” Jordan’s expanded regulations include preserving the interests of individuals in clinical trials and banning private companies from ESC research to preserve transparency and the integrity of research practices. [78]

The social priorities of the community are also a concern. The ISSCR explicitly states that guidelines “should be periodically revised to accommodate scientific advances, new challenges, and evolving social priorities.” [79] The adaptable ethics model extends this consideration further by addressing whether research is warranted given the varying degrees of socioeconomic conditions, political stability, and healthcare accessibilities and limitations. An ethical approach would require discussion about resource allocation and appropriate distribution of funds. [80]

While some religions emphasize the sanctity of life from conception, which may lead to public opposition to ESC research, others encourage ESC research due to its potential for healing and alleviating human pain. Many countries have special regulations that balance local views on embryonic personhood, the benefits of research as individual or societal goods, and the protection of human research subjects. To foster understanding and constructive dialogue, global policy frameworks should prioritize the protection of universal human rights, transparency, and informed consent. In addition to these foundational global policies, we recommend tailoring local guidelines to reflect the diverse cultural and religious perspectives of the populations they govern. Ethics models should be adapted to local populations to effectively establish research protections, growth, and possibilities of stem cell research.

For example, in countries with strong beliefs in the moral sanctity of embryos or heavy religious restrictions, an adaptive model can allow for discussion instead of immediate rejection. In countries with limited individual rights and voice in science policy, an adaptive model ensures cultural, moral, and religious views are taken into consideration, thereby building social inclusion. While this ethical consideration by the government may not give a complete voice to every individual, it will help balance policies and maintain the diverse perspectives of those it affects. Embracing an adaptive ethics model of ESC research promotes open-minded dialogue and respect for the importance of human belief and tradition. By actively engaging with cultural and religious values, researchers can better handle disagreements and promote ethical research practices that benefit each society.

This brief exploration of the religious and cultural differences that impact ESC research reveals the nuances of relative ethics and highlights a need for local policymakers to apply a more intense adaptive model.

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[5] Concerning the moral philosophies of stem cell research, our paper does not posit a personal moral stance nor delve into the “when” of human life begins. To read further about the philosophical debate, consider the following sources:

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[7] Socially, at its core, the Western approach to ethics is widely principle-based, autonomy being one of the key factors to ensure a fundamental respect for persons within research. For information regarding autonomy in research, see: Department of Health, Education, and Welfare, & National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research (1978). The Belmont Report. Ethical principles and guidelines for the protection of human subjects of research.; For a more in-depth review of autonomy within the US, see: Beauchamp, T. L., & Childress, J. F. (1994). Principles of Biomedical Ethics . Oxford University Press.

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[9] Stem Cell Research Enhancement Act of 2005, H. R. 810, 109 th Cong. (2001). https://www.govtrack.us/congress/bills/109/hr810/text ; Bush, G. W. (2006, July 19). Message to the House of Representatives . National Archives and Records Administration. https://georgewbush-whitehouse.archives.gov/news/releases/2006/07/20060719-5.html

[10] National Archives and Records Administration. (2009, March 9). Executive order 13505 -- removing barriers to responsible scientific research involving human stem cells . National Archives and Records Administration. https://obamawhitehouse.archives.gov/the-press-office/removing-barriers-responsible-scientific-research-involving-human-stem-cells

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[13] Source for further reading: Tangwa G. B. (2007). Moral status of embryonic stem cells: perspective of an African villager. Bioethics , 21(8), 449–457. https://doi.org/10.1111/j.1467-8519.2007.00582.x , see also Mnisi, F. M. (2020). An African analysis based on ethics of Ubuntu - are human embryonic stem cell patents morally justifiable? African Insight , 49 (4).

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[17] Department of Health Republic of South Africa. (2021). Health Research Priorities (revised) for South Africa 2021-2024 . National Health Research Strategy. https://www.health.gov.za/wp-content/uploads/2022/05/National-Health-Research-Priorities-2021-2024.pdf

[18] Oosthuizen, H. (2013). Legal and Ethical Issues in Stem Cell Research in South Africa. In: Beran, R. (eds) Legal and Forensic Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-32338-6_80 , see also: Gaobotse G (2018) Stem Cell Research in Africa: Legislation and Challenges. J Regen Med 7:1. doi: 10.4172/2325-9620.1000142

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[21] Kooli, C. Review of assisted reproduction techniques, laws, and regulations in Muslim countries.  Middle East Fertil Soc J   24 , 8 (2020). https://doi.org/10.1186/s43043-019-0011-0 ; Gaobotse, G. (2018) Stem Cell Research in Africa: Legislation and Challenges. J Regen Med 7:1. doi: 10.4172/2325-9620.1000142

[22] Pang M. C. (1999). Protective truthfulness: the Chinese way of safeguarding patients in informed treatment decisions. Journal of medical ethics , 25(3), 247–253. https://doi.org/10.1136/jme.25.3.247

[23] Wang, L., Wang, F., & Zhang, W. (2021). Bioethics in China’s biosecurity law: Forms, effects, and unsettled issues. Journal of law and the biosciences , 8(1).  https://doi.org/10.1093/jlb/lsab019 https://academic.oup.com/jlb/article/8/1/lsab019/6299199

[24] Wang, Y., Xue, Y., & Guo, H. D. (2022). Intervention effects of traditional Chinese medicine on stem cell therapy of myocardial infarction.  Frontiers in pharmacology ,  13 , 1013740. https://doi.org/10.3389/fphar.2022.1013740

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[30] Chen, H., Wei, T., Wang, H.  et al.  Association of China’s two-child policy with changes in number of births and birth defects rate, 2008–2017.  BMC Public Health   22 , 434 (2022). https://doi.org/10.1186/s12889-022-12839-0

[31] Azuma, K. Regulatory Landscape of Regenerative Medicine in Japan.  Curr Stem Cell Rep   1 , 118–128 (2015). https://doi.org/10.1007/s40778-015-0012-6

[32] Harris, R. (2005, May 19). Researchers Report Advance in Stem Cell Production . NPR. https://www.npr.org/2005/05/19/4658967/researchers-report-advance-in-stem-cell-production

[33] Park, S. (2012). South Korea steps up stem-cell work.  Nature . https://doi.org/10.1038/nature.2012.10565

[34] Resnik, D. B., Shamoo, A. E., & Krimsky, S. (2006). Fraudulent human embryonic stem cell research in South Korea: lessons learned.  Accountability in research ,  13 (1), 101–109. https://doi.org/10.1080/08989620600634193 .

[35] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: interviews with researchers from Saudi Arabia. BMC medical ethics, 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6

[36] Association for the Advancement of Blood and Biotherapies.  https://www.aabb.org/regulatory-and-advocacy/regulatory-affairs/regulatory-for-cellular-therapies/international-competent-authorities/saudi-arabia

[37] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: Interviews with researchers from Saudi Arabia.  BMC medical ethics ,  21 (1), 35. https://doi.org/10.1186/s12910-020-00482-6

[38] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: Interviews with researchers from Saudi Arabia. BMC medical ethics , 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6

Culturally, autonomy practices follow a relational autonomy approach based on a paternalistic deontological health care model. The adherence to strict international research policies and religious pillars within the regulatory environment is a great foundation for research ethics. However, there is a need to develop locally targeted ethics approaches for research (as called for in Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: interviews with researchers from Saudi Arabia. BMC medical ethics, 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6), this decision-making approach may help advise a research decision model. For more on the clinical cultural autonomy approaches, see: Alabdullah, Y. Y., Alzaid, E., Alsaad, S., Alamri, T., Alolayan, S. W., Bah, S., & Aljoudi, A. S. (2022). Autonomy and paternalism in Shared decision‐making in a Saudi Arabian tertiary hospital: A cross‐sectional study. Developing World Bioethics , 23 (3), 260–268. https://doi.org/10.1111/dewb.12355 ; Bukhari, A. A. (2017). Universal Principles of Bioethics and Patient Rights in Saudi Arabia (Doctoral dissertation, Duquesne University). https://dsc.duq.edu/etd/124; Ladha, S., Nakshawani, S. A., Alzaidy, A., & Tarab, B. (2023, October 26). Islam and Bioethics: What We All Need to Know . Columbia University School of Professional Studies. https://sps.columbia.edu/events/islam-and-bioethics-what-we-all-need-know

[39] Ababneh, M. A., Al-Azzam, S. I., Alzoubi, K., Rababa’h, A., & Al Demour, S. (2021). Understanding and attitudes of the Jordanian public about clinical research ethics.  Research Ethics ,  17 (2), 228-241.  https://doi.org/10.1177/1747016120966779

[40] Ababneh, M. A., Al-Azzam, S. I., Alzoubi, K., Rababa’h, A., & Al Demour, S. (2021). Understanding and attitudes of the Jordanian public about clinical research ethics.  Research Ethics ,  17 (2), 228-241.  https://doi.org/10.1177/1747016120966779

[41] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[42] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[43] The EU’s definition of autonomy relates to the capacity for creating ideas, moral insight, decisions, and actions without constraint, personal responsibility, and informed consent. However, the EU views autonomy as not completely able to protect individuals and depends on other principles, such as dignity, which “expresses the intrinsic worth and fundamental equality of all human beings.” Rendtorff, J.D., Kemp, P. (2019). Four Ethical Principles in European Bioethics and Biolaw: Autonomy, Dignity, Integrity and Vulnerability. In: Valdés, E., Lecaros, J. (eds) Biolaw and Policy in the Twenty-First Century. International Library of Ethics, Law, and the New Medicine, vol 78. Springer, Cham. https://doi.org/10.1007/978-3-030-05903-3_3

[44] Council of Europe. Convention for the protection of Human Rights and Dignity of the Human Being with regard to the Application of Biology and Medicine: Convention on Human Rights and Biomedicine (ETS No. 164) https://www.coe.int/en/web/conventions/full-list?module=treaty-detail&treatynum=164 (forbidding the creation of embryos for research purposes only, and suggests embryos in vitro have protections.); Also see Drabiak-Syed B. K. (2013). New President, New Human Embryonic Stem Cell Research Policy: Comparative International Perspectives and Embryonic Stem Cell Research Laws in France.  Biotechnology Law Report ,  32 (6), 349–356. https://doi.org/10.1089/blr.2013.9865

[45] Rendtorff, J.D., Kemp, P. (2019). Four Ethical Principles in European Bioethics and Biolaw: Autonomy, Dignity, Integrity and Vulnerability. In: Valdés, E., Lecaros, J. (eds) Biolaw and Policy in the Twenty-First Century. International Library of Ethics, Law, and the New Medicine, vol 78. Springer, Cham. https://doi.org/10.1007/978-3-030-05903-3_3

[46] Tomuschat, C., Currie, D. P., Kommers, D. P., & Kerr, R. (Trans.). (1949, May 23). Basic law for the Federal Republic of Germany. https://www.btg-bestellservice.de/pdf/80201000.pdf

[47] Regulation of Stem Cell Research in Germany . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-germany

[48] Regulation of Stem Cell Research in Finland . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-finland

[49] Regulation of Stem Cell Research in Spain . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-spain

[50] Some sources to consider regarding ethics models or regulatory oversights of other cultures not covered:

Kara MA. Applicability of the principle of respect for autonomy: the perspective of Turkey. J Med Ethics. 2007 Nov;33(11):627-30. doi: 10.1136/jme.2006.017400. PMID: 17971462; PMCID: PMC2598110.

Ugarte, O. N., & Acioly, M. A. (2014). The principle of autonomy in Brazil: one needs to discuss it ...  Revista do Colegio Brasileiro de Cirurgioes ,  41 (5), 374–377. https://doi.org/10.1590/0100-69912014005013

Bharadwaj, A., & Glasner, P. E. (2012). Local cells, global science: The rise of embryonic stem cell research in India . Routledge.

For further research on specific European countries regarding ethical and regulatory framework, we recommend this database: Regulation of Stem Cell Research in Europe . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-europe   

[51] Klitzman, R. (2006). Complications of culture in obtaining informed consent. The American Journal of Bioethics, 6(1), 20–21. https://doi.org/10.1080/15265160500394671 see also: Ekmekci, P. E., & Arda, B. (2017). Interculturalism and Informed Consent: Respecting Cultural Differences without Breaching Human Rights.  Cultura (Iasi, Romania) ,  14 (2), 159–172.; For why trust is important in research, see also: Gray, B., Hilder, J., Macdonald, L., Tester, R., Dowell, A., & Stubbe, M. (2017). Are research ethics guidelines culturally competent?  Research Ethics ,  13 (1), 23-41.  https://doi.org/10.1177/1747016116650235

[52] The Qur'an  (M. Khattab, Trans.). (1965). Al-Mu’minun, 23: 12-14. https://quran.com/23

[53] Lenfest, Y. (2017, December 8). Islam and the beginning of human life . Bill of Health. https://blog.petrieflom.law.harvard.edu/2017/12/08/islam-and-the-beginning-of-human-life/

[54] Aksoy, S. (2005). Making regulations and drawing up legislation in Islamic countries under conditions of uncertainty, with special reference to embryonic stem cell research. Journal of Medical Ethics , 31: 399-403.; see also: Mahmoud, Azza. "Islamic Bioethics: National Regulations and Guidelines of Human Stem Cell Research in the Muslim World." Master's thesis, Chapman University, 2022. https://doi.org/10.36837/ chapman.000386

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[57] Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

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[59] There is no explicit religious reference to when life begins or how to conduct research that interacts with the concept of life. However, these are relevant verses pertaining to how the fetus is viewed. (( King James Bible . (1999). Oxford University Press. (original work published 1769))

Jerimiah 1: 5 “Before I formed thee in the belly I knew thee; and before thou camest forth out of the womb I sanctified thee…”

In prophet Jerimiah’s insight, God set him apart as a person known before childbirth, a theme carried within the Psalm of David.

Psalm 139: 13-14 “…Thou hast covered me in my mother's womb. I will praise thee; for I am fearfully and wonderfully made…”

These verses demonstrate David’s respect for God as an entity that would know of all man’s thoughts and doings even before birth.

[60] It should be noted that abortion is not supported as well.

[61] The Vatican. (1987, February 22). Instruction on Respect for Human Life in Its Origin and on the Dignity of Procreation Replies to Certain Questions of the Day . Congregation For the Doctrine of the Faith. https://www.vatican.va/roman_curia/congregations/cfaith/documents/rc_con_cfaith_doc_19870222_respect-for-human-life_en.html

[62] The Vatican. (2000, August 25). Declaration On the Production and the Scientific and Therapeutic Use of Human Embryonic Stem Cells . Pontifical Academy for Life. https://www.vatican.va/roman_curia/pontifical_academies/acdlife/documents/rc_pa_acdlife_doc_20000824_cellule-staminali_en.html ; Ohara, N. (2003). Ethical Consideration of Experimentation Using Living Human Embryos: The Catholic Church’s Position on Human Embryonic Stem Cell Research and Human Cloning. Department of Obstetrics and Gynecology . Retrieved from https://article.imrpress.com/journal/CEOG/30/2-3/pii/2003018/77-81.pdf.

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Olivia Bowers

MS Bioethics Columbia University (Disclosure: affiliated with Voices in Bioethics)

Mifrah Hayath

SM Candidate Harvard Medical School, MS Biotechnology Johns Hopkins University

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