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Dissertation examples

Listed below are some of the best examples of research projects and dissertations from undergraduate and taught postgraduate students at the University of Leeds We have not been able to gather examples from all schools. The module requirements for research projects may have changed since these examples were written. Refer to your module guidelines to make sure that you address all of the current assessment criteria. Some of the examples below are only available to access on campus.

• Undergraduate examples
• Taught Masters examples

What’s Included: The Dissertation Template

If you’re preparing to write your dissertation, thesis or research project, our free dissertation template is the perfect starting point. In the template, we cover every section step by step, with clear, straightforward explanations and examples .

The template’s structure is based on the tried and trusted best-practice format for formal academic research projects such as dissertations and theses. The template structure reflects the overall research process, ensuring your dissertation or thesis will have a smooth, logical flow from chapter to chapter.

The dissertation template covers the following core sections:

• The title page/cover page
• Abstract (sometimes also called the executive summary)
• Table of contents
• List of figures /list of tables
• Chapter 1: Introduction  (also available: in-depth introduction template )
• Chapter 2: Literature review  (also available: in-depth LR template )
• Chapter 3: Methodology (also available: in-depth methodology template )
• Chapter 4: Research findings /results (also available: results template )
• Chapter 5: Discussion /analysis of findings (also available: discussion template )
• Chapter 6: Conclusion (also available: in-depth conclusion template )
• Reference list

Each section is explained in plain, straightforward language , followed by an overview of the key elements that you need to cover within each section. We’ve also included practical examples to help you understand exactly what’s required in each section.

The cleanly-formatted Google Doc can be downloaded as a fully editable MS Word Document (DOCX format), so you can use it as-is or convert it to LaTeX.

FAQs: Dissertation Template

What format is the template (doc, pdf, ppt, etc.).

The dissertation template is provided as a Google Doc. You can download it in MS Word format or make a copy to your Google Drive. You’re also welcome to convert it to whatever format works best for you, such as LaTeX or PDF.

What types of dissertations/theses can this template be used for?

The template follows the standard best-practice structure for formal academic research projects such as dissertations or theses, so it is suitable for the vast majority of degrees, particularly those within the sciences.

Some universities may have some additional requirements, but these are typically minor, with the core structure remaining the same. Therefore, it’s always a good idea to double-check your university’s requirements before you finalise your structure.

Will this work for a research paper?

A research paper follows a similar format, but there are a few differences. You can find our research paper template here .

Is this template for an undergrad, Masters or PhD-level thesis?

This template can be used for a dissertation, thesis or research project at any level of study. It may be slight overkill for an undergraduate-level study, but it certainly won’t be missing anything.

How long should my dissertation/thesis be?

This depends entirely on your university’s specific requirements, so it’s best to check with them. As a general ballpark, Masters-level projects are usually 15,000 – 20,000 words in length, while Doctoral-level projects are often in excess of 60,000 words.

What about the research proposal?

If you’re still working on your research proposal, we’ve got a template for that here .

We’ve also got loads of proposal-related guides and videos over on the Grad Coach blog .

How do I write a literature review?

We have a wealth of free resources on the Grad Coach Blog that unpack how to write a literature review from scratch. You can check out the literature review section of the blog here.

How do I create a research methodology?

We have a wealth of free resources on the Grad Coach Blog that unpack research methodology, both qualitative and quantitative. You can check out the methodology section of the blog here.

Can I share this dissertation template with my friends/colleagues?

Yes, you’re welcome to share this template. If you want to post about it on your blog or social media, all we ask is that you reference this page as your source.

Can Grad Coach help me with my dissertation/thesis?

Within the template, you’ll find plain-language explanations of each section, which should give you a fair amount of guidance. However, you’re also welcome to consider our dissertation and thesis coaching services .

Home > ETDs > Doctoral Dissertations

Doctoral Dissertations

Dissertations from 2024 2024.

AN EXPLORATION OF ADULT CHILDREN’S ATTACHMENT TO THEIR PARENTS ACROSS TWO CULTURAL GROUPS: INDIANS IN INDIA AND INDIANS WHO IMMIGRATED TO THE UNITED STATES , Vilasini Meenakshi Arun

Evaluating the Client Base and Housing Outcomes of a Community Based Organization Serving Unhoused Adults , Emi Caprio

RESILIENT AF: UNDERSTANDING THE LIVED EXPERIENCES OF WOMEN OF COLOR PSYCHOLOGISTS IN FORENSIC MENTAL HEALTH SETTINGS , Carisse A. Cronquist

Creating whole inclusive worlds: The impact of social media usage on Black gender expansive millennials’ experiences of social support and identity development processes , Meredith J. Holmes

The Transition from In Person Sessions to Telemental Health Sessions for College Counseling Center Counselors , Katherine L. Karimian

An Exploration of the Contributions of Parenting Styles and Peer Relationships on the Emotional Expression of Second-Generation Indian-Americans , Smitha M. Kashi

THE ASSOCIATION BETWEEN UNCERTAINTY, REPRODUCTIVE DISTRESS, AND AVOIDANCE IN ASSIGNED FEMALE AT BIRTH ADOLESCENT AND YOUNG ADULT (AYA-F) CANCER SURVIVORS , Devon Ann Pons

Dissertations from 2023 2023

STUDENTS AS CO-RESEARCHERS: USING PARTICIPATORY ACTION RESEARCH TO ADDRESS COLLEGE FOOD INSECURITY , Rachel Brand

Power Dynamics of Sexual Assault on College Campuses , Jillian L. Chase

WE ARE STILL PLAYING: A META-ANALYSIS OF GAME-BASED LEARNING IN MATHEMATICS EDUCATION , Thomas Conmy

MOVING BETWEEN ENTITLEMENT AND CO-CONSPIRACY: A STUDY OF HOW SUPPORT, SKILLS, AND COMMUNITY CAN ADVANCE ANTI-RACISM EFFORTS OF WHITE PARENTS , Karin Marianne Cotterman

WHITE WOMANHOOD: FINDING OPPOSITIONAL EPISTEMOLOGIES AND COMMUNITY AT THE INTERSECTION OF WHITENESS AND WOMANHOOD , Hannah Joy Fischer

Understanding Filipino Wellness: Investigating the Effects of Colonial Mentality and Enculturation , Juliene Grace P. Fresnedi

A Qualitative Study of Ableism on the Postsecondary Campus , George Stuart Fuller

Alleviating Mathematics Anxiety For Middle School Students Using A Combined Intervention Approach Versus Only Using The Cognitive Intervention Approach For Increasing Mathematical Achievement: A Comparative Study , Patricia Anna Garcia

Parent-Child Conversations about Body Safety and Consent , Natasha Gerber

Experiences of Black American Millennials: A Qualitative Study of Internalized and Externalized Coping in the Face of Racial Trauma , Natalia Angelique Giles

The Mental Health of First-Generation College Students of Color , Devin Hallquist

Identity Formation and Role Expansion for Nurse Practitioner Residency Preceptors: A Qualitative Thematic Analysis , Angel Chen Kuo

Understanding the Lived Experiences of Ethnic-Racial Minority Former Foster Youth Who Identify as Queer , Cristian A. Lemus

THE EFFECTIVENESS OF INTERVENTIONS TO INCREASE ANTIRETROVIRAL THERAPY (ART) ADHERENCE AMONG LATINX MEN WHO HAVE SEX WITH MEN (MSM) WITH HUMAN IMMUNODEFICIENCY VIRUS (HIV) IN THE UNITED STATES: A SYSTEMATIC REVIEW , Everardo Leon

Mental Health and Experiences of Pregnancy Among Black Women and Birthing People with Type 1 Diabetes (T1D) , Madeleine E. Marcus

EARLY DIAGNOSIS METHODS FOR AUTISM SPECTRUM DISORDER: A SYSTEMATIC REVIEW , Megan Denise McCarthy

The Association between Psychotic Symptoms and Romantic Relationship Quality among Young Adult Ethnic Minorites , Tashagaye T. McKenzie

META-ANALYSIS OF THE EFFECTIVENESS OF PROJECT-BASED LEARNING APPROACH ON ACADEMIC ACHIEVEMENT IN HIGHER EDUCATION WORLDWIDE , Ziyu Meng

A Case Study of a School-Supported Extracurricular Activity's Influence on STEM Identity and Interest for Females , Letta Meyer

African American Women Make Meaning of Historical Trauma , Deidre A. MILLER

THE GRINDR COMPLEX: THE BEHAVIORAL HEALTH IMPACT OF SEXUAL RACISM ON LATINX MEN WHO HAVE SEX WITH MEN , Luisalfredo Plascencia

Working with Other Immigrants Brings the Parts That I Lost Back To Me: The Experiences of Latin American Immigrant Therapists Working with Latin American Immigrant Populations , Elizabeth P. Rivera

DECOLONIZING MENTAL HEALTH THROUGH HE/A/R/TOGRAPHY: CORAZONAR, SENTIPENSAR Y SENTISABER , Patricia Rojas-Zambrano

The Effects of Acculturation, Marianismo, and Religiosity on Pregnancy Related Anxiety in Latina Women , Jennifer M. Zanoli

Dissertations from 2022 2022

A Collaborative Autoethnography: Your Passport to Immigrant Women of Color Leader's Stories of Identity Exploration and Leadership Barriers and Possibilities , Fraylanie Adan Aglipay

RECLAIMING OUR HUMANITY: REDEMPTION, REIMAGINING, AND RESTORYING OF THE FOUNDATIONS FOR SUCCESS OF FORMERLY INCARCERATED AFRICAN AMERICAN MALES , Robert Mossi Alexander III

Fifty Years of Underrepresented Student Advocacy at One Jesuit Secondary School , Sonya Cotero Arriola

Voces of Little Michoacan: A Collective Narrative of Resistance and Preservation of Home , Ana Angel Avendaño

CLINICIANS' PERSPECTIVES ON THE EFFECTIVENESS OF TRAUMA - FOCUSED COGNITIVE BEHAVIORAL THERAPY WITH AFRICAN AMERICAN CHILDREN: A QUALITATIVE STUDY , Jada Carter

The Use of Simulation with the School of Nursing and Health Professions (SONHP) Prelicensure Students to Support Affirming Practice with Transgender Communities , Genevieve Charbonneau

Understanding the perspectives, practices, and expectations of Korean American parents toward the heritage language education of their children , Yunhee Choi

The Association between Physical Pain, Depression, Anxiety, and Nervios among Latinx Agricultural Workers , Iveth Cuellar Celallos

Incorporating Andragogy and Cognitive Theory Of Multimedia Learning Into Self-Paced Training and Development Programs , Shanshan Gao

An Exploration of Learning-At-Home Experiences Among Families and Children of Color Labeled with Disabilities During COVID-19: A Narrative Inquiry , Nam Ju Han

"What’s Race Got To Do With It?”: A Virtual Participatory Action Research Study of Community College Students Exploring Intersectionality In Queer Studies , Breana Hansen

"MY BODY GOES NUMB A LOT OF THE TIME": EXAMINING HIGH SCHOOL STUDENT-ATHLETE EXPERIENCES USING YOUTH PARTICIPATORY ACTION RESEARCH AND EMBODIED CULTURALLY RELEVANT PEDAGOGY , Gabriela Elizabeth Holmes

TOWARDS CHARISM IDENTITY: A CATHOLIC IDENTITY CASE STUDY THROUGH THE LENS OF LAUDATO SI’ , Kristofer Ross Koller

Teaching Solidarity: Popular Education in Grassroots U.S. Social Movements , Tenaya Summers Lafore

The Effects of Curriculum-Integrated Explicit Learning Strategy Instruction on Reading Comprehension for English as a Second Language (ESL) Learners at the Community College , Sylvia Chaiyeon Lee

Genocide in East Turkestan: Exploring the Perspectives of Uyghurs in the Diaspora and their Resistance to Chinese State Violence , Lina Semyonovna Lenberg

Mediating Language Fluency Development: An Action Research Study In A High-School AP Chinese Second-or-Foreign-Language Task-Based Language Teaching Classroom , Jing Liang

EFFORTS TO CREATE A TRAUMA-INFORMED CLASSROOM IN HIGHER EDUCATION: INSIGHTS FROM MEMBERS OF A COMMUNITY COLLEGE TRAUMA-INFORMED TEACHING GROUP , Danyelle Marshall

Women in Senior Leadership Roles Career Mobility, Challenges, Success Stories and Need for Future Research , Giselle Flores Martin

Impact of COVID-19 on New Teacher Retention and Perceived Supports in a Northern California Public School District , Rebecka Maxkenzie

African American Female Identified Therapists' Experiences Working Culturally Similar and Dissimilar Populations , Kimiko J. May

EXPLORING LATINX PARENTS’ EXPERIENCES WITH SPECIAL EDUCATION: DEVELOPING A COMMUNITY-BASED WORKSHOP TO EMPOWER LATINX PARENTS OF CHILDREN IN SPECIAL EDUCATION , Gabriela Alejandra Perez

BLACK MOTHERING IN THE BAY AREA WHILE UNSEEN AND UNHEARD: NAVIGATING BLACK MOTHERING IN THE MIDST OF A PANDEMIC & SOCIAL UNREST , Kassie Michelle Phillips

Feminist Catholic Organizational Identity: A Phenomenological Study of Charism in the Lay Educator of a Notre Dame de Namur Learning Community , Kathleen Barrera Quiazon

Effects of Teaching Argument to First-Year Community-College Students Using a Structural and Dialectical Approach , Sharon Radcliff

¿TÚ QUÉ SABES?: LATINA DOCTORAL WOMEN DISRUPTING AND RESISTING DOMINANT KNOWLEDGE , Sendy Ramos Madsen

HEARING IMPAIRED AND LEADERSHIP: STRUGGLES OF INDIVIDUALS WITH HEARING LOSS IN THE WORKPLACE , John Cleese Relihan

Cuentos Criollos: Colombian Internally Displaced Families as Knowledge Producers , Liliana Salazar de Deck

An Exploration of Higher Educational Experiences For Mixed Blood American Indian Males in the Santa Clara Valley , Edward Salcedo

APPLICATION OF THE EPISTEMOLOGIES OF THE SOUTH TO ADDRESS THE ECOLOGICAL CRISIS: A NARRATIVE CASE STUDY OF BURKINA FASO AND THE LEADER YACOUBA SAWADOGO , Barwendé Médard Sané

The Relationship Between Metacognitive Strategies and Listening Comprehension Proficiency in Intensive-Korean-Foreign-Language Setting , Gumok Seo

The Collegiate Black Space: Black College Students’ Use of New Counter-Spaces for Support, Knowledge Production, and Organizing for Activism , Heather Streets

The Impact of #MeToo on Reasons for Sexual Assault Disclosure , Cheryl H. Tien

Developing Queer Faith: Exploring Experiences of Cognitive Dissonance and Identity Integration For LGBQ Catholics Individuals , Kendal M. Vaarwerk

Using Peer Review to Improve English as a Second Language College Students' Writing Scores , Mengjie Wei

Dissertations from 2021 2021

The Effect of Teaching and Learning Vocabulary in Lexical Chunks on the Listening Comprehension of Adult Learners of Arabic , Bassam Al-Maqtari

Exploring Student Engagement for Diverse Student Populations: A Case Study Examining Institutional Logics of Student Affairs Middle Management Leaders , Frangelo Rominque Ayran

Employment Discrimination: An Efficacy Study of African American Inequities in the California Utility Sector , Victor Baker

Mental Health Outcomes of Various Types of Fear Among University Students who have an Undocumented Legal Status During the Donald Trump Presidency , Liliana Campos

Experiences of UC Santa Barbara female alumni exposed to a gender-based mass shooting , Erin G. Carpenter

Majority to Minority Shift: Experiences for American Born Chinese College Students from Predominant Chinese American Communities to Predominantly White Institutions , Joseph C. Chung

The Role of Community Building in Second Language Acquisition in the Mainstream Classroom , Alejandro Clemente Fernandez

The Effectiveness of Using Multimedia for Teaching Phrasal Verbs in Community-College ESL Classes , Guohua Fu

Replanting a Wild Seed: Black Women School Leaders Subverting Ideological Lynching , Whitneé Louise Garrett-Walker

The Significance of Jesuit Educational Institution in the Reconstruction of Postcolonial and Post-Conflict East Timor , Plinio do Rosario Gusmao dosReis Martins

Effects of Static and Dynamic Visuals on the Learning of Science Concepts in the Secondary-School Classroom , Theodore Johnson

Impact of Moral Injury for Ethnic/Racial Minority Male Veterans , Kristopher Kern

Dysconscious Racism and Racial Microaggressions in the Public School System , Ryan Lee

Stigma and Social-Emotional Health in Youth with Learning Differences , Kelsey Maki

Provider Perspectives: Working with the Male Lifer Reentry Population , Laura R. Marker Dr.

Women Who Lead: A Feminist Phenomenology of Crisis Leadership in Higher Education , Ingrid Helene McVanner

The Use of Mindfulness Meditation to Increase the Efficacy of Mirror Visual Feedback for Reducing Phantom Limb Pain in Amputees , Nicolas Sebastian Mills

A Minority Within a Minority: Exploring Identity Development in Relation to Mental Health Outcomes Within the Black Deaf Community , Nekolas Milton

Community Based Participatory Research Informed Manualization and Piloting of E-Training of a Modified Dialectical Behavior Therapy Intervention , Annika M. Miyamoto

Early Childhood Special Education Teachers’ Attitudes Toward Inclusion: A Qualitative Study on a School’s Transition From Segregated Classrooms to More Inclusion Classrooms , Shally Moua

The Ignatian Pedagogical Paradigm as a Critical Theoretical Framework to Enhance Teachers' Professional Identity in Diverse Context , Lourdu Sunder Reddy Mummadi

Patient Reported Outcomes in Sickle Cell Disease Examined Within a Conceptual Model , Swapandeep Mushiana; Marsha Treadwell PhD; Sherif M. Badawy MD, MS; Liliana Preiss PhD; Allison King MD MPH PhD; Barbara Kroner PhD; Yumie Chen BS; Jeffrey Glassberg; Victor Gordeuk MD; Nirmish Shah MD; Angie Snyder Phd MPH; and Theodore Wun MD

Incorporating Critical Perspectives in Nonprofit Management Education Programs: How Critical Scholars of Color Navigate Pressures in Higher Education , Khanh H. Nguyen

A Critical Feminist Case Study of the Northern California Cherry Blossom Queen Program , Alison Kepola Nishiyama-Young

Understanding the African American Male Student Experience of Being Diagnosed with Emotional Disturbance Through the Use of Counter-Storytelling , Sara Ordaz

Sex or Sexual Assault? Critical Media Literacy as a Tool for Consent Education , Riana S. Pella

Higher Education Discourses of India’s National Education Policy 2020: Analysis and Teacher Counterspaces in Jesuit Institutions , Vincent Pereppadan Poulose

Effect of Transcendental Meditation on the Social Emotional Well-being of Bilingual Teacher Leaders , Margaret Peterson

Engaging Feminism, Transforming Institutions: How Community Engagement Professionals Employ Critical Feminist Praxis to Re-Imagine and Re-Shape the Public Purpose of Higher Education , Patricia Star Plaxton-Moore

Effect of Prenatal Yoga on Depression, Anxiety, and Maternal-fetal Attachment Among Pregnant Black, Indigenous and People of Color , Alicia Ranucci

The Effectiveness Of A Transaffirmative Cognitive Behavioral Therapy Group-Based Intervention To Help Transgender Individuals Suffering From Depression , Joy Riach

Investigating the Self-Efficacy Awareness of Black Female Technology Leaders , Marie Roberts De La Parra

Parental Involvement in Support of African American Families , September Rose

Pilipinx Radical Imagination: Healing and Visioning in our Process of Becoming , Anthony Abulencia Santa Ana

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15+ Dissertation Examples as a Sample (pdf and docs)

In this blog post, we will be sharing with you some of the dissertations papers written by students for their masters and Ph.D. degree.

As writing a dissertation can be a tough job, and it can be much tougher if you don’t know where to start. So, we have compiled a list of some best dissertation written by previous graduates.

You can take inspiration from these samples and learn how to structure and format your dissertation paper.

Dissertation Example For Applied Physics

Title: Functionalization of Single-walled Carbon Nanotubes with Bis-astraphloxin Category: Applied Physics Writer: Ebrima Saho Date: 2019 University: ASTON UNIVERSITY Degree: Bachelors Link: https://arxiv.org/ftp/arxiv/papers/1907/1907.10752.pdf

Dissertation Example 2

Title: Calculation and selection of silicon to glass anodic bonding modes based on the criterion of minimum residual stress Category: Engineering Sciences Writer: Leonid S. Sinev Date: 2016 University: Bauman Moscow State Technical University Degree: Bachelors Link: https://arxiv.org/pdf/1804.08644.pdf

Dissertation Example 3

Title: Code Obfuscation for the C/C++ Language Category: Programming Languages Writer: Dominik Picheta Date: 2018 University: The Queen’s University of Belfast Degree: Bachelors Link: https://arxiv.org/ftp/arxiv/papers/2003/2003.03449.pdf

Dissertation Example 4 for Astronomy

Title: Astrophysical Nuclear Reactions: from Hydrogen Burning to Supernovae Explosions Category: Astronomy Writer: Computing, Engineering & Physical Science Date: 2018 University: University of Central Lancashire Degree: Bachelors Link: https://arxiv.org/ftp/arxiv/papers/1806/1806.11179.pdf

Dissertation Example 5

Title: Data-Driven Method for Enhanced Corrosion Assessment of Reinforced Concrete Structures Category: Future Technologies Writer: Woubishet Zewdu Taffese Date: 2020 University: University of Turku Degree: Bachelors Link: https://arxiv.org/ftp/arxiv/papers/2007/2007.01164.pdf

Dissertation Example 6

Title: Collective patterns of pedestrians interacting with attractions Category: Built Environment Writer: Jaeyoung Kwak Date: 2017 University: Aalto University Degree: Doctorate Link: https://arxiv.org/pdf/1711.07833.pdf

Dissertation Example 7 For Computer Science

Title: Vector representations of text data in deep learning Category: Computer Science, Electronics and Telecommunications Writer: Karol Grzegorczyk Date: 2018 University: AGH University Degree: Doctorate Link: https://arxiv.org/pdf/1901.01695.pdf

Dissertation Example 8

Title: A Machine Learning Approach for Smartphone-based Sensing of Roads and Driving Style Category: Signal Processing Writer: MANUEL RICARDO CARLOS LOYA Date: 2019 University: Autonomous University of Chihuahua Degree: Doctorate Link: https://arxiv.org/pdf/1908.10187.pdf

Dissertation Example 9

Title: Accelerating the Understanding of Life’s Code Through Better Algorithms and Hardware Design Category: Computational Engineering, Finance, and Science Writer: Mohammed H K Alser Date: 2019 University: Bilkent University Degree: Doctorate Link: https://arxiv.org/pdf/1910.03936.pdf

Dissertation Example 10 in AI

Title: A Neural-Symbolic Framework for Mental Simulation Category: Artificial Intelligence Writer: Michael Kissner Date: 2020 University: Bundeswehr University Munich Degree: Doctorate Link: https://arxiv.org/pdf/2008.02356.pdf

Dissertation Example 11

Title: On the theory and applications of mechanism design and coalitional games in electricity markets Category: Computer Science and Game Theory Writer: Orcun Karaca Date: 2020 University: ETH Zürich Degree: Doctorate Link: https://arxiv.org/pdf/2012.05047.pdf

Dissertation Example 12

Title: Applications of a Graph Theoretic Based Clustering Framework in Computer Vision and Pattern Recognition Category: Computer Vision and Pattern Recognition Writer: Yonatan Tariku Tesfaye Date: 2018 University: Iuav University of Venice Degree: Doctorate Link: https://arxiv.org/pdf/1802.02181.pdf

Dissertation Example 13

Title: Investigations of fundamental symmetries with the electron-positron systems Category: Physics, Astronomy and Applied Computer Science Writer: Aleksander Gajos Date: 2018 University: Jagiellonian University Degree: Doctorate Link: https://arxiv.org/pdf/1805.06009.pdf

Let us know if you want samples for specific topic or subject in the comments and we will add some more examples focusing on the topic.

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Argumentative Thesis Statement

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In the realm of persuasive writing, the argumentative thesis statement stands as a pivotal element, guiding the entire context of an essay or research paper. It serves as the beacon that directs your work, letting readers know not only what to expect but also the position you’re advocating. This article dives into the depths of argumentative thesis statement examples, unraveling their significance, and offering a step-by-step guide on how to create one effectively.

3+ Argumentative Thesis Statement Examples

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What is an Argumentative Thesis Statement?

Before we delve into the intricacies of crafting a compelling argumentative thesis statement, let’s clarify what this vital element entails. An argumentative thesis statement serves as the core assertion of your essay, presenting your stance on a particular theme or topic. It goes beyond a mere description of the subject; it takes a firm position that you will defend with logical reasoning, evidence, and persuasion.

How to Craft an Argumentative Thesis Statement

Creating an argumentative thesis statement requires a methodical approach. By following these steps, you’ll be better equipped to develop a thesis that not only captures the essence of your argument but also engages readers from the outset.

Step 1: Identify Your Topic and Stance

The first step involves identifying the simple subject you’re addressing and your position on it before starting with the introduction . Your stance could be an assertion, a judgment, or an evaluation, shaping the tone and direction of your entire argument.

Step 2: Analyze Your Audience

Understanding your audience is crucial. Consider their perspectives, beliefs, and potential objections. Tailoring your argumentative thesis statement to resonate with your readers enhances the persuasiveness of your message.

Step 3: Develop a Concise Thesis

A strong thesis is concise and focused. It should encapsulate your main argument while giving a glimpse of the supporting points you’ll discuss. Avoid vague language and ensure your thesis statement is clear and direct.

Step 4: Incorporate Cause and Effect

A compelling argumentative thesis statement often involves demonstrating the cause-and-effect relationship between your stance and the topic. Highlight how certain actions, beliefs, or decisions lead to specific outcomes.

Can my argumentative thesis statement evolve as I research and write?

Absolutely. Your thesis can and should evolve based on your research findings and the development of your argument. Flexibility allows you to refine and strengthen your position.

How can I avoid falling into clichés when crafting my thesis statement?

To avoid clichés , strive for originality. Instead of using well-worn phrases, express your position in a unique way that showcases your perspective and analytical depth.

Should I include counterarguments in my thesis statement?

While it’s not necessary to include counterarguments in your thesis statement, acknowledging opposing viewpoints can add credibility to your argument. However, save the detailed counterarguments for the body of your essay.

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Cultural Relativity and Acceptance of Embryonic Stem Cell Research

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There is a debate about the ethical implications of using human embryos in stem cell research, which can be influenced by cultural, moral, and social values. This paper argues for an adaptable framework to accommodate diverse cultural and religious perspectives. By using an adaptive ethics model, research protections can reflect various populations and foster growth in stem cell research possibilities.

INTRODUCTION

Stem cell research combines biology, medicine, and technology, promising to alter health care and the understanding of human development. Yet, ethical contention exists because of individuals’ perceptions of using human embryos based on their various cultural, moral, and social values. While these disagreements concerning policy, use, and general acceptance have prompted the development of an international ethics policy, such a uniform approach can overlook the nuanced ethical landscapes between cultures. With diverse viewpoints in public health, a single global policy, especially one reflecting Western ethics or the ethics prevalent in high-income countries, is impractical. This paper argues for a culturally sensitive, adaptable framework for the use of embryonic stem cells. Stem cell policy should accommodate varying ethical viewpoints and promote an effective global dialogue. With an extension of an ethics model that can adapt to various cultures, we recommend localized guidelines that reflect the moral views of the people those guidelines serve.

Stem cells, characterized by their unique ability to differentiate into various cell types, enable the repair or replacement of damaged tissues. Two primary types of stem cells are somatic stem cells (adult stem cells) and embryonic stem cells. Adult stem cells exist in developed tissues and maintain the body’s repair processes. [1] Embryonic stem cells (ESC) are remarkably pluripotent or versatile, making them valuable in research. [2] However, the use of ESCs has sparked ethics debates. Considering the potential of embryonic stem cells, research guidelines are essential. The International Society for Stem Cell Research (ISSCR) provides international stem cell research guidelines. They call for “public conversations touching on the scientific significance as well as the societal and ethical issues raised by ESC research.” [3] The ISSCR also publishes updates about culturing human embryos 14 days post fertilization, suggesting local policies and regulations should continue to evolve as ESC research develops. [4]  Like the ISSCR, which calls for local law and policy to adapt to developing stem cell research given cultural acceptance, this paper highlights the importance of local social factors such as religion and culture.

I.     Global Cultural Perspective of Embryonic Stem Cells

Views on ESCs vary throughout the world. Some countries readily embrace stem cell research and therapies, while others have stricter regulations due to ethical concerns surrounding embryonic stem cells and when an embryo becomes entitled to moral consideration. The philosophical issue of when the “someone” begins to be a human after fertilization, in the morally relevant sense, [5] impacts when an embryo becomes not just worthy of protection but morally entitled to it. The process of creating embryonic stem cell lines involves the destruction of the embryos for research. [6] Consequently, global engagement in ESC research depends on social-cultural acceptability.

a.     US and Rights-Based Cultures

In the United States, attitudes toward stem cell therapies are diverse. The ethics and social approaches, which value individualism, [7] trigger debates regarding the destruction of human embryos, creating a complex regulatory environment. For example, the 1996 Dickey-Wicker Amendment prohibited federal funding for the creation of embryos for research and the destruction of embryos for “more than allowed for research on fetuses in utero.” [8] Following suit, in 2001, the Bush Administration heavily restricted stem cell lines for research. However, the Stem Cell Research Enhancement Act of 2005 was proposed to help develop ESC research but was ultimately vetoed. [9] Under the Obama administration, in 2009, an executive order lifted restrictions allowing for more development in this field. [10] The flux of research capacity and funding parallels the different cultural perceptions of human dignity of the embryo and how it is socially presented within the country’s research culture. [11]

b.     Ubuntu and Collective Cultures

African bioethics differs from Western individualism because of the different traditions and values. African traditions, as described by individuals from South Africa and supported by some studies in other African countries, including Ghana and Kenya, follow the African moral philosophies of Ubuntu or Botho and Ukama , which “advocates for a form of wholeness that comes through one’s relationship and connectedness with other people in the society,” [12] making autonomy a socially collective concept. In this context, for the community to act autonomously, individuals would come together to decide what is best for the collective. Thus, stem cell research would require examining the value of the research to society as a whole and the use of the embryos as a collective societal resource. If society views the source as part of the collective whole, and opposes using stem cells, compromising the cultural values to pursue research may cause social detachment and stunt research growth. [13] Based on local culture and moral philosophy, the permissibility of stem cell research depends on how embryo, stem cell, and cell line therapies relate to the community as a whole. Ubuntu is the expression of humanness, with the person’s identity drawn from the “’I am because we are’” value. [14] The decision in a collectivistic culture becomes one born of cultural context, and individual decisions give deference to others in the society.

Consent differs in cultures where thought and moral philosophy are based on a collective paradigm. So, applying Western bioethical concepts is unrealistic. For one, Africa is a diverse continent with many countries with different belief systems, access to health care, and reliance on traditional or Western medicines. Where traditional medicine is the primary treatment, the “’restrictive focus on biomedically-related bioethics’” [is] problematic in African contexts because it neglects bioethical issues raised by traditional systems.” [15] No single approach applies in all areas or contexts. Rather than evaluating the permissibility of ESC research according to Western concepts such as the four principles approach, different ethics approaches should prevail.

Another consideration is the socio-economic standing of countries. In parts of South Africa, researchers have not focused heavily on contributing to the stem cell discourse, either because it is not considered health care or a health science priority or because resources are unavailable. [16] Each country’s priorities differ given different social, political, and economic factors. In South Africa, for instance, areas such as maternal mortality, non-communicable diseases, telemedicine, and the strength of health systems need improvement and require more focus [17] Stem cell research could benefit the population, but it also could divert resources from basic medical care. Researchers in South Africa adhere to the National Health Act and Medicines Control Act in South Africa and international guidelines; however, the Act is not strictly enforced, and there is no clear legislation for research conduct or ethical guidelines. [18]

Some parts of Africa condemn stem cell research. For example, 98.2 percent of the Tunisian population is Muslim. [19] Tunisia does not permit stem cell research because of moral conflict with a Fatwa. Religion heavily saturates the regulation and direction of research. [20] Stem cell use became permissible for reproductive purposes only recently, with tight restrictions preventing cells from being used in any research other than procedures concerning ART/IVF.  Their use is conditioned on consent, and available only to married couples. [21] The community's receptiveness to stem cell research depends on including communitarian African ethics.

c.     Asia

Some Asian countries also have a collective model of ethics and decision making. [22] In China, the ethics model promotes a sincere respect for life or human dignity, [23] based on protective medicine. This model, influenced by Traditional Chinese Medicine (TCM), [24] recognizes Qi as the vital energy delivered via the meridians of the body; it connects illness to body systems, the body’s entire constitution, and the universe for a holistic bond of nature, health, and quality of life. [25] Following a protective ethics model, and traditional customs of wholeness, investment in stem cell research is heavily desired for its applications in regenerative therapies, disease modeling, and protective medicines. In a survey of medical students and healthcare practitioners, 30.8 percent considered stem cell research morally unacceptable while 63.5 percent accepted medical research using human embryonic stem cells. Of these individuals, 89.9 percent supported increased funding for stem cell research. [26] The scientific community might not reflect the overall population. From 1997 to 2019, China spent a total of $576 million (USD) on stem cell research at 8,050 stem cell programs, increased published presence from 0.6 percent to 14.01 percent of total global stem cell publications as of 2014, and made significant strides in cell-based therapies for various medical conditions. [27] However, while China has made substantial investments in stem cell research and achieved notable progress in clinical applications, concerns linger regarding ethical oversight and transparency. [28] For example, the China Biosecurity Law, promoted by the National Health Commission and China Hospital Association, attempted to mitigate risks by introducing an institutional review board (IRB) in the regulatory bodies. 5800 IRBs registered with the Chinese Clinical Trial Registry since 2021. [29] However, issues still need to be addressed in implementing effective IRB review and approval procedures.

The substantial government funding and focus on scientific advancement have sometimes overshadowed considerations of regional cultures, ethnic minorities, and individual perspectives, particularly evident during the one-child policy era. As government policy adapts to promote public stability, such as the change from the one-child to the two-child policy, [30] research ethics should also adapt to ensure respect for the values of its represented peoples.

Japan is also relatively supportive of stem cell research and therapies. Japan has a more transparent regulatory framework, allowing for faster approval of regenerative medicine products, which has led to several advanced clinical trials and therapies. [31] South Korea is also actively engaged in stem cell research and has a history of breakthroughs in cloning and embryonic stem cells. [32] However, the field is controversial, and there are issues of scientific integrity. For example, the Korean FDA fast-tracked products for approval, [33] and in another instance, the oocyte source was unclear and possibly violated ethical standards. [34] Trust is important in research, as it builds collaborative foundations between colleagues, trial participant comfort, open-mindedness for complicated and sensitive discussions, and supports regulatory procedures for stakeholders. There is a need to respect the culture’s interest, engagement, and for research and clinical trials to be transparent and have ethical oversight to promote global research discourse and trust.

d.     Middle East

Countries in the Middle East have varying degrees of acceptance of or restrictions to policies related to using embryonic stem cells due to cultural and religious influences. Saudi Arabia has made significant contributions to stem cell research, and conducts research based on international guidelines for ethical conduct and under strict adherence to guidelines in accordance with Islamic principles. Specifically, the Saudi government and people require ESC research to adhere to Sharia law. In addition to umbilical and placental stem cells, [35] Saudi Arabia permits the use of embryonic stem cells as long as they come from miscarriages, therapeutic abortions permissible by Sharia law, or are left over from in vitro fertilization and donated to research. [36] Laws and ethical guidelines for stem cell research allow the development of research institutions such as the King Abdullah International Medical Research Center, which has a cord blood bank and a stem cell registry with nearly 10,000 donors. [37] Such volume and acceptance are due to the ethical ‘permissibility’ of the donor sources, which do not conflict with religious pillars. However, some researchers err on the side of caution, choosing not to use embryos or fetal tissue as they feel it is unethical to do so. [38]

Jordan has a positive research ethics culture. [39] However, there is a significant issue of lack of trust in researchers, with 45.23 percent (38.66 percent agreeing and 6.57 percent strongly agreeing) of Jordanians holding a low level of trust in researchers, compared to 81.34 percent of Jordanians agreeing that they feel safe to participate in a research trial. [40] Safety testifies to the feeling of confidence that adequate measures are in place to protect participants from harm, whereas trust in researchers could represent the confidence in researchers to act in the participants’ best interests, adhere to ethical guidelines, provide accurate information, and respect participants’ rights and dignity. One method to improve trust would be to address communication issues relevant to ESC. Legislation surrounding stem cell research has adopted specific language, especially concerning clarification “between ‘stem cells’ and ‘embryonic stem cells’” in translation. [41] Furthermore, legislation “mandates the creation of a national committee… laying out specific regulations for stem-cell banking in accordance with international standards.” [42] This broad regulation opens the door for future global engagement and maintains transparency. However, these regulations may also constrain the influence of research direction, pace, and accessibility of research outcomes.

e.     Europe

In the European Union (EU), ethics is also principle-based, but the principles of autonomy, dignity, integrity, and vulnerability are interconnected. [43] As such, the opportunity for cohesion and concessions between individuals’ thoughts and ideals allows for a more adaptable ethics model due to the flexible principles that relate to the human experience The EU has put forth a framework in its Convention for the Protection of Human Rights and Dignity of the Human Being allowing member states to take different approaches. Each European state applies these principles to its specific conventions, leading to or reflecting different acceptance levels of stem cell research. [44]

For example, in Germany, Lebenzusammenhang , or the coherence of life, references integrity in the unity of human culture. Namely, the personal sphere “should not be subject to external intervention.” [45]  Stem cell interventions could affect this concept of bodily completeness, leading to heavy restrictions. Under the Grundgesetz, human dignity and the right to life with physical integrity are paramount. [46] The Embryo Protection Act of 1991 made producing cell lines illegal. Cell lines can be imported if approved by the Central Ethics Commission for Stem Cell Research only if they were derived before May 2007. [47] Stem cell research respects the integrity of life for the embryo with heavy specifications and intense oversight. This is vastly different in Finland, where the regulatory bodies find research more permissible in IVF excess, but only up to 14 days after fertilization. [48] Spain’s approach differs still, with a comprehensive regulatory framework. [49] Thus, research regulation can be culture-specific due to variations in applied principles. Diverse cultures call for various approaches to ethical permissibility. [50] Only an adaptive-deliberative model can address the cultural constructions of self and achieve positive, culturally sensitive stem cell research practices. [51]

II.     Religious Perspectives on ESC

Embryonic stem cell sources are the main consideration within religious contexts. While individuals may not regard their own religious texts as authoritative or factual, religion can shape their foundations or perspectives.

The Qur'an states:

“And indeed We created man from a quintessence of clay. Then We placed within him a small quantity of nutfa (sperm to fertilize) in a safe place. Then We have fashioned the nutfa into an ‘alaqa (clinging clot or cell cluster), then We developed the ‘alaqa into mudgha (a lump of flesh), and We made mudgha into bones, and clothed the bones with flesh, then We brought it into being as a new creation. So Blessed is Allah, the Best of Creators.” [52]

Many scholars of Islam estimate the time of soul installment, marked by the angel breathing in the soul to bring the individual into creation, as 120 days from conception. [53] Personhood begins at this point, and the value of life would prohibit research or experimentation that could harm the individual. If the fetus is more than 120 days old, the time ensoulment is interpreted to occur according to Islamic law, abortion is no longer permissible. [54] There are a few opposing opinions about early embryos in Islamic traditions. According to some Islamic theologians, there is no ensoulment of the early embryo, which is the source of stem cells for ESC research. [55]

In Buddhism, the stance on stem cell research is not settled. The main tenets, the prohibition against harming or destroying others (ahimsa) and the pursuit of knowledge (prajña) and compassion (karuna), leave Buddhist scholars and communities divided. [56] Some scholars argue stem cell research is in accordance with the Buddhist tenet of seeking knowledge and ending human suffering. Others feel it violates the principle of not harming others. Finding the balance between these two points relies on the karmic burden of Buddhist morality. In trying to prevent ahimsa towards the embryo, Buddhist scholars suggest that to comply with Buddhist tenets, research cannot be done as the embryo has personhood at the moment of conception and would reincarnate immediately, harming the individual's ability to build their karmic burden. [57] On the other hand, the Bodhisattvas, those considered to be on the path to enlightenment or Nirvana, have given organs and flesh to others to help alleviate grieving and to benefit all. [58] Acceptance varies on applied beliefs and interpretations.

Catholicism does not support embryonic stem cell research, as it entails creation or destruction of human embryos. This destruction conflicts with the belief in the sanctity of life. For example, in the Old Testament, Genesis describes humanity as being created in God’s image and multiplying on the Earth, referencing the sacred rights to human conception and the purpose of development and life. In the Ten Commandments, the tenet that one should not kill has numerous interpretations where killing could mean murder or shedding of the sanctity of life, demonstrating the high value of human personhood. In other books, the theological conception of when life begins is interpreted as in utero, [59] highlighting the inviolability of life and its formation in vivo to make a religious point for accepting such research as relatively limited, if at all. [60] The Vatican has released ethical directives to help apply a theological basis to modern-day conflicts. The Magisterium of the Church states that “unless there is a moral certainty of not causing harm,” experimentation on fetuses, fertilized cells, stem cells, or embryos constitutes a crime. [61] Such procedures would not respect the human person who exists at these stages, according to Catholicism. Damages to the embryo are considered gravely immoral and illicit. [62] Although the Catholic Church officially opposes abortion, surveys demonstrate that many Catholic people hold pro-choice views, whether due to the context of conception, stage of pregnancy, threat to the mother’s life, or for other reasons, demonstrating that practicing members can also accept some but not all tenets. [63]

Some major Jewish denominations, such as the Reform, Conservative, and Reconstructionist movements, are open to supporting ESC use or research as long as it is for saving a life. [64] Within Judaism, the Talmud, or study, gives personhood to the child at birth and emphasizes that life does not begin at conception: [65]

“If she is found pregnant, until the fortieth day it is mere fluid,” [66]

Whereas most religions prioritize the status of human embryos, the Halakah (Jewish religious law) states that to save one life, most other religious laws can be ignored because it is in pursuit of preservation. [67] Stem cell research is accepted due to application of these religious laws.

We recognize that all religions contain subsets and sects. The variety of environmental and cultural differences within religious groups requires further analysis to respect the flexibility of religious thoughts and practices. We make no presumptions that all cultures require notions of autonomy or morality as under the common morality theory , which asserts a set of universal moral norms that all individuals share provides moral reasoning and guides ethical decisions. [68] We only wish to show that the interaction with morality varies between cultures and countries.

III.     A Flexible Ethical Approach

The plurality of different moral approaches described above demonstrates that there can be no universally acceptable uniform law for ESC on a global scale. Instead of developing one standard, flexible ethical applications must be continued. We recommend local guidelines that incorporate important cultural and ethical priorities.

While the Declaration of Helsinki is more relevant to people in clinical trials receiving ESC products, in keeping with the tradition of protections for research subjects, consent of the donor is an ethical requirement for ESC donation in many jurisdictions including the US, Canada, and Europe. [69] The Declaration of Helsinki provides a reference point for regulatory standards and could potentially be used as a universal baseline for obtaining consent prior to gamete or embryo donation.

For instance, in Columbia University’s egg donor program for stem cell research, donors followed standard screening protocols and “underwent counseling sessions that included information as to the purpose of oocyte donation for research, what the oocytes would be used for, the risks and benefits of donation, and process of oocyte stimulation” to ensure transparency for consent. [70] The program helped advance stem cell research and provided clear and safe research methods with paid participants. Though paid participation or covering costs of incidental expenses may not be socially acceptable in every culture or context, [71] and creating embryos for ESC research is illegal in many jurisdictions, Columbia’s program was effective because of the clear and honest communications with donors, IRBs, and related stakeholders.  This example demonstrates that cultural acceptance of scientific research and of the idea that an egg or embryo does not have personhood is likely behind societal acceptance of donating eggs for ESC research. As noted, many countries do not permit the creation of embryos for research.

Proper communication and education regarding the process and purpose of stem cell research may bolster comprehension and garner more acceptance. “Given the sensitive subject material, a complete consent process can support voluntary participation through trust, understanding, and ethical norms from the cultures and morals participants value. This can be hard for researchers entering countries of different socioeconomic stability, with different languages and different societal values. [72]

An adequate moral foundation in medical ethics is derived from the cultural and religious basis that informs knowledge and actions. [73] Understanding local cultural and religious values and their impact on research could help researchers develop humility and promote inclusion.

IV.     Concerns

Some may argue that if researchers all adhere to one ethics standard, protection will be satisfied across all borders, and the global public will trust researchers. However, defining what needs to be protected and how to define such research standards is very specific to the people to which standards are applied. We suggest that applying one uniform guide cannot accurately protect each individual because we all possess our own perceptions and interpretations of social values. [74] Therefore, the issue of not adjusting to the moral pluralism between peoples in applying one standard of ethics can be resolved by building out ethics models that can be adapted to different cultures and religions.

Other concerns include medical tourism, which may promote health inequities. [75] Some countries may develop and approve products derived from ESC research before others, compromising research ethics or drug approval processes. There are also concerns about the sale of unauthorized stem cell treatments, for example, those without FDA approval in the United States. Countries with robust research infrastructures may be tempted to attract medical tourists, and some customers will have false hopes based on aggressive publicity of unproven treatments. [76]

For example, in China, stem cell clinics can market to foreign clients who are not protected under the regulatory regimes. Companies employ a marketing strategy of “ethically friendly” therapies. Specifically, in the case of Beike, China’s leading stem cell tourism company and sprouting network, ethical oversight of administrators or health bureaus at one site has “the unintended consequence of shifting questionable activities to another node in Beike's diffuse network.” [77] In contrast, Jordan is aware of stem cell research’s potential abuse and its own status as a “health-care hub.” Jordan’s expanded regulations include preserving the interests of individuals in clinical trials and banning private companies from ESC research to preserve transparency and the integrity of research practices. [78]

The social priorities of the community are also a concern. The ISSCR explicitly states that guidelines “should be periodically revised to accommodate scientific advances, new challenges, and evolving social priorities.” [79] The adaptable ethics model extends this consideration further by addressing whether research is warranted given the varying degrees of socioeconomic conditions, political stability, and healthcare accessibilities and limitations. An ethical approach would require discussion about resource allocation and appropriate distribution of funds. [80]

While some religions emphasize the sanctity of life from conception, which may lead to public opposition to ESC research, others encourage ESC research due to its potential for healing and alleviating human pain. Many countries have special regulations that balance local views on embryonic personhood, the benefits of research as individual or societal goods, and the protection of human research subjects. To foster understanding and constructive dialogue, global policy frameworks should prioritize the protection of universal human rights, transparency, and informed consent. In addition to these foundational global policies, we recommend tailoring local guidelines to reflect the diverse cultural and religious perspectives of the populations they govern. Ethics models should be adapted to local populations to effectively establish research protections, growth, and possibilities of stem cell research.

For example, in countries with strong beliefs in the moral sanctity of embryos or heavy religious restrictions, an adaptive model can allow for discussion instead of immediate rejection. In countries with limited individual rights and voice in science policy, an adaptive model ensures cultural, moral, and religious views are taken into consideration, thereby building social inclusion. While this ethical consideration by the government may not give a complete voice to every individual, it will help balance policies and maintain the diverse perspectives of those it affects. Embracing an adaptive ethics model of ESC research promotes open-minded dialogue and respect for the importance of human belief and tradition. By actively engaging with cultural and religious values, researchers can better handle disagreements and promote ethical research practices that benefit each society.

This brief exploration of the religious and cultural differences that impact ESC research reveals the nuances of relative ethics and highlights a need for local policymakers to apply a more intense adaptive model.

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[36] Association for the Advancement of Blood and Biotherapies.  https://www.aabb.org/regulatory-and-advocacy/regulatory-affairs/regulatory-for-cellular-therapies/international-competent-authorities/saudi-arabia

[37] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: Interviews with researchers from Saudi Arabia.  BMC medical ethics ,  21 (1), 35. https://doi.org/10.1186/s12910-020-00482-6

[38] Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: Interviews with researchers from Saudi Arabia. BMC medical ethics , 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6

Culturally, autonomy practices follow a relational autonomy approach based on a paternalistic deontological health care model. The adherence to strict international research policies and religious pillars within the regulatory environment is a great foundation for research ethics. However, there is a need to develop locally targeted ethics approaches for research (as called for in Alahmad, G., Aljohani, S., & Najjar, M. F. (2020). Ethical challenges regarding the use of stem cells: interviews with researchers from Saudi Arabia. BMC medical ethics, 21(1), 35. https://doi.org/10.1186/s12910-020-00482-6), this decision-making approach may help advise a research decision model. For more on the clinical cultural autonomy approaches, see: Alabdullah, Y. Y., Alzaid, E., Alsaad, S., Alamri, T., Alolayan, S. W., Bah, S., & Aljoudi, A. S. (2022). Autonomy and paternalism in Shared decision‐making in a Saudi Arabian tertiary hospital: A cross‐sectional study. Developing World Bioethics , 23 (3), 260–268. https://doi.org/10.1111/dewb.12355 ; Bukhari, A. A. (2017). Universal Principles of Bioethics and Patient Rights in Saudi Arabia (Doctoral dissertation, Duquesne University). https://dsc.duq.edu/etd/124; Ladha, S., Nakshawani, S. A., Alzaidy, A., & Tarab, B. (2023, October 26). Islam and Bioethics: What We All Need to Know . Columbia University School of Professional Studies. https://sps.columbia.edu/events/islam-and-bioethics-what-we-all-need-know

[39] Ababneh, M. A., Al-Azzam, S. I., Alzoubi, K., Rababa’h, A., & Al Demour, S. (2021). Understanding and attitudes of the Jordanian public about clinical research ethics.  Research Ethics ,  17 (2), 228-241.  https://doi.org/10.1177/1747016120966779

[40] Ababneh, M. A., Al-Azzam, S. I., Alzoubi, K., Rababa’h, A., & Al Demour, S. (2021). Understanding and attitudes of the Jordanian public about clinical research ethics.  Research Ethics ,  17 (2), 228-241.  https://doi.org/10.1177/1747016120966779

[41] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[42] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[43] The EU’s definition of autonomy relates to the capacity for creating ideas, moral insight, decisions, and actions without constraint, personal responsibility, and informed consent. However, the EU views autonomy as not completely able to protect individuals and depends on other principles, such as dignity, which “expresses the intrinsic worth and fundamental equality of all human beings.” Rendtorff, J.D., Kemp, P. (2019). Four Ethical Principles in European Bioethics and Biolaw: Autonomy, Dignity, Integrity and Vulnerability. In: Valdés, E., Lecaros, J. (eds) Biolaw and Policy in the Twenty-First Century. International Library of Ethics, Law, and the New Medicine, vol 78. Springer, Cham. https://doi.org/10.1007/978-3-030-05903-3_3

[44] Council of Europe. Convention for the protection of Human Rights and Dignity of the Human Being with regard to the Application of Biology and Medicine: Convention on Human Rights and Biomedicine (ETS No. 164) https://www.coe.int/en/web/conventions/full-list?module=treaty-detail&treatynum=164 (forbidding the creation of embryos for research purposes only, and suggests embryos in vitro have protections.); Also see Drabiak-Syed B. K. (2013). New President, New Human Embryonic Stem Cell Research Policy: Comparative International Perspectives and Embryonic Stem Cell Research Laws in France.  Biotechnology Law Report ,  32 (6), 349–356. https://doi.org/10.1089/blr.2013.9865

[45] Rendtorff, J.D., Kemp, P. (2019). Four Ethical Principles in European Bioethics and Biolaw: Autonomy, Dignity, Integrity and Vulnerability. In: Valdés, E., Lecaros, J. (eds) Biolaw and Policy in the Twenty-First Century. International Library of Ethics, Law, and the New Medicine, vol 78. Springer, Cham. https://doi.org/10.1007/978-3-030-05903-3_3

[46] Tomuschat, C., Currie, D. P., Kommers, D. P., & Kerr, R. (Trans.). (1949, May 23). Basic law for the Federal Republic of Germany. https://www.btg-bestellservice.de/pdf/80201000.pdf

[47] Regulation of Stem Cell Research in Germany . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-germany

[48] Regulation of Stem Cell Research in Finland . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-finland

[49] Regulation of Stem Cell Research in Spain . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-spain

[50] Some sources to consider regarding ethics models or regulatory oversights of other cultures not covered:

Kara MA. Applicability of the principle of respect for autonomy: the perspective of Turkey. J Med Ethics. 2007 Nov;33(11):627-30. doi: 10.1136/jme.2006.017400. PMID: 17971462; PMCID: PMC2598110.

Ugarte, O. N., & Acioly, M. A. (2014). The principle of autonomy in Brazil: one needs to discuss it ...  Revista do Colegio Brasileiro de Cirurgioes ,  41 (5), 374–377. https://doi.org/10.1590/0100-69912014005013

Bharadwaj, A., & Glasner, P. E. (2012). Local cells, global science: The rise of embryonic stem cell research in India . Routledge.

For further research on specific European countries regarding ethical and regulatory framework, we recommend this database: Regulation of Stem Cell Research in Europe . Eurostemcell. (2017, April 26). https://www.eurostemcell.org/regulation-stem-cell-research-europe   

[51] Klitzman, R. (2006). Complications of culture in obtaining informed consent. The American Journal of Bioethics, 6(1), 20–21. https://doi.org/10.1080/15265160500394671 see also: Ekmekci, P. E., & Arda, B. (2017). Interculturalism and Informed Consent: Respecting Cultural Differences without Breaching Human Rights.  Cultura (Iasi, Romania) ,  14 (2), 159–172.; For why trust is important in research, see also: Gray, B., Hilder, J., Macdonald, L., Tester, R., Dowell, A., & Stubbe, M. (2017). Are research ethics guidelines culturally competent?  Research Ethics ,  13 (1), 23-41.  https://doi.org/10.1177/1747016116650235

[52] The Qur'an  (M. Khattab, Trans.). (1965). Al-Mu’minun, 23: 12-14. https://quran.com/23

[53] Lenfest, Y. (2017, December 8). Islam and the beginning of human life . Bill of Health. https://blog.petrieflom.law.harvard.edu/2017/12/08/islam-and-the-beginning-of-human-life/

[54] Aksoy, S. (2005). Making regulations and drawing up legislation in Islamic countries under conditions of uncertainty, with special reference to embryonic stem cell research. Journal of Medical Ethics , 31: 399-403.; see also: Mahmoud, Azza. "Islamic Bioethics: National Regulations and Guidelines of Human Stem Cell Research in the Muslim World." Master's thesis, Chapman University, 2022. https://doi.org/10.36837/ chapman.000386

[55] Rashid, R. (2022). When does Ensoulment occur in the Human Foetus. Journal of the British Islamic Medical Association , 12 (4). ISSN 2634 8071. https://www.jbima.com/wp-content/uploads/2023/01/2-Ethics-3_-Ensoulment_Rafaqat.pdf.

[56] Sivaraman, M. & Noor, S. (2017). Ethics of embryonic stem cell research according to Buddhist, Hindu, Catholic, and Islamic religions: perspective from Malaysia. Asian Biomedicine,8(1) 43-52.  https://doi.org/10.5372/1905-7415.0801.260

[57] Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

[58] Lecso, P. A. (1991). The Bodhisattva Ideal and Organ Transplantation.  Journal of Religion and Health ,  30 (1), 35–41. http://www.jstor.org/stable/27510629 ; Bodhisattva, S. (n.d.). The Key of Becoming a Bodhisattva . A Guide to the Bodhisattva Way of Life. http://www.buddhism.org/Sutras/2/BodhisattvaWay.htm

[59] There is no explicit religious reference to when life begins or how to conduct research that interacts with the concept of life. However, these are relevant verses pertaining to how the fetus is viewed. (( King James Bible . (1999). Oxford University Press. (original work published 1769))

Jerimiah 1: 5 “Before I formed thee in the belly I knew thee; and before thou camest forth out of the womb I sanctified thee…”

In prophet Jerimiah’s insight, God set him apart as a person known before childbirth, a theme carried within the Psalm of David.

Psalm 139: 13-14 “…Thou hast covered me in my mother's womb. I will praise thee; for I am fearfully and wonderfully made…”

These verses demonstrate David’s respect for God as an entity that would know of all man’s thoughts and doings even before birth.

[60] It should be noted that abortion is not supported as well.

[61] The Vatican. (1987, February 22). Instruction on Respect for Human Life in Its Origin and on the Dignity of Procreation Replies to Certain Questions of the Day . Congregation For the Doctrine of the Faith. https://www.vatican.va/roman_curia/congregations/cfaith/documents/rc_con_cfaith_doc_19870222_respect-for-human-life_en.html

[62] The Vatican. (2000, August 25). Declaration On the Production and the Scientific and Therapeutic Use of Human Embryonic Stem Cells . Pontifical Academy for Life. https://www.vatican.va/roman_curia/pontifical_academies/acdlife/documents/rc_pa_acdlife_doc_20000824_cellule-staminali_en.html ; Ohara, N. (2003). Ethical Consideration of Experimentation Using Living Human Embryos: The Catholic Church’s Position on Human Embryonic Stem Cell Research and Human Cloning. Department of Obstetrics and Gynecology . Retrieved from https://article.imrpress.com/journal/CEOG/30/2-3/pii/2003018/77-81.pdf.

[63] Smith, G. A. (2022, May 23). Like Americans overall, Catholics vary in their abortion views, with regular mass attenders most opposed . Pew Research Center. https://www.pewresearch.org/short-reads/2022/05/23/like-americans-overall-catholics-vary-in-their-abortion-views-with-regular-mass-attenders-most-opposed/

[64] Rosner, F., & Reichman, E. (2002). Embryonic stem cell research in Jewish law. Journal of halacha and contemporary society , (43), 49–68.; Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

[65] Schenker J. G. (2008). The beginning of human life: status of embryo. Perspectives in Halakha (Jewish Religious Law).  Journal of assisted reproduction and genetics ,  25 (6), 271–276. https://doi.org/10.1007/s10815-008-9221-6

[66] Ruttenberg, D. (2020, May 5). The Torah of Abortion Justice (annotated source sheet) . Sefaria. https://www.sefaria.org/sheets/234926.7?lang=bi&with=all&lang2=en

[67] Jafari, M., Elahi, F., Ozyurt, S. & Wrigley, T. (2007). 4. Religious Perspectives on Embryonic Stem Cell Research. In K. Monroe, R. Miller & J. Tobis (Ed.),  Fundamentals of the Stem Cell Debate: The Scientific, Religious, Ethical, and Political Issues  (pp. 79-94). Berkeley: University of California Press.  https://escholarship.org/content/qt9rj0k7s3/qt9rj0k7s3_noSplash_f9aca2e02c3777c7fb76ea768ba458f0.pdf https://doi.org/10.1525/9780520940994-005

[68] Gert, B. (2007). Common morality: Deciding what to do . Oxford Univ. Press.

[69] World Medical Association (2013). World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA , 310(20), 2191–2194. https://doi.org/10.1001/jama.2013.281053 Declaration of Helsinki – WMA – The World Medical Association .; see also: National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. (1979).  The Belmont report: Ethical principles and guidelines for the protection of human subjects of research . U.S. Department of Health and Human Services.  https://www.hhs.gov/ohrp/regulations-and-policy/belmont-report/read-the-belmont-report/index.html

[70] Zakarin Safier, L., Gumer, A., Kline, M., Egli, D., & Sauer, M. V. (2018). Compensating human subjects providing oocytes for stem cell research: 9-year experience and outcomes.  Journal of assisted reproduction and genetics ,  35 (7), 1219–1225. https://doi.org/10.1007/s10815-018-1171-z https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063839/ see also: Riordan, N. H., & Paz Rodríguez, J. (2021). Addressing concerns regarding associated costs, transparency, and integrity of research in recent stem cell trial. Stem Cells Translational Medicine , 10 (12), 1715–1716. https://doi.org/10.1002/sctm.21-0234

[71] Klitzman, R., & Sauer, M. V. (2009). Payment of egg donors in stem cell research in the USA.  Reproductive biomedicine online ,  18 (5), 603–608. https://doi.org/10.1016/s1472-6483(10)60002-8

[72] Krosin, M. T., Klitzman, R., Levin, B., Cheng, J., & Ranney, M. L. (2006). Problems in comprehension of informed consent in rural and peri-urban Mali, West Africa.  Clinical trials (London, England) ,  3 (3), 306–313. https://doi.org/10.1191/1740774506cn150oa

[73] Veatch, Robert M.  Hippocratic, Religious, and Secular Medical Ethics: The Points of Conflict . Georgetown University Press, 2012.

[74] Msoroka, M. S., & Amundsen, D. (2018). One size fits not quite all: Universal research ethics with diversity.  Research Ethics ,  14 (3), 1-17.  https://doi.org/10.1177/1747016117739939

[75] Pirzada, N. (2022). The Expansion of Turkey’s Medical Tourism Industry.  Voices in Bioethics ,  8 . https://doi.org/10.52214/vib.v8i.9894

[76] Stem Cell Tourism: False Hope for Real Money . Harvard Stem Cell Institute (HSCI). (2023). https://hsci.harvard.edu/stem-cell-tourism , See also: Bissassar, M. (2017). Transnational Stem Cell Tourism: An ethical analysis.  Voices in Bioethics ,  3 . https://doi.org/10.7916/vib.v3i.6027

[77] Song, P. (2011) The proliferation of stem cell therapies in post-Mao China: problematizing ethical regulation,  New Genetics and Society , 30:2, 141-153, DOI:  10.1080/14636778.2011.574375

[78] Dajani, R. (2014). Jordan’s stem-cell law can guide the Middle East.  Nature  510, 189. https://doi.org/10.1038/510189a

[79] International Society for Stem Cell Research. (2024). Standards in stem cell research . International Society for Stem Cell Research. https://www.isscr.org/guidelines/5-standards-in-stem-cell-research

[80] Benjamin, R. (2013). People’s science bodies and rights on the Stem Cell Frontier . Stanford University Press.

Olivia Bowers

MS Bioethics Columbia University (Disclosure: affiliated with Voices in Bioethics)

Mifrah Hayath

SM Candidate Harvard Medical School, MS Biotechnology Johns Hopkins University

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