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Theses & Dissertations: Cancer Research

Theses/dissertations from 2024 2024.

Novel Spirocyclic Dimer (SpiD3) Displays Potent Preclinical Effects in Hematological Malignancies , Alexandria Eiken

Therapeutic Effects of BET Protein Inhibition in B-cell Malignancies and Beyond , Audrey L. Smith

Identifying the Molecular Determinants of Lung Metastatic Adaptation in Prostate Cancer , Grace M. Waldron

Identification of Mitotic Phosphatases and Cyclin K as Novel Molecular Targets in Pancreatic Cancer , Yi Xiao

Theses/Dissertations from 2023 2023

Development of Combination Therapy Strategies to Treat Cancer Using Dihydroorotate Dehydrogenase Inhibitors , Nicholas Mullen

Overcoming Resistance Mechanisms to CDK4/6 Inhibitor Treatment Using CDK6-Selective PROTAC , Sarah Truong

Theses/Dissertations from 2022 2022

Omics Analysis in Cancer and Development , Emalie J. Clement

Investigating the Role of Splenic Macrophages in Pancreatic Cancer , Daisy V. Gonzalez

Polymeric Chloroquine in Metastatic Pancreatic Cancer Therapy , Rubayat Islam Khan

Evaluating Targets and Therapeutics for the Treatment of Pancreatic Cancer , Shelby M. Knoche

Characterization of 1,1-Diarylethylene FOXM1 Inhibitors Against High-Grade Serous Ovarian Carcinoma Cells , Cassie Liu

Novel Mechanisms of Protein Kinase C α Regulation and Function , Xinyue Li

SOX2 Dosage Governs Tumor Cell Identity and Proliferation , Ethan P. Metz

Post-Transcriptional Control of the Epithelial-to-Mesenchymal Transition (EMT) in Ras-Driven Colorectal Cancers , Chaitra Rao

Use of Machine Learning Algorithms and Highly Multiplexed Immunohistochemistry to Perform In-Depth Characterization of Primary Pancreatic Tumors and Metastatic Sites , Krysten Vance

Characterization of Metastatic Cutaneous Squamous Cell Carcinoma in the Immunosuppressed Patient , Megan E. Wackel

Visceral adipose tissue remodeling in pancreatic ductal adenocarcinoma cachexia: the role of activin A signaling , Pauline Xu

Phos-Tag-Based Screens Identify Novel Therapeutic Targets in Ovarian Cancer and Pancreatic Cancer , Renya Zeng

Theses/Dissertations from 2021 2021

Functional Characterization of Cancer-Associated DNA Polymerase ε Variants , Stephanie R. Barbari

Pancreatic Cancer: Novel Therapy, Research Tools, and Educational Outreach , Ayrianne J. Crawford

Apixaban to Prevent Thrombosis in Adult Patients Treated With Asparaginase , Krishna Gundabolu

Molecular Investigation into the Biologic and Prognostic Elements of Peripheral T-cell Lymphoma with Regulators of Tumor Microenvironment Signaling Explored in Model Systems , Tyler Herek

Utilizing Proteolysis-Targeting Chimeras to Target the Transcriptional Cyclin-Dependent Kinases 9 and 12 , Hannah King

Insights into Cutaneous Squamous Cell Carcinoma Pathogenesis and Metastasis Using a Bedside-to-Bench Approach , Marissa Lobl

Development of a MUC16-Targeted Near-Infrared Antibody Probe for Fluorescence-Guided Surgery of Pancreatic Cancer , Madeline T. Olson

FGFR4 glycosylation and processing in cholangiocarcinoma promote cancer signaling , Andrew J. Phillips

Theses/Dissertations from 2020 2020

Cooperativity of CCNE1 and FOXM1 in High-Grade Serous Ovarian Cancer , Lucy Elge

Characterizing the critical role of metabolic and redox homeostasis in colorectal cancer , Danielle Frodyma

Genomic and Transcriptomic Alterations in Metabolic Regulators and Implications for Anti-tumoral Immune Response , Ryan J. King

Dimers of Isatin Derived Spirocyclic NF-κB Inhibitor Exhibit Potent Anticancer Activity by Inducing UPR Mediated Apoptosis , Smit Kour

From Development to Therapy: A Panoramic Approach to Further Our Understanding of Cancer , Brittany Poelaert

The Cellular Origin and Molecular Drivers of Claudin-Low Mammary Cancer , Patrick D. Raedler

Mitochondrial Metabolism as a Therapeutic Target for Pancreatic Cancer , Simon Shin

Development of Fluorescent Hyaluronic Acid Nanoparticles for Intraoperative Tumor Detection , Nicholas E. Wojtynek

Theses/Dissertations from 2019 2019

The role of E3 ubiquitin ligase FBXO9 in normal and malignant hematopoiesis , R. Willow Hynes-Smith

BRCA1 & CTDP1 BRCT Domainomics in the DNA Damage Response , Kimiko L. Krieger

Targeted Inhibition of Histone Deacetyltransferases for Pancreatic Cancer Therapy , Richard Laschanzky

Human Leukocyte Antigen (HLA) Class I Molecule Components and Amyloid Precursor-Like Protein 2 (APLP2): Roles in Pancreatic Cancer Cell Migration , Bailee Sliker

Theses/Dissertations from 2018 2018

FOXM1 Expression and Contribution to Genomic Instability and Chemoresistance in High-Grade Serous Ovarian Cancer , Carter J. Barger

Overcoming TCF4-Driven BCR Signaling in Diffuse Large B-Cell Lymphoma , Keenan Hartert

Functional Role of Protein Kinase C Alpha in Endometrial Carcinogenesis , Alice Hsu

Functional Signature Ontology-Based Identification and Validation of Novel Therapeutic Targets and Natural Products for the Treatment of Cancer , Beth Neilsen

Elucidating the Roles of Lunatic Fringe in Pancreatic Ductal Adenocarcinoma , Prathamesh Patil

Theses/Dissertations from 2017 2017

Metabolic Reprogramming of Pancreatic Ductal Adenocarcinoma Cells in Response to Chronic Low pH Stress , Jaime Abrego

Understanding the Relationship between TGF-Beta and IGF-1R Signaling in Colorectal Cancer , Katie L. Bailey

The Role of EHD2 in Triple-Negative Breast Cancer Tumorigenesis and Progression , Timothy A. Bielecki

Perturbing anti-apoptotic proteins to develop novel cancer therapies , Jacob Contreras

Role of Ezrin in Colorectal Cancer Cell Survival Regulation , Premila Leiphrakpam

Evaluation of Aminopyrazole Analogs as Cyclin-Dependent Kinase Inhibitors for Colorectal Cancer Therapy , Caroline Robb

Identifying the Role of Janus Kinase 1 in Mammary Gland Development and Breast Cancer , Barbara Swenson

DNMT3A Haploinsufficiency Provokes Hematologic Malignancy of B-Lymphoid, T-Lymphoid, and Myeloid Lineage in Mice , Garland Michael Upchurch

Theses/Dissertations from 2016 2016

EHD1 As a Positive Regulator of Macrophage Colony-Stimulating Factor-1 Receptor , Luke R. Cypher

Inflammation- and Cancer-Associated Neurolymphatic Remodeling and Cachexia in Pancreatic Ductal Adenocarcinoma , Darci M. Fink

Role of CBL-family Ubiquitin Ligases as Critical Negative Regulators of T Cell Activation and Functions , Benjamin Goetz

Exploration into the Functional Impact of MUC1 on the Formation and Regulation of Transcriptional Complexes Containing AP-1 and p53 , Ryan L. Hanson

DNA Polymerase Zeta-Dependent Mutagenesis: Molecular Specificity, Extent of Error-Prone Synthesis, and the Role of dNTP Pools , Olga V. Kochenova

Defining the Role of Phosphorylation and Dephosphorylation in the Regulation of Gap Junction Proteins , Hanjun Li

Molecular Mechanisms Regulating MYC and PGC1β Expression in Colon Cancer , Jamie L. McCall

Pancreatic Cancer Invasion of the Lymphatic Vasculature and Contributions of the Tumor Microenvironment: Roles for E-selectin and CXCR4 , Maria M. Steele

Altered Levels of SOX2, and Its Associated Protein Musashi2, Disrupt Critical Cell Functions in Cancer and Embryonic Stem Cells , Erin L. Wuebben

Theses/Dissertations from 2015 2015

Characterization and target identification of non-toxic IKKβ inhibitors for anticancer therapy , Elizabeth Blowers

Effectors of Ras and KSR1 dependent colon tumorigenesis , Binita Das

Characterization of cancer-associated DNA polymerase delta variants , Tony M. Mertz

A Role for EHD Family Endocytic Regulators in Endothelial Biology , Alexandra E. J. Moffitt

Biochemical pathways regulating mammary epithelial cell homeostasis and differentiation , Chandrani Mukhopadhyay

EPACs: epigenetic regulators that affect cell survival in cancer. , Catherine Murari

Role of the C-terminus of the Catalytic Subunit of Translesion Synthesis Polymerase ζ (Zeta) in UV-induced Mutagensis , Hollie M. Siebler

LGR5 Activates TGFbeta Signaling and Suppresses Metastasis in Colon Cancer , Xiaolin Zhou

LGR5 Activates TGFβ Signaling and Suppresses Metastasis in Colon Cancer , Xiaolin Zhou

Theses/Dissertations from 2014 2014

Genetic dissection of the role of CBL-family ubiquitin ligases and their associated adapters in epidermal growth factor receptor endocytosis , Gulzar Ahmad

Strategies for the identification of chemical probes to study signaling pathways , Jamie Leigh Arnst

Defining the mechanism of signaling through the C-terminus of MUC1 , Roger B. Brown

Targeting telomerase in human pancreatic cancer cells , Katrina Burchett

The identification of KSR1-like molecules in ras-addicted colorectal cancer cells , Drew Gehring

Mechanisms of regulation of AID APOBEC deaminases activity and protection of the genome from promiscuous deamination , Artem Georgievich Lada

Characterization of the DNA-biding properties of human telomeric proteins , Amanda Lakamp-Hawley

Studies on MUC1, p120-catenin, Kaiso: coordinate role of mucins, cell adhesion molecules and cell cycle players in pancreatic cancer , Xiang Liu

Epac interaction with the TGFbeta PKA pathway to regulate cell survival in colon cancer , Meghan Lynn Mendick

Theses/Dissertations from 2013 2013

Deconvolution of the phosphorylation patterns of replication protein A by the DNA damage response to breaks , Kerry D. Brader

Modeling malignant breast cancer occurrence and survival in black and white women , Michael Gleason

The role of dna methyltransferases in myc-induced lymphomagenesis , Ryan A. Hlady

Design and development of inhibitors of CBL (TKB)-protein interactions , Eric A. Kumar

Pancreatic cancer-associated miRNAs : expression, regulation and function , Ashley M. Mohr

Mechanistic studies of mitochondrial outer membrane permeabilization (MOMP) , Xiaming Pang

Novel roles for JAK2/STAT5 signaling in mammary gland development, cancer, and immune dysregulation , Jeffrey Wayne Schmidt

Optimization of therapeutics against lethal pancreatic cancer , Joshua J. Souchek

Theses/Dissertations from 2012 2012

Immune-based novel diagnostic mechanisms for pancreatic cancer , Michael J. Baine

Sox2 associated proteins are essential for cell fate , Jesse Lee Cox

KSR2 regulates cellular proliferation, transformation, and metabolism , Mario R. Fernandez

Discovery of a novel signaling cross-talk between TPX2 and the aurora kinases during mitosis , Jyoti Iyer

Regulation of metabolism by KSR proteins , Paula Jean Klutho

The role of ERK 1/2 signaling in the dna damage-induced G2 , Ryan Kolb

Regulation of the Bcl-2 family network during apoptosis induced by different stimuli , Hernando Lopez

Studies on the role of cullin3 in mitosis , Saili Moghe

Characteristics of amyloid precursor-like protein 2 (APLP2) in pancreatic cancer and Ewing's sarcoma , Haley Louise Capek Peters

Structural and biophysical analysis of a human inosine triphosphate pyrophosphatase polymorphism , Peter David Simone

Functions and regulation of Ron receptor tyrosine kinase in human pancreatic cancer and its therapeutic applications , Yi Zou

Theses/Dissertations from 2011 2011

Coordinate detection of new targets and small molecules for cancer therapy , Kurt Fisher

The role of c-Myc in pancreatic cancer initiation and progression , Wan-Chi Lin

The role of inosine triphosphate pyrophosphatase (ITPA) in maintanence [sic] of genomic stability in human cells , Miriam-Rose Menezes

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Student theses

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A biologically-inspired artificial lateral line: observations of collective behaviour in fish lead to the development of a novel design of simple and low-cost artificial lateral line sensor.

Supervisor: Hauert, S. (Supervisor), Ioannou, C. (Supervisor) & Genner, M. J. (Supervisor)

Student thesis : Doctoral Thesis › Doctor of Philosophy (PhD)

A characterisation of mononuclear phagocyte dynamics in the healthy and regenerating zebrafish heart

Supervisor: Richardson, B. (Supervisor) & Martin, P. B. (Supervisor)

A Computational Framework for the Optimisation of Antivenom Pharmacokinetics and Pharmacodynamics

Supervisor: Hauert, S. (Supervisor), Blee, J. A. (Supervisor) & Collinson, I. R. (Supervisor)

An Epigenome-Wide Association Study of Eczema

Supervisor: Paternoster, L. (Supervisor), Elliott, H. (Supervisor) & Relton, C. (Supervisor)

Student thesis : Master's Thesis › Master of Science by Research (MScR)

An Investigation into the Link Between Sleep and Alzheimer’s Disease Using a Multi-Method Approach

Supervisor: Coulthard, E. J. (Supervisor) & Ben-Shlomo, Y. (Supervisor)

Applications of HS-AFM Imaging to Marine Microbial Life and its Environment

Supervisor: Day, J. C. C. (Supervisor), Picco, L. M. (Supervisor), Payton, O. D. (Supervisor) & Allen, M. (Supervisor)

Applying ‘omics to understand and predict juvenile idiopathic arthritis

Supervisor: Relton, C. (Supervisor), Ramanan, A. (Supervisor), Sharp, G. (Supervisor) & Zhou, Y. (External person) (Supervisor)

Appraising the causal relationship between DNA methylation and type 2 diabetes

Supervisor: Elliott, H. (Supervisor), Relton, C. (Supervisor) & Sharp, G. (Supervisor)

A qualitative exploration of recruiters' and patients' perspectives and experiences of the recruitment encounter in randomised controlled trials

Supervisor: Young, B. (Supervisor), Rooshenas, L. (Supervisor), Elliott, D. (Supervisor), Jepson, M. (Supervisor) & Donovan , J. L. (Supervisor)

Arole for IGFBP-2 in DNA repair in breast cancer cells

Supervisor: Perks, C. (Supervisor), Holly, J. (Supervisor) & Biernacka, K. M. (Supervisor)

Assessing the feasibility of dietary restriction, including short-term fasting, at the time of chemotherapy

Supervisor: Atkinson, C. (Supervisor), Herbert, G. (Supervisor), Ness, A. (Supervisor) & Perks, C. (Supervisor)

A study of hyperspectral reflectance and fluorescence imaging as alternative Methods for assessing coral health

Supervisor: Day, J. (Supervisor) & Scott, T. (Supervisor)

Biological and lifestyle predictors of survival in head and neck cancer.

Supervisor: Dos Santos Ferreira, D. (Supervisor), Ingle, S. (Supervisor), Ness, A. (Supervisor), Martin, R. (Supervisor) & May, M. T. (Supervisor)

Biosynthetic Studies on Kalimantacin Antibiotics

Supervisor: Willis, C. L. (Supervisor) & Crump, M. P. (Supervisor)

Capturing complexity, comorbidity and frailty in people with parkinsonism and understanding their impact

Supervisor: Ben-Shlomo, Y. (Supervisor) & Henderson, E. (Supervisor)

Causal implications of common infections and platelet function on cardiovascular disease

Supervisor: Paternoster, L. (Supervisor), Richmond, R. (Supervisor), Davey Smith, G. (Supervisor) & Poole, A. (Supervisor)

Causal pathways from cognitive ability to Alzheimer's disease

Supervisor: Davies, N. M. (Supervisor), Anderson, E. L. (Supervisor), Howe, L. D. (Supervisor) & Ben-Shlomo, Y. (Supervisor)

Characterisation of Ataxia Telangiectasia Mutated in RPE-1 cells and its role in cellular sensitivity to hypo-osmotic stress

Supervisor: Mellor, H. H. (Supervisor) & Wood, W. J. (Supervisor)

Characterisation of the cellular compartments containing inhibitory receptors in CD8 + T cells

Supervisor: Wuelfing, C. (Supervisor) & Morgan, D. (Supervisor)

Characterisation of the HELLS and Irc5 subfamily of chromatin remodellers

Supervisor: Dillingham, M. (Supervisor) & Chambers, A. (Supervisor)

Characterising Red Cell-Derived Vesicles in Sickle Cell Disease and Investigating Potential to Induce Tolerance to Human Red Cell Antigens

Supervisor: Blair, A. (Supervisor) & Anstee, D. J. (Supervisor)

Complex trait architecture through the lens of epigenome-wide association studies

Supervisor: Gaunt, T. (Supervisor), Hemani, G. (Supervisor) & Timpson, N. J. (Supervisor)

Decentralised Algorithms for Area Coverage

Supervisor: Ganesh, A. (Supervisor) & Hauert, S. (Supervisor)

Dental care pathways and parent-reported dental outcomes for 5-year-old children born with a cleft in the UK

Supervisor: Fowler, P. V. (Supervisor), Leary, S. D. (Supervisor), Wren, Y. E. (Supervisor) & Williams, J. (Supervisor)

Student thesis : Doctoral Thesis › Doctor of Dental Surgery (DDS)

Diabetes mellitus causes adiposopathy in bone marrow: investigation of the underpinning cellular and molecular mechanisms

Supervisor: Madeddu, P. (Supervisor) & Mellor, H. H. (Supervisor)

Does the association between later eating rhythm and childhood adiposity differ between the UK and China?

Supervisor: Leary, S. D. (Supervisor) & Northstone, K. (Supervisor)

Does the IGF axis influence EMT to play a role in bladder cancer progression?

Supervisor: Perks, C. (Supervisor) & Holly, J. M. P. (Supervisor)

Elucidating mechanisms of tumour resistance to checkpoint blockade

Supervisor: Wooldridge, L. (Supervisor), Morgan, D. (Supervisor) & Wuelfing, C. (Supervisor)

Enhanced numerical techniques for time domain electromagnetic analysis

Evaluation of a primary care epilepsy specialist nurse service.

Supervisor: Bachmann, M. (Supervisor)

Evaluation of Cardiopulmonary Exercise Testing (CPET) as a Prognostic Tool in Idiopathic Pulmonary Fibrosis (IPF)

Supervisor: Maskell, N. (Supervisor) & Millar, A. (Supervisor)

Evolving Morphological Adaption Methods in Compliant Robots

Supervisor: Hauser, H. (Supervisor) & Hauert, S. (Supervisor)

Examining the Role of Placental-derived MicroRNA Secretions in Response to Gestational Hypoxia on Foetal Neurodevelopment

Supervisor: Case, C. P. (Supervisor), Perks, C. M. (Supervisor), Uney, J. B. (Supervisor) & Fulga, T. A. (External person) (Supervisor)

Expertise during surgical innovation: advancing understanding about non-technical skills and related optimisation factors

Supervisor: Mills, N. (Supervisor), Blencowe, N. (Supervisor) & Blazeby, J. (Supervisor)

Exploring the effect of adiposity on platelet function and related pathways: implications for cardiovascular disease

Supervisor: Timpson, N. (Supervisor) & Hers, I. (Supervisor)

Exploring the in vitro behaviour of endothelial cells in different cell culture models

Supervisor: Mellor, H. (Supervisor) & Gaston, K. (Supervisor)

Exploring the microclot-driven pre-metastatic niche: live imaging studies in zebrafish larvae

Supervisor: Martin, P. B. (Supervisor) & Nobes, C. D. (Supervisor)

Exploring the role of BCL-3 in colorectal cancer cell therapeutic resistance

Supervisor: Martin, P. (Supervisor), Cullen, P. (Supervisor) & Williams, A. (Supervisor)

Extra-pulmonary effects of lung function and lung disease

Supervisor: Davey Smith, G. (Supervisor), Dodd, J. (Supervisor) & Granell, R. (Supervisor)

Fatty acid construction within the biosynthesis of the polyketide antibiotic mupirocin

Supervisor: Crump, M. P. (Supervisor), Willis, C. (External person) (Supervisor) & Race, P. R. (Supervisor)

Feeding and Autoimmunity in Children with Down’s Syndrome Evaluation Study (FADES)

Supervisor: Hamilton-Shield, J. P. (Supervisor), Gillespie, K. M. (Supervisor) & Leary, S. D. (Supervisor)

From peptide oligomers to single-chain proteins

Supervisor: Woolfson, D. (Supervisor) & Crump, M. (Supervisor)

Genetic and Environmental Contributions to Trajectories of Depressive Symptoms

Supervisor: Manley, D. (Supervisor), Timpson, N. J. (Supervisor) & Leckie, G. (Supervisor)

Genetic and epidemiologic approaches to elucidate the role of abnormal hip shape in the development of hip osteoarthritis

Supervisor: Davey Smith, G. (Supervisor) & Tobias, J. (Supervisor)

Genetic and epigenetic data as a tool to augment understanding of oropharyngeal cancer

Supervisor: Relton, C. L. (Supervisor), Thomas, S. J. (Supervisor), Richmond, R. C. (Supervisor) & Elliott, H. R. (Supervisor)

Geographical gene-environment interaction and correlation for mental health in the UK and Sweden

Supervisor: Davis, O. S. (Supervisor) & Davey Smith, G. (Supervisor)

Glial autophagy capability and the control of neuroinflammatory signaling in Parkinson’s disease.

Supervisor: Lane, J. D. (Supervisor) & Carroll, B. M. (Supervisor)

'Hi-Fi Nanoscience' : Exploring the nanoscale with optical pickup units

Supervisor: Payton, O. D. (Supervisor) & Day, J. C. C. (Supervisor)

High-throughput proteomic analysis of the dengue virus secretome and the identification of plasma biomarkers of disease severity

Supervisor: Morgan, D. (Supervisor) & Davidson, A. (Supervisor)

Identification of Protein Disulphide-Isomerase A3 Dependent Proteins from the Secretome of MDA-MB-231 Breast Cancer Cells

Supervisor: Adams, J. (Supervisor)

UKnowledge > College of Medicine > Toxicology and Cancer Biology > Theses & Dissertations

Theses and Dissertations--Toxicology and Cancer Biology

Theses/dissertations from 2024 2024.

UNDERSTANDING THE MECHANISM OF FERROPTOSIS SUSCEPTIBILITY VARIATION IN COLORECTAL CANCER , Aziza Alshahrani

Elucidation of Mismatch Repair Regulation by ABL1: Advantages/Disadvantages of Tyrosine Kinase Inhibitor Treatment , Hannah Daniels

ACQUIRED TREATMENT RESISTANCE IN PROSTATE CANCER VIA THE PRODUCTION OF RADIATION DERIVED EXTRACELLULAR VESICLES CONTAINING MITOCHONDRIAL PROTEINS , Caitlin Miller

Theses/Dissertations from 2023 2023

ELUCIDATING THE FUNCTIONAL IMPORTANCE OF PEROXIREDOXIN IV IN PROSTATE CANCER AND ITS SECRETION MECHANISM , Na Ding

Targeting EZH2 to Improve Outcomes of Lung Squamous Cell Carcinoma , Tanner DuCote

UNDERSTANDING AND TARGETING THE TPH1-SEROTONIN-HTR3A AXIS IN SMALL CELL LUNG CANCER , Yanning Hao

CONSERVED NOVEL INTERACTIONS BETWEEN POST-REPLICATIVE REPAIR AND MISMATCH REPAIR PROTEINS HAVE DIFFERENTIAL EFFECTS ON DNA REPAIR PATHWAYS , Anna K. Miller

UNDERSTANDING THE ROLE OF PEROXIREDOXIN IV IN COLORECTAL CANCER DEVELOPMENT , Pratik Thapa

BEYOND MITOSIS, PLK1-MEDIATED PHOSPHORYLATION RE-WIRES CANCER METABOLISM AND PROMOTES CANCER PROGRESSION , Qiongsi Zhang

Theses/Dissertations from 2022 2022

ELUCIDATING THE ROLE OF POLYCOMB REPRESSIVE COMPLEX 2 IN LUNG STEM CELL FATE AND LUNG DISEASE , Aria Byrd

SEX DIMORPHISM IN HEMATOPOIESIS AND BONE MARROW NICHE , xiaojing cui

EXTRACELLULAR VESICLES AND CANCER THERAPY: AN INSIGHT INTO THE ROLE OF OXIDATIVE STRESS , Jenni Ho

OVERCOMING RESISTANCE TO SG-ARIS IN CASTRATION-RESISTANT PROSTATE CANCER , Chaohao Li

Theses/Dissertations from 2021 2021

THE TUMOR SUPPRESSOR PAR-4 REGULATES HYPERTROPHIC OBESITY , Nathalia Araujo

Epigenetic States Regulate Tumor Aggressiveness and Response to Targeted Therapies in Lung Adenocarcinoma , Fan Chen

DELINEATING THE ROLE OF FATTY ACID METABOLISM TO IMPROVE THERAPEUTIC STRATEGIES FOR COLORECTAL CANCER , James Drury

DEVELOPMENT OF TOOLS FOR ATOM-LEVEL INTERPRETATION OF STABLE ISOTOPE-RESOLVED METABOLOMICS DATASETS , Huan Jin

MECHANISMS OF CADMIUM-INDUCED AND EPIDERMAL GROWTH FACTOR RECEPTOR MUTATION-DRIVEN LUNG TUMORIGENESIS , Hsuan-Pei Lin

SCIENCE-BASED REGULATION OF PHARMACOLOGICAL SUBSTANCES IN COMPETITION HORSES , Jacob Machin

A NOVEL ROLE FOR NEUROTENSIN IN REGULATION OF STEM CELL FUNCTION IN THE SMALL INTESTINE , Stephanie Rock

Theses/Dissertations from 2020 2020

NOVEL POST-TRANSLATIONAL MODIFICATION AND FUNCTION OF FUS: THE RELEVANCE TO AMYOTROPHIC LATERAL SCLEROSIS , Alexandra Arenas

Prostate Cancer Resistance to Cabazitaxel Chemotherapy , Diane Begemann

Examining the Role of Metabolic Pathways as Therapeutic Modalities for Triple Negative Breast Cancer , Jeremy Andrew Johnson

THE ROLE OF NEURAL PRECURSOR CELL EXPRESSED DEVELOPMENTALLY DOWN-REGULATED PROTEIN 9 IN ENHANCED AGGRESSIVENESS OF HEXAVALENT CHROMIUM TRANSFORMED BRONCHIAL EPITHELIAL CELLS , Peter Van Wie

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Identifying prognostic biomarkers for cancer using gene expression data

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Intratumor Heterogeneity Drives the Evolution of Multiple Populations with Metastatic Initiating Capabilities in a Genetically Engineered Mouse Model of Triple Negative Breast Cancer 

The Molecular Mechanisms Underlying the Pathophysiological Role of Membrane-Bound Proteolysis in Human Skin 

Epigenetic Regulation in Cancers: PRMT1-Driven Development of Gemcitabine Resistance through Modulation of MAFF/BACH1 Chromatin Dynamics in Pancreatic Ductal Adenocarcinoma (PDAC) 

Effects of CDK4/6 Inhibitor-Induced Stromal Senescence on the Metastatic Niche and Metastasis of Breast Cancer 

The Integration of TGFβ and Egfr Signaling Programs Confers the Ability to Lead Heterogeneous Collective Invasion 

IMPACT OF THE BREAST CANCER IMMUNE MICROENVIRONMENT ON RACIAL DISPARITIES AND RECURRENCE

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• Affiliation: School of Medicine, Department of Pathology and Laboratory Medicine
• Growing evidence supports the importance of the immune microenvironment in the clinical course of breast cancer, where multiple studies have demonstrated positive prognostic utility of tumor infiltrating lymphocytes among triple-negative and HER2-positive breast cancers. Despite the abundance of studies investigating the immune microenvironment in breast cancer, biomarkers of immune response are lacking, particularly in estrogen receptor (ER)-positive breast cancer, and Black women are underrepresented in these studies. This is important because Black women suffer higher incidence of poor-prognosis subtypes and worse stage-specific mortality. Given the rapidly evolving landscape of immunotherapies in breast cancer and ongoing efforts to expand currently limited treatment eligibility, investigations of the breast cancer immune microenvironment and identification of biomarkers that associate with immune-mediated survival in diverse patient populations, is an unmet clinical need. To address this knowledge gap, the current body of work leveraged three major breast cancer studies rich in molecular, histological, clinical and epidemiological data: 1) the Carolina Breast Cancer Study (CBCS; N= 1,952), a large population-based study designed to investigate racial disparities in breast cancer, 2) The Cancer Genome Atlas (TCGA) breast cancer dataset (N= 1,095), a well-known study with multiple data platforms for each sample, and 3) the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) dataset (N= 1,904). Aim 1 of this study characterized global phenotypes of immune response using cell-type specific markers for 10 immune cell populations and evaluated associations with clinical and demographic variables, and recurrence. Aim 2 leveraged RNA expression profiling to investigate markers of genomic instability in association with breast cancer immunogenicity and immune-mediated patterns of recurrence. This work identified strong associations between phenotypes of immune response and tumor subtype, grade, patient age, BMI and self-reported race. In addition, RNA-based pathway assessment of genomic instability markers (HRD, APOBEC, and TP53 pathways) identified immunogenic tumors with strong adaptive immune responses that associated with recurrence-free survival regardless of ER status. Collectively, this work contributes novel findings about the breast cancer immune microenvironment that may aid in precision medicine approaches for breast cancer prevention and intervention, and highlights the importance of diversity in impactful and equitable clinical research.
• breast cancer
• immune microenvironment
• Epidemiology
• disparities
• genomic instability
• https://doi.org/10.17615/t7kp-1598
• Dissertation
• In Copyright - Educational Use Permitted
• Calhoun, Benjamin C
• Hoadley, Katherine A
• Troester, Melissa A
• Love, Michael I
• Williams, Scott E
• Doctor of Philosophy
• University of North Carolina at Chapel Hill Graduate School

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Master's Thesis on Mathematical Modeling of Prostate Cancer

The data will be used for model validation particular to Chapter 5 from the book mentioned on "Prostate Cancer: PSA, AR, and ADT Dynamics". Models include the Swanson, Vollmer and Humphrey, Jackson, and Ideta et al models in the textbook. We may also look at models provided in the references section at the end of the chapter.

M.A. student: Greyson Navarro, California State University San Bernardino.

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Wayne State University

School of medicine, cancer biology program cancer biology program, master of science in cancer biology, master of science  cancer biology graduate program department of oncology (updated 10-16-2023), program description, the master of science (ms) program in cancer biology offers a strong didactic and laboratory curriculum in cancer biology with a major focus on molecular oncology. our goal is to provide intensive research training for students who are interested in a career in academia, medicine, industry, or related careers in which first-hand research experience is an asset. research interests in the department of oncology are diverse, allowing students to choose from a broad spectrum of topics for their research thesis. students are encouraged to attend monthly research seminars, along with karmanos cancer institute-sponsored research meetings and symposia.  these regular interactions between students and faculty help our students develop oral communication and collaboration skills for future success., degree requirements, the master's degree in cancer biology is offered under plan a only. a minimum of 30 credits (eight of which must be from thesis research) and the completion of an original research project including a written master’s thesis are required to complete the requirements for the ms degree in cancer biology. the coursework includes 17 credits of compulsory courses and 5 credits of elective courses (below). a minimum gpa of 3.0 must be maintained throughout the ms program. students are required to complete two laboratory rotations by the second semester of year 1 of study in order to have a thesis advisor in place for beginning full time thesis research. the student and mentor should identify two additional faculty members to serve on the thesis committee. students should strive to publish one peer-reviewed paper in connection with the ms research., plan a curriculum (total 30 cr.), required courses (17 cr.):, mgg 7010 molecular biology & genetics (4 cr.) fall semester. bio 6000 molecular cell biology i (3 cr.) fall semester. cb 7210 fundamentals of cancer biology (3 cr.) winter semester. cb 7500 ms biostatistics (2 cr.) winter semester. cb 7510 - journal club/seminar ms, winter semester only (1 cr./ winter semester). total of 2 cr. over the course of the program. cb 7710 rotation (2 cr.) fall semester cb 7800 ethics (1 cr.) winter semester cb 8999 master’s thesis research (8 cr), elective courses (5 cr.): in addition to the courses listed above, students are allowed to select appropriate courses from other departments/programs across the campus., cb 7300 special topics (1-4 topics, 1 cr.) phc 7650 (1-4 topics, 1 cr.) psl 7880 special problems (1 cr.) admission requirements, admission to the ms program is contingent upon admission to the graduate school and the graduate programs of the  school of medicine . qualified applicants must have a bs or ba degree from an accredited college or university, preferably with a major in biology, chemistry, physics, or a closely related discipline. a complete application includes the basic application form, personal statement, official transcripts from previous institutions, and three letters of reference.  international students must be proficient in english (as determined by satisfactory performance on the test of english as a foreign language (toefl) examination). toefl scores should be reported to wayne state university using institution code 1898. applications must be submitted online by april 1 st . graduate school admissions policies can be found at the  office of graduate admissions., contact information, administrative office for ms program in cancer biology department of oncology wayne state university school of medicine 421 e canfield street detroit, mi 48201, tel: 313-578-4302 email: [email protected].

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Cancer Research (MS)

Print options, graduate committee .

Dr. Joyce Solheim (Chair & Program Director), Dr. Tadayoshi Bessho, Dr. Jennifer Black, Dr. Pi-Wan Cheng, Dr. Babu Guda, Dr. Keith Johnson, Dr. Xu Luo, Dr. Aaron Mohs, Dr. Youri Pavlov, Dr. Angie Rizzino, and Dr. Pankaj Singh

Scientists with Master of Science degrees can make many important contributions related to cancer, which is a very widespread and often deadly disease.  Students have the option of obtaining a Cancer Research MS degree after writing a research thesis (Thesis Option) or without a research thesis (Non-Thesis Option).  Graduates with the UNMC Cancer Research MS degree have taken positions in personalized medicine counseling, in management of research laboratories, and in directing community-based health projects.  

General Requirements

• Completion of at least 30 semester credits beyond the bachelor's degree, including both lecture coursework and research credits 
• Completion of coursework
•  Completion of the comprehensive examination
•  Completion of a research project consistent with a master's level achievement
•  Completion and successful defense of a master's thesis (Thesis Option only)

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Home > Dissertations, Master's Theses and Master's Reports > 1066

Dissertations, Master's Theses and Master's Reports

Off-campus Michigan Tech users: To download campus access theses or dissertations, please use the following button to log in with your Michigan Tech ID and password: log in to proxy server

Non-Michigan Tech users: Please talk to your librarian about requesting this thesis or dissertation through interlibrary loan.

A BAYESIAN CONVOLUTIONAL NEURAL NETWORK BASED CLASSIFIER TO DETECT BREAST CANCER FROM HISTOPATHOLOGICAL IMAGES AND UNCERTAINTY QUANTIFICATION

Pushkar Khairnar , Michigan Technological University Follow

Date of Award

Document type.

Campus Access Master's Thesis

Degree Name

Master of Science in Mechanical Engineering (MS)

Administrative Home Department

Department of Mechanical Engineering-Engineering Mechanics

Susanta Ghosh

Committee Member 1

Shiva Rudraraju

Committee Member 2

Benjamin W. Ong

Breast cancer is the most common cause of cancer in women. Histopathological imaging data can provide important information on cancer since it preserves the underlying tissue architecture in the preparation process. Accurate and automated classification of breast tissue into malignant or healthy from histological images can be used for the diagnosis of breast cancer. However, publicly available labeled histopathological datasets are limited in size and also biased. For such datasets, existing machine learning classifiers have shown limited success. The goal of the present work is to develop a classification technique using machine learning, which can overcome the challenge posed by small and biased datasets. This technique will reduce the inaccuracy of the image analysis, and quantify the uncertainty in their prediction.

The field of computer vision and neural networks are aimed at improving the accuracy of image analysis by various network architectures on algorithms. Plain feed-forward neural networks have been successfully used for pattern recognition, but their performance is good only when the data is sufficiently large. When the data size is limited, neural networks yield erroneous or overfitted results, since they don't take the uncertainty of the dataset into account. These feed-forward neural networks learn their weights as point estimates or a deterministic value. Whereas, a Bayesian neural network learns a probability distribution on the weights. The loss function used in Bayesian neural networks is known as a Variational Free Energy (VFE) or Evidence Lower Bound (ELBO) which is to be optimized. Since the Bayesian approach provides probability distributions on the weights of the neural networks, it is possible to calculate the variance of the predictive posterior probability distribution, which is the sum of aleatoric and the epistemic uncertainty. Uncertainty quantification, along with the point estimate, leads to a more informed decision, improved accuracy, and reduced overfitting. In critical applications, especially medical-imaging applications, uncertainty quantification can potentially reduce the unexpected and incorrect results due to the poor decisions. In this thesis, we have worked on the application of Bayesian neural networks on publicly available histopathological images for the detection of breast cancer and uncertainty quantification of the prediction. We have demonstrated that using the Bayesian CNN, the false-negative predictions can be reduced remarkably, by almost 22%. We have found that the predictions associated with higher epistemic uncertainties have features of both the classes. These findings should improve the state of the art machine learning-based biomedical imaging.

Recommended Citation

Khairnar, Pushkar, "A BAYESIAN CONVOLUTIONAL NEURAL NETWORK BASED CLASSIFIER TO DETECT BREAST CANCER FROM HISTOPATHOLOGICAL IMAGES AND UNCERTAINTY QUANTIFICATION", Campus Access Master's Thesis, Michigan Technological University, 2020.

https://doi.org/10.37099/mtu.dc.etdr/1066

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MS in Cancer Research

Search for solutions to one of medicine's greatest challenges with an innovative Cancer Research MS from UNMC.

Why Study Cancer Research?

Advancement in the detection and treatment of cancer continues to accelerate through ground-breaking research, yet cancer remains one of the most complex and challenging problems of biomedical research.

As a cancer researcher, you'll work to better understand the causes of cancer, improve the methods for diagnosis and improve treatment and prevention methods. The answers you find may save a life you know — or your own.

We're in an exciting new dawn in biomedical science where we will see many cures previously deemed impossible.

Why Study Cancer Research at UNMC?

Cancer research is a key area of research at UNMC. Researchers at UNMC are engaged in work that addresses the root causes of cancer, as well as the means of enhancing the detection and treatment. This research employs a wide range of animal and cellular model systems, includes both basic and translational research, and focuses heavily on the molecular basis of cancer. As a result, you'll receive broad-based training in all aspects of cancer biology and employ cutting-edge experimental approaches.

Our innovative program trains future scientists to approach cancer research knowledgeably and creatively and to enter careers in which they can make a significant contribution.

Program Snapshot

Financial benefits.

All Cancer Research MS students receive a stipend of $15,750 (this will be raised to $16,500 on July 1, 2024) and a tuition waiver. Additionally, UNMC students fees and health insurance are paid for the student.

Careers & Outcomes

Graduates with the UNMC Cancer Research MS degree have taken positions in personalized medicine counseling, in management of research laboratories, and in directing community-based health projects. Graduates have gone on to careers such as bench scientist with an international pharmaceutical company, research associate at a research technology company, and as manager in research laboratory.

Sample careers include:

• Senior Licensing Specialist (a position that involves working out agreements between academic laboratories and pharmaceutical industries to commercialize new cancer-related discoveries)
• Assistant Director of a Clinical Molecular Oncology Laboratory
• Director of Bioengineering for a global biopharmaceutical company
• Scientific Director at a company specializing in health-related media communications
• Clinical Instructor

The Eppley Institute for Research in Cancer and Allied Diseases

The Eppley Institute is fighting cancer with some of the brightest minds in science. Faculty and students have access to state-of-the-art research equipment both within the Eppley Institute and in other shared on-campus facilities.

Related Programs

Students interested in this program may wish to explore:

2024-25 Academic Catalog

Master of science in cancer biology.

The Master of Science (M.S.) program in Cancer Biology prepares the student for a career at the advanced technical level in academia, industry, or government. Graduating students may also find teaching positions at the secondary or junior college level. 

The application process is an online process. Application to this graduate program is facilitated through the Interdisciplinary Graduate Program in Biomedical Sciences (IGPBS). Detailed instructions on how to apply and the application deadlines are posted on the Interdisciplinary Graduate Program in Biomedical Sciences website http://www.kumc.edu/igpbs/how-to-apply.html .

Admission Requirements:

• Bachelor’s degree from a regionally accredited institution documented by submission of official transcript indicating the degree has been conferred before entering the program. Official transcripts from institutions attended post-baccalaureate are also required. Students with degrees from outside the U.S. may be subject to transcript evaluation indicating the degree is equivalent to a U.S. degree and meets the minimum cumulative GPA requirements.
• A cumulative grade-point average (GPA) of at least a 3.0 on a 4.0 scale for the bachelor’s degree.
• Applicants who are not native speakers of English, whether domestic or international, must demonstrate they meet the Minimum English Proficiency Requirement .
• A background check is required during the admission process; it may affect the student's eligibility to enter the program.
• Three letters of recommendation.
• One year of general chemistry
• One year of organic chemistry or one semester of organic chemistry and one semester of biochemistry
• One year of biological sciences
• One semester of calculus
• One semester of physics
• Research experience (beyond labs associated with lecture courses) is strongly suggested.

Applicants will be assessed based on a combination of GPA, and research experience. Students not meeting the above requirements may be eligible for provisional admission.  After an applicant has been admitted, a program may defer an applicant's admission for one year after which time the applicant must submit a new application.

Admission requirements are subject to change. In most cases, use the catalog of the year student entered the program. Other years’ catalogs ».

The Master of Science (M.S.) program in Cancer Biology prepares the student for a career at the advanced technical level in academia, industry, or government.

Degree requirements:

• Degree requirements are normally completed within 3 years of admission to the program although a maximum of 7 years is allowed.
• Completion of a minimum of 30 credit hours.
• Cumulative grade-point average (GPA) of at least a 3.0 for all KU graduate coursework.
• Enrollment in a minimum of one (1) credit hour of  CBIO 899 Master's Thesis in Cancer Biology the semester the student will defend the thesis and graduate.
• Successful completion of the thesis defense  or general examination the semester the student will graduate. The thesis should be comparable in scope to justify co-authorship on a rigorously peer-reviewed manuscript.  In general, CBIO students graduating with an MS degree should have justified co-authorship on at least one peer-reviewed publication (as determined by their thesis advisory committee).
• Successful Thesis Submission and Publication (according to Office of Graduate Studies policy.)
• Successful completion of  PATH 913 Introduction to Grant Proposal Writing .
• Continued attendance at the KUCC seminar (minimum 75% required determined by sign-in) in both the Fall and Spring semesters after completing 5 semesters of CBIO 850 Cancer Center Seminar .
• Annual presentation and continued attendance at Communicating Cancer Science in both the Fall and Spring semesters after completing 5 semesters of CBIO 860 Communicating Cancer Science .
• Annual participation and/or attendance at the KU Medical Center Student Research Forum.
• Annual participation and/or attendance at the KU Cancer Center Research Retreats.

Degree requirements and course descriptions are subject to change. Any courses taken as an equivalent must be approved by the Graduate Director and the Office of Graduate Studies. In most cases, use the catalog of the year student entered the program.    Other years’ catalogs ».

Typical Plan of Study

TECHNICAL STANDARDS AND REQUIREMENTS FOR THE M.S. IN CANCER BIOLOGY

The M.S. degree signifies that the holder is prepared for entry into research in industrial or academic laboratory settings. To that end, graduates must have the knowledge and skills to function in a broad variety of laboratory settings.

• Observation: The candidate must be able to observe demonstrations and experiences in the basic sciences, including but not limited to biology demonstrations in animals, cultures, and microscopic studies of tissues in normal and pathologic states. A candidate must be able to observe and analyze experimental detail. Observation necessitates the functional use of the sense of vision and somatic sensation.
• Communication: A candidate should be able to communicate, to understand, and to observe lectures and laboratory instruction. A candidate must be able to communicate effectively in order to present and analyze research data. Communication includes not only speech, but also reading and writing. The candidate must be able to communicate effectively and efficiently in oral and written form with students, staff, and faculty.
• Motor: Candidates should have sufficient motor function to carry out lab techniques. A candidate should be physically able to do laboratory procedures and analyze data. Such actions require coordination of both gross and fine muscular movements, equilibrium, and functional use of the senses of touch and vision.
• Intellectual-Conceptual, Integrative, and Quantitative Abilities: The abilities include measurement, calculation, reasoning, analysis, and synthesis. Problem solving, the critical skill demanded of scientists, requires all of these intellectual abilities. In addition, the candidate should be able to comprehend three-dimensional relationships and to understand the spatial relationships of structures.
• Behavioral and Social Attributes: A candidate must possess the emotional health required for full utilization of his/her intellectual abilities, the exercise of good judgment and the prompt completion of all responsibilities attendant to the completion of research and teaching responsibilities. Integrity and motivation are personal qualities, which are required for success in science.

Disabled individuals are encouraged to apply. Applicants whose response indicates that they cannot meet the expectations will be reviewed by the Graduate Committee and Technical Support staff of KUMC to assess the extent of the student’s difficulties. At this review the provisions for reasonable accommodation will be determined.

For further information, contact the Department of Cancer Biology, University of Kansas School of Medicine, 2003 Wahl Hall West, 3901 Rainbow Blvd., Kansas City, Kansas 66160 (Phone: (913) 945-7739 E-mail: [email protected]

STUDENT POLICY ON INFECTIOUS DISEASE

Due to the need to assure the health and safety of students, faculty, and staff, the fact that an applicant for admission has an infectious disease or is the carrier of an infectious disease may be a factor in determining eligibility for academic program admission at the University of Kansas Medical Center. Determination of eligibility for admission in such cases will be made on an individual basis in consultation with the applicant’s physician, taking into consideration (among other factors), legal requirements and the current best medical information available to determine whether the applicant could complete the normal course of study with reasonable accommodation and without risk to him/herself or to others. Therefore, applicants having an infectious disease or who are carriers of an infectious disease must advise the Graduate Committee of this fact and may be required to provide medical records for review by the Student Health Physician in order to determine eligibility for admission.

DRUG FREE WORKPLACE POLICY OF THE UNIVERSITY OF KANSAS

It is the policy of the University of Kansas that unlawful manufacture, distribution, dispensing, possession, or use of controlled substances or alcohol is prohibited in buildings, facilities, or grounds controlled by the University. Any student found to be illegally manufacturing, distributing, dispensing, possessing, or using controlled substances or alcohol at the University or any of its affiliated educational sites, shall be subject to disciplinary action in accordance with applicable policies as outlined in the Graduate Student Handbook . Students are reminded that illegal manufacture, distribution, dispensing, possession, or use of controlled substances may also subject individuals to criminal prosecution.

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